Inhibition of γ-radiation induced DNA damage in plasmid pBR322 by TMG, a water-soluble derivative of vitamin E

Journal of Radiation Research

Volumn 43, Issue 2, 2002, Pages 153-159

  Rajagopalan, Rema ^a   Wani, Khalida ^b   Huilgol, Nagaraj G ^b   Kagiya, Tsutomu V ^c   Nair, Cherupally K Krishnan ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

^b Nanavati Hospital and MRC   (India)

^c Kinki Research Foundation   (Japan)

Author keywords

DNA strandbreaks; Radiation protection; Thymine glycol; Tocopherol Monoglucoside

Indexed keywords

BIOMOLECULES; GAMMA RAYS; GLYCOLS; RADIATION PROTECTION;

DNA DAMAGES; DNA STRANDBREAK; PLASMID PBR322; RADIATION-INDUCED; SINGLE-STRAND BREAKS; THYMINE GLYCOL; TOCOPHEROL MONOGLUCOSIDE; VITAMIN-E; WATER-SOLUBLE DERIVATIVES; Γ-RADIATION;

DNA;

2 (GLUCOPYRANOSYL)METHYL 2,5,7,8 TETRAMETHYLCHROMAN 6 OL; 2-(GLUCOPYRANOSYL)METHYL-2,5,7,8-TETRAMETHYLCHROMAN-6-OL; ALPHA TOCOPHEROL; CHROMAN DERIVATIVE; DNA; DRUG DERIVATIVE; GLYCOSIDE;

ARTICLE; DNA DAMAGE; GAMMA RADIATION; GENETICS; PLASMID; RADIATION EXPOSURE;

CHROMANS; DNA; DNA DAMAGE; GAMMA RAYS; GLYCOSIDES; PLASMIDS; VITAMIN E;

EID: 0039490007     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.43.153     Document Type: Article

References (35)

