TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor Kappa B activation in a rat model of hepatocellular carcinoma

Free Radical Research

Volumn 37, Issue 8, 2003, Pages 841-848

  Mauriz, Jose L ^a   Linares, Pedro ^b   Macias, Rocio I R ^c   Jorquera, Francisco ^b   Honrado, E ^b   Olcoz, Jose L ^b   González, Paquita ^a   González Gallego, Javier ^a  

^a UNIVERSITY OF LEÓN   (Spain)

^b Hospital of Leon   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Cancer; Glutathione; NF B; Nitric oxide; Oxidative stress; TNP 470

Indexed keywords

ANGIOGENESIS INHIBITOR; DIETHYLNITROSAMINE; FUMAGILLOL CHLOROACETYLCARBAMATE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N (2 FLUORENYL)ACETAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; CONTROLLED STUDY; DRUG MECHANISM; DYSPLASIA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER LEVEL; LIVER RESECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REVIEW; TUMOR GROWTH;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; BODY WEIGHT; CARCINOMA, HEPATOCELLULAR; CYCLOHEXANES; DIETHYLNITROSAMINE; ENZYME ACTIVATION; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; HUMANS; I-KAPPA B PROTEINS; LIVER; LIVER NEOPLASMS; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RATS; RATS, WISTAR; SESQUITERPENES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS; VON WILLEBRAND FACTOR;

ANIMALIA;

EID: 0041632369     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/1071576031000136577     Document Type: Review

References (46)

