Electrophysiological evidence for glial-subtype glutamate transporter functional expression in rat cerebellar granule neurons

Brazilian Journal of Medical and Biological Research

Volumn 36, Issue 7, 2003, Pages 951-957

  Mafra, R A ^a,b   Leao R M ^a,c   Beirao P S L ^a   Cruz, J S ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cerebellar granule neurons; Excitatory amino acid transporter type 2; Glutamate; Patch clamp; Whole cell voltage clamp

Indexed keywords

DIHYDROKAINIC ACID; GLUTAMATE TRANSPORTER; GLUTAMIC ACID;

ANIMAL CELL; ARTICLE; CEREBELLUM; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLIA; GRANULE CELL; INHIBITION KINETICS; MALE; MEMBRANE ELECTROPHYSIOLOGY; NERVE CELL; NERVE CELL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PATCH CLAMP; PROTEIN EXPRESSION; RAT; STEADY STATE; TRANSPORT KINETICS;

ANIMALIA;

EID: 0041590986     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2003000700018     Document Type: Article

References (31)

1. Diamond JS & Jahr CE (2000). Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation. Journal of Neurophysiology, 83: 2835-2843.
2. Tong G & Jahr CE (19b4). Block of glutamate transporters potentiates postsynaptic excitation. Neuron, 13: 1195-1203.
3. Voght KE & Nicoll RA (1999). Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. Proceedings of the National Academy of Sciences, USA, 96: 1118-1122.
4. Mitchell SJ & Silver RA (2000). Glutamate spillover suppresses inhibition by activating presynaptic mGluRs. Nature, 404: 498-502.
5. Lin CL, Bristol LA, Jin L, Dykes-Hoberg M, Crawford T, Clawson L & Rothstein JD (1998). Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter in amyotrophic lateral sclerosis. Neuron, 20: 589-602.
6. Tanaka K, Watase K, Manabe T et al. (1997). Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science, 276: 1699-1702.
7. Rothstein JD, Dykes-Hoberg M, Pardo CA et al. (1996). Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron, 16: 675-686.
8. Danbolt NC (2001). Glutamate uptake. Progress in Neurobiology, 65: 1-105.
9. Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N & Kunkl R (1994). Localization of neuronal and glial glutamate transporters. Neuron, 13: 713-725.
10. Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J & Danbolt NC (1995). Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. Journal of Neuroscience, 15: 1835-1853.
11. Peghini P, Janzen J & Stoffel W (1997). Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO Journal, 16: 3822-3832.
12. Jakab RL & Hamori J (11988). Quantitative morphology and synaptology of cerebellar glomeruli in the rat. Anatomy and Embryology, 179: 81-88.
13. Wall MJ & Usowicz MM (1998). Development of the quantal properties of evoked and spontaneous synaptic currents at a brain synapse. Nature Neuroscience, 1: 675-682.
14. Rossi DJ & Hamann M (1998). Spillover-mediated transmission at inhibitory synapses promoted by high affinity alpha6 subunit GABA(A) receptors and glomerular geometry. Neuron, 20: 783-795.
15. Leão RM, Mellor JR & Randall AD (2000). Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells. Neuropharmacology, 39: 990-1003.
16. Sarantis M, Ballerini L, Miller B, Silver RA, Edwards M & Attwell D (1993). Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current. Neuron, 11: 541-549.
17. Takahashi M, Sarantis M & Attwell D (1998). Glutamate uptake in Purkinje cells in rat cerebellar slices. Methods in Enzymology, 296: 608-617.
18. Otis TS, Wu Y-C & Trussell LO (1996). Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites. Journal of Neuroscience, 16: 1634-1644.
19. Overstreet LS, Kinney GA, Liu YB, Billups D & Slater NT (1999). Glutamate transporters contribute to the time course of synaptic transmission in cerebellar granule cells. Journal of Neuroscience, 19: 9663-9673.
20. Mennerick S & Zorumski CF (1994). Glial contributions to excitatory neurotransmission in cultured hippocampal cells. Nature, 368: 59-62.
21. McIllvain HB, Lou Z & Dunlop J (1999). Expression of excitatory amino-acid transporters in rat cerebellar granule neuron cultures. Society for Neuroscience Abstracts, 25: 171 (Abstract 15).
22. Hamill OP, Marty A, Neher E, Sakmann B & Sigworth FJ (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv. European Journal of Physiology, 391: 85-100.
23. Wadiche JI, Arriza JL, Amara SG & Kavanaugh MP (1995). Kinetics of a human glutamate transporter. Neuron, 14: 1019-1027.
24. Eliasof S, Arriza JL, Leighton BH, Kavanaugh MP & Amara SG (1998). Excitatory amino acid transporters of the salamander retina: identification, localization, and function. Journal of Neuroscience, 18: 698-712.
25. Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP & Amara SG (1994). Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. Journal of Neuroscience, 14: 5559-5569.
26. Pines G, Danbolt NC, Bjoras M, Zhang Y, Bendahan A, Eide L, Koepsell H, Seeberg E, Storm-Mathisen J & Kanner BI (1992). Cloning and expression of a rat brain L-glutamate transporter. Nature, 360: 464-467.
27. Furuta A, Martin LJ, Lin CL, Dykes-Hoberg M & Rothstein JD (1997). Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4. Neuroscience, 81: 1031-1042.
28. Billups B & Attwell D (1996). Modulation of non-vesicular glutamate release by pH. Nature, 379: 171-174.
29. Zerangue N & Kavanaugh MP (1996). Flux coupling in a neuronal glutamate transporter. Nature, 383: 634-637.
30. Eliasof S, Arriza JL, Leighton BH, Amara SG & Kavanaugh MP (1998). Localization and function of five glutamate transporters cloned from the salamander retina. Vision Research, 38: 1443-1454.
31. Wang GJ, Chung HJ, Schnuer J, Pratt K, Zable AC, Kavanaugh MP & Rosenberg PA (1998). High affinity glutamate transport in rat cortical neurons in culture. Molecular Pharmacology, 53: 88-96,