1. Scholes, G. (1982).Radiation effects on DNA,: The Silvanus Thomson memorial lecture,The Silvanus Thomson memmorial lecture, Brit. J. Radiol. 56: 221-231.
2. Von Sonntag, C. (1987). The Chemical Basis of Radiation Biology, Taylor and Francis, London
3. Pradhan, D. S., Nair, C. K. K.and Sreenivasan, A. (1972) Radiation injury and sensitization of microorganisms, Proc. Ind. Natl. Sci. Acad., 39B: 516-530
4. Tomota, H., Kai, M., Kusama, T., and Ito, I., (1997). Monte Carlo simulation of physicochemical process of liquid water radiolysis, Radiat. Environ. Biophysics. 36: 105-116
5. Alper, T. (1979) Cellular Radiobiology, Cambridge University press, Cambridge.
6. Choudhary, D., Chandra, D. and. Kale, R. K. (1999). Modulation of radio-response of glyoxalase system by curcumin., J. Ethanopharmacol. 64: 1-7.
7. Nair, C. K. K., Parida, D. K., and Nomura, T., (2001). Radioprotectors in Radiotherapy, J Radiat. Res. 42, 21-37
8. Wilson,. R. L (1983) Free radical repair mechanisms and the interaction of glutathione and vitamin C and E, In Radioprotectors and anticarcinogens, eds, O. F. Nyga and M. G. Simic, pp 1-23, Academic press, Newyork.
9. Umadevi, P., Ganasoundari, A.,. Rao B. S. S and Srinivasan, K. K., (1999). In vivo radioprotection by ocimum flavanoids: survival of mice. Radiat. Res. 151, 74-78
10. Santhosh Kumar, S. Chaubey, R. C., Devasagayam, T. P.A., Priyadarshini, K. I. and. Chauhan, P. S. (1999) Inibition of radiation-induced DNA damage in plasmid pBR322 by chlorophyllin and possible mechanism(s) of action, Mutation Res. 425: 71-79.
11. Murase, H., Yamaguchi, R., Kato, K., Kunieda, T. and. Terao, J (1997) Synthesis of a novel vitamin derivative, 2-(α-D glucopyranosyl) methyl-2,5,7,8-tetramethyl chroman-6-ol by a-glucosidase-catalysed transglycosylation, Lipids, 32: 73-78.
12. Shimanskaya, R., Kagiya, T. and Murase, H. (2001) Radioprotective effect of water-soluble vit.E analogue (TMG), ISRH 2001 Satellite Symposium, Radioprotectors for Human Health, July 16, 2001. Kyoto, Japan, Abstract book, p12.
13. Gu, Y. H., Hasegawa, T., Murase, H. and Kagiya, T. (2001) Radioprotective effect of water-soluble vitamin E (TMG) on the organogenesis stage of embryos in ICR mice, ISRH 2001 Satellite Symposium, Radioprotectors for Human Health, July 16, 2001. Kyoto, Japan, Abstract Book, p23.
14. Satyamitra, M., Umadevi, P., Murase, H and Kagiya, V.T. (2001) Water soluble vitamin E derivative protects against radiation induced chromosomal change in mouse bone marrow. ISRH 2001 Satellite Symposium, Radioprotectors for Human Health, July 16, 2001. Kyoto, Japan, Abstract Book, p13.
15. Singh, R. K., Verma, N. C. and Kagiya, V. T. (2001) Effect of water soluble derivative of alpha-tocopherol on radiation response of Saccharomyces cerevisiae, Ind. J. Biochem. Biophys., 38: 399-405.
16. Swenberg, C. E and Speicher, J. M., (1995). Neutron and Gamma-radiation sensitivity of plasmid DNA by plasmid DNA of varying superhelical density. Radiation Res. 144: 301-309
17. Cheong, N.,. Perrault, A. R and Iliakis, G. (1998.)., In vitro rejoining of DNA double strand breaks: a comparison of genomic DNA with plasmid DNA based assays, Int. J. Radiat. Biol., 73: 481-491
18. Yokoya, A., Watanabe, R and Hara, T (1999)Single and double-strand breaks in solid pBR322 plasmid DNA induced by ultrasoft X-rays at photon energies of 388, 435, 573 ev., J. Radiat. Res. 40: 145-158.
19. Sambrook, J., Frittsch, E. F. and. Maniatis, T (1989). Molecular Cloning: A Laboratory manual Volume 1, Cold Spring Harbour Laboratory Press pp 1.42-1.46
20. Sambrook, J.. Fritsch, E. F. and. Maniatis, T. (1989). Molecular Cloning: A Laboratory manual Volume 1, Cold Spring Harbour Laboratory Press pp 6.3-6.17
21. 2 on plasmid DNA,. Mutation Research, 466: 1-7.
22. Nishimoto, S., Ide, H.,. Wada T and. Kagiya, T. (1983). Radiation induced hydroxylation of thymine, promoted by electron - affinic compounds, Int. J. Radiation Biol., 44: 585-600.
23. Nair, C. K. K., Rajagopalan, R., Wani, K., Huilgol, N. G., Kagiya, V. T. and.Kapoor, S Mechanism of radioprotection by TMG- a water soluble vitamin E. J. Radiat. Res. 40. 451. (2000)(Abstract).
24. Spothein-Maurizot, M.,. Ruiz, S., Sebattier R and Charlier M., (1995) Radioprotection of DNA by polyamines, Int. J. Radiat. Biol., 68: 571-577.
25. Waters, R. L., Newton, G. L., Olive, P. L and. Fahey, R. C. (1999). Radioprotection of human cell nuclear DNA by polyamines: Radiosensitivity of chromatin is influenced by tightly bound spermine. Radiation Research, 151: 354-362.
26. Murray, D. (1998) Aminothiols, Chapter 3: In Radioprotectors: Chemical, Biological and Clinical Perspectives ed. E. A. Bump and K. Malakar, CRC press Inc., Boca Raton, Fla., pp53-109.
27. Murray, D and McBride, W. H. (1996) Radioprotective agents. In Kirk-Othmer Enzyclopedia of Chemical Technology, Fourth Edition, Vol 20, John Wiley & Sons Inc., New York, pp 964-1006.
28. Burton, G. W. and Ingold, K. U. (1983) In Protective agents in cancer (McBrien, D. C. H. and Slater T. F., eds), academic Press London and new York, pp 81-92.
29. Borek, C., Ong A., Mason, H., Donahue, L., and Bianglow, J. (1986) Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms. Proc. Natl. Acad. Sci. (USA) 83: 1490-1494.
30. Kapoor, S., Mukherjee, T., Kagiya, V. T. and Nair, C. K. K.(2002), Redox reactions of tocopherol monoglucoside in aqueous solution: a pulse radiolysis study. J. Radiat Res. 43: 99-106.
31. Sy, D., Hugot, S.,. Sarvoye, C., Ruiz, R., Charlier. M., and Maurizot, S. (1999) Radioprotection of DNA by spermine: a molecular modelling appproach, Int. J. Radiat. Biol. 75: 953-961.
32. Halliwell, B. and Gutteridge, J. M. C. (1999).Free radicals in Biology and Medicine, third edition, Oxford Science Publications, Oxford.
33. Pieri, C., Maara, M., Moroni, R., Recchioni, R. and Selli, F. M. (1994). Melatonin: A peroxyl radical scavenger more effective than vitamin E, Life. Sci: 15: 271-276.
34. Vijayalakshmi, R. J. R., Hermann T.S. and Meltz M. L. (1996). Melatonin and radioprotection from genetic damage: In vivo/ in vitro studies with human volunteers, Mutation Res., 371: 221-228.
35. Miura, y, Anzai, K , Ueda, J and Ozawa, T (2000) Novel approach to in vivo screening for Radioprotective Activity in whole Mice: In vivo Electron spin resonance study probing the redox reaction of Nitroxyl. J. Radiat. Res. 41: 103-111.