1. Liekens, S., De Clercq, E. and Neyts, J. (2001) "Angiogenesis: regulators and clinical applications", Biochem. Pharmacol. 61, 253-270.
2. Yoshida, A., Anand-Apte, B. and Zetter, B.R. (1996) "Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor", Growth Factors 13, 57-64.
3. Sasaki, A., Alcalde, R.E., Nishiyama, A., Lim, D.D., Mese, H., Akedo, H. and Matsumura, T. (1998) "Angiogenesis inhibitor TNP-470 inhibits human breast cancer osteolytic bone metastasis in nude mice through the reduction of bone resorption", Cancer Res. 58, 462-467.
4. Liekens, S., Verbeken, E., Vandeputte, M., De Clercq, E. and Neyts, J. (1999) "A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470", Cancer Res. 59, 2376-2383.
5. Turk, B.E., Griffith, E.C., Wolf, S., Biemann, K., Chang, Y.H. and Liu, J.Q. (1999) "Selective inhibition of amino-terminal methionine processing by TNP-470 and ovacilin in endothelial. cells", Chem. Biol. 6, 823-833.
6. Morales, C., Zurita, M. and Vaquero, J. (2002) "Antitumor effect of TNP-470 is not associated to decrease of angiogenesis in an experimental malign at neuroectodermic tumor", J. Neurooncol. 58, 131-136.
7. Gervaz, P., Scholl, B., Padrum, V. and Gillet, M. (2000) "Growth inhibition of liver metastases by the anti-angiogenic drug TNP-470", Liver 20, 108-113.
8. Toyokuni, S., Okamoto, K., Yodoi, J. and Hiai, H. (1995) "Persistent oxidative stress in cancer", FEBS Lett. 358, 1 -3.
9. Fiander, H. and Schneider, H. (2000) "Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and detoxification of mutagenic xenobiotics", Cancer Lett. 156, 117-124.
10. Hensley, K., Robinson, K.A., Gabbita, S.P., Salsman, S. and Floyd, R.A. (2000) "Reactive oxygen species, cell signalling, and cell injury", Free Radic. Biol. Med. 28, 1456-1462.
11. Van den Berg, R., Haenen, G.R., Van den Berg, H. and Bast, A. (2001) "Transcription factor NF-κB as a potential biomarker for oxidative stress", Br. J. Nutr. 86, S121-S127.
12. Shibata, A., Nagaya, T., Imai, R., Funahashi, H., Nakao, A. and Seo, H. (2002) "Inhibition of NF-kappaB activity decreases the VEGF mRNA expression in MDA-MB-231 breast cancer cells", Breast Cancer Res. Treat. 73, 237-243.
13. Liu, P., Kimmoun, E., Legrand, A., Sauvanet, A., Degott, C., Lardeux, B. and Bernuau, D. (2002) "Activation of NF-kappaB, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas", J. Hepatol. 37, 63-71.
14. Hur, G.M., Ryu, Y.S., Yun, H.Y., Jeon, B.H., Kim, Y.M., Seok, J.H. and Lee, J.H. (1999) "Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-κB", Biochem. Biophys. Res. Commun. 261, 917-922.
15. Ziche, M. and Morbidelli, L. (2000) "Nitric oxide and angiogenesis", J. Neurooncol. 50, 139-148.
16. Liaudet, L., García-Soriano, F. and Szabo, C. (2000) "Biology of nitric oxide signalling", Crit. Care Med. 28, N37-N52.
17. Acker, T. and Plate, K.H. (2002) "A role for hypoxia-inducible transcription factors in tumor physiology", J. Mol. Med. 80, 562-575.
18. Solt, D. and Farber, E. (1976) "New principle for the analysis of chemical carcinogenesis", Nature 263, 701-703.
19. Higgins, G.F. and Anderson, R.M. (1931) "Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal", Arch. Pathol. 12, 186-202.
20. Hissin, P.J. and Hilf, R.A. (1976) "Fluorimetric method for determination of oxidised and reduced glutathione in tissues", Anal. Biochem. 74, 214-226.
21. Ohkawa, H., Ohishi, N. and Yagi, K. (1979) "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction", Anal. Biochem. 95, 351-358.
22. Monte, M.J., Palomero, M., Sainz, G.R., Domínguez, M., Díez, M., Toraño, A. and Marin, J.J.G. (2000) "Bile acid secretion during rat liver carcinogenesis", Life Sci. 66, 1085-1095.
23. Essani, N.A., McGuire, G.M., Manning, A.M. and Jaeschke, H. (1996) "Endotoxin-induced activation of the nuclear transcription factor NF-κB in hepatocytes, Kupffer cells and endothelial cells in vivo", J. Immunol. 156, 2956.
24. Monte, M.J., Dominguez, S., Palomero, M.F., Macias, R.I. and Marin, J.J.G. (1999) "Further evidence of the uselfulness of bile acids as molecules for shuttling cytostatic drugs toward liver tumors", J. Hepatol. 31, 521-528.
25. Sato, K. (1989) "Glutathione trasnferases as markers of preneoplasia and neoplasia", Adv. Cancer Res. 52, 205-255.
