Design and novel synthesis of aryl-heteroaryl-imidazole MAP kinase inhibitors

Tetrahedron Letters

Volumn 44, Issue 38, 2003, Pages 7115-7117

  Dobler, Markus R ^a  

^a SYNGENTA CROP PROTECTION AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN;

ANTIFUNGAL ACTIVITY; ARTICLE; BIODIVERSITY; DRUG DESIGN; DRUG EFFECT; DRUG SYNTHESIS; INFLAMMATION; RHEUMATOID ARTHRITIS;

EID: 0041508525     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01834-3     Document Type: Article

References (19)

1. Brennan F.M., Feldmann M. Curr. Opin. Immunol. 8:1996;872-877.
2. Camussi G., Lupia E. Drugs. 55:1998;613-620.
3. Gallagher T.F., Seibel G.L., Kassis S., Laydon J.T., Blumenthal M.J., Lee J.C., Lee D., Boehm J.C., Fier-Thompson S.M., Abt J.W., Soreson M.E., Smietana J.M., Hall R.F., Garigipati R.S., Bender P.E., Erhard K.F., Krog A.J., Hofmann G.A., Sheldrake P.L., McDonnell P.C., Kumar S., Young P.R., Adams J.L. Bioorg. Med. Chem. 5:1997;49-64.
4. Badger A.M., Bradbeer J.N., Votta B., Lee J.C., Adams J.L., Griswold D.E. J. Pharmacol. Exp. Ther. 279:1996;1453-1461.
5. (a) Pillonel C., Meyer T. Pestic. Sci. 49:1997;229-236;
6. Mitani, A.; Ichinari, D.; Saiga, M.; Hamamura, H.; Sugiura, T. Jpn. Kokai Tokkyo Koho, 2000, JP, JP 2000273088 A2, 28 pp.
7. For examples, see: (a) Gordon, T. D.; Singh, J.; Hansen, P. E.; Morgan, B. A. Tetrahedron Lett. 1993, 34, 1901-1904; (b) Bilodeau, M. T.; Cunnigham, A. M. J. Org. Chem. 1998, 63, 2800-2801; (c) Jetter, M. C.; Reitz, A. B. Synthesis 1998, 829-831; (d) Njar, V. C. O. Synthesis 2000, 2019-2028; (e); Bleicher, K. H.; Gerber, F.; Wuthrich, Y.; Alanine, A.; Capretta, A. Tetrahedron Lett. 2002, 43, 7687-7690.
8. For examples, see: (a) Gordon, T. D.; Singh, J.; Hansen, P. E.; Morgan, B. A. Tetrahedron Lett. 1993, 34, 1901-1904; (b) Bilodeau, M. T.; Cunnigham, A. M. J. Org. Chem. 1998, 63, 2800-2801; (c) Jetter, M. C.; Reitz, A. B. Synthesis 1998, 829-831; (d) Njar, V. C. O. Synthesis 2000, 2019-2028; (e); Bleicher, K. H.; Gerber, F.; Wuthrich, Y.; Alanine, A.; Capretta, A. Tetrahedron Lett. 2002, 43, 7687-7690.
9. For examples, see: (a) Gordon, T. D.; Singh, J.; Hansen, P. E.; Morgan, B. A. Tetrahedron Lett. 1993, 34, 1901-1904; (b) Bilodeau, M. T.; Cunnigham, A. M. J. Org. Chem. 1998, 63, 2800-2801; (c) Jetter, M. C.; Reitz, A. B. Synthesis 1998, 829-831; (d) Njar, V. C. O. Synthesis 2000, 2019-2028; (e); Bleicher, K. H.; Gerber, F.; Wuthrich, Y.; Alanine, A.; Capretta, A. Tetrahedron Lett. 2002, 43, 7687-7690.
10. For examples, see: (a) Gordon, T. D.; Singh, J.; Hansen, P. E.; Morgan, B. A. Tetrahedron Lett. 1993, 34, 1901-1904; (b) Bilodeau, M. T.; Cunnigham, A. M. J. Org. Chem. 1998, 63, 2800-2801; (c) Jetter, M. C.; Reitz, A. B. Synthesis 1998, 829-831; (d) Njar, V. C. O. Synthesis 2000, 2019-2028; (e); Bleicher, K. H.; Gerber, F.; Wuthrich, Y.; Alanine, A.; Capretta, A. Tetrahedron Lett. 2002, 43, 7687-7690.
11. For examples, see: (a) Gordon, T. D.; Singh, J.; Hansen, P. E.; Morgan, B. A. Tetrahedron Lett. 1993, 34, 1901-1904; (b) Bilodeau, M. T.; Cunnigham, A. M. J. Org. Chem. 1998, 63, 2800-2801; (c) Jetter, M. C.; Reitz, A. B. Synthesis 1998, 829-831; (d) Njar, V. C. O. Synthesis 2000, 2019-2028; (e); Bleicher, K. H.; Gerber, F.; Wuthrich, Y.; Alanine, A.; Capretta, A. Tetrahedron Lett. 2002, 43, 7687-7690.
12. Carver D.S., Lindell S.D., Saville-Stones E.A. Tetrahedron. 53:1997;14481-14496.
13. Benhida R., Lezama R., Fourrey J.-L. Tetrahedron Lett. 39:1998;5963-5964.
14. Groziak, M. P.; Wei, L. J. Org. Chem. 1991, 56, 4296-4300, ibid. 1992, 57, 3776-3780.
15. Takeuchi Y., Kirk K.L., Cohen L.A. J. Org. Chem. 43:1978;3570-3580.
16. Takeuchi Y., Yeh H.J.C., Kirk K.L., Cohen L.A. J. Org. Chem. 43:1978;3565-3570.
17. Rottlander M., Boymond L., Berillon L., Lepretre A., Varchi G., Avolio S., Laaziri H., Queguiner G., Ricci A., Cahiez G., Knochel P. Chem. Eur. J. 6:2000;767-770.
18. Bell A.S., Roberts D.A., Ruddock K.S. Tetrahedron Lett. 29:1988;5013-5016.
19. +1).