26. Imai, T., Masui, T., Ichinose, M., Nakanishi, H., Yanai, T., Masegi, T., Muramatsu, M. and Tatematsu, M. (1997) "Reduction of glutathione S-transferase P-form mRNA expression in remodelling nodules in rat liver revealed by in situ hybridisation", Carcinogenesis 18, 545-551.
27. Tsuzuki, S., Yamauchi, A., Nakamura, H., Kinoshita, K., Gomi, T., Tanaka, K., Inamoto, T. and Yamaoka, Y. (1998) "Possible availability of N-cetylcysteine as an adjunct to cytokine therapy for hepatocellular carcinoma", Clin. Immunol. Immunopathol. 88, 192-198.
28. Navarro, J., Obrador, E., Carretero, J., Petschen, I., Aviño, J., Perez, P. and Estrela, J.M. (1999) "Changes in glutathione status and the antioxidant system in blood and in cancer cells associated with tumour growth in vivo", Free Radic. Biol. Med. 26, 410-418.
29. Huang, Z.Z., Chen, C., Zeng, Z., Yang, H., Oh, J., Chen, L. and Lu, S.C. (2001) "Mechanisms and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration", FASEB J. 15, 19-21.
30. Terradez, P., Asensi, M., Lasso de la Vega, M.C., Puertes, I.R., Viña, J. and Estrela, J.M. (1993) "Depletion of tumour glutathione in vivo by buthionine sulfoximine: modulation by the rate of cellular proliferation and inhibition of cancer growth Biochem. J. 292, 477-483.
31. Son, H.J., Kim, Y.H., Park, D.I., Kim, J.J., Rhee, P.L., Paik, S.W., Choi, K.W., Song, S.Y. and Rhee, J.C. (2001) "Interaction between cyclooxygenase-2 and inducible nitric oxide syntahse in gastric cancer", J. Clin. Gastroenterol. 33, 383-388.
32. Doi, K., Akaike, T., Horie, H., Noguchi, Y., Fujii, S., Beppu, T., Ogawa, M. and Maeda, H. (1996) "Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth", Cancer 77, 1598-1604.
33. Maeda, H. and Akaike, T. (1998) "Nitric oxide and oxygen radical in infection, inflammation and cancer", Biochemistry 63, 854-856.
34. Liu, T.Z., Hu, C.C., Andrew, C., Chen, Y., Stern, A. and Cheng, J.T. (2000) "Differentiation status modulates transcription factor NF-κB activity in unstimulated human hepatocellular carcinoma cell lines", Cancer Lett. 151, 49-56.
35. Locigno, R., Antoine, N., Bours, V., Daukandt, M., Heinen, E. fand Castronovo, V. (2000) "TNP-470, a potent angiogenesis inhibitor, amplifies human lymphocyte activation through an induction of nuclear factor-κB, nuclear factor AT, and activation protrein-1 transcription factor", Lab. Investig. 80, 13-21.
36. Dhar, A., Young, M.R. and Colburn, N.H. (2002) "The role of AP-1, NF-kappa B and ROS/NOS in skin carcinogenesis: the JB6 model is predictive", Mol. Cell. Biochem., 234-235, 185-193.
37. Kin, M., Torimura, T., Ueno, T., Nakamura, T., Ogata, R., Sakamoto, M., Tamaki, S. and Sata, M. (2000) "Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats", Int. J. Oncol. 16, 375-382.
38. Irving, M.G., Roll, F.J., Huang, S. and Bissell, D.M. (1984) "Characterization and culture of sinusoidal endothelium form normal rat liver: lipoprotein uptake and collagen phenotype", Gastroenterology 87, 1233-1247.
39. Kin, M., Torimura, T., Ueno, T., Inuzuka, S. and Tanikawa, K. (1994) "Sinusoidal capillarization in small hepatocellular carcinoma", Pathol. Int. 44, 771-778.
40. Takami, S., Ueno, T., Torimura, T., Sata, M. and Tanikawa, K. (1996) "Evaluation of hyaluronic acid binding ability of hepatic sinusoidal endotelial cells in rats with liver cirrosis", Gastroenterology 114, 1049-1057.
41. Folkman, J. (2001) "Angiogenesis-dependent diseases", Semin. Oncol. 28, 536-542.
42. Folkman, J., Browder, T. and Palmblad, J. (2001) "Angiogenesis research: guidelines for translation to clinical application", Thromb. Haemost. 86, 23-33.
43. Wang, Y.Q., Ikeda, K., Ikebe, T., Hirakawa, K., Sowa, M., Nakatani, K., Kawada, N. and Kaneda, K. (2000) "Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats", Hepatology 32, 980-989.
44. Castronovo, V. and Belotti, D. (1996) "TNP-470. Mechanisms of action and early clinical development", Eur. J. Cancer 32A, 2520-2527.
45. Ahmed, M.H., Konno, H., Nahar, L., Tanaka, T., Naito, Y., Nakamura, S. and Baba, S. (1996) "The angiogenesis inhibitor TNP-470 (AGM-1470) imrpoves long-term survival of rats with liver metastases", J. Surg. Res. 64, 35-41.
46. Smyth, J.F., Bowman, A., Perren, T., Wilkinson, P., Prescott, R.J., Quim, K.J. and Tedeschi, K.M. (1997) "Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplastin: results of a double-blind, randomised trial", Ann. Oncol. 8, 569-573.