Transforming growth factor β-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells

International Journal of Cancer

Volumn 105, Issue 6, 2003, Pages 769-778

  Giusti, Corinne ^a   Desruisseau, Sylvie ^a   Ma, Lin ^b   Calvo, Fabien ^b   Martin, Pierre Marie ^a   Berthois, Yolande ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

Amphireguline; Breast cancer; Transforming growth factor 1; Urokinase type plasminogen activator

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMPHIREGULIN; MITOGEN ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1; UROKINASE;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER GROWTH; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

BREAST; CELL LINE, TRANSFORMED; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; OLIGONUCLEOTIDES, ANTISENSE; RNA STABILITY; RNA, MESSENGER; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION; URINARY PLASMINOGEN ACTIVATOR;

EID: 0038795547     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11158     Document Type: Article

References (57)

1. Normanno N, Bianco C, De Luca A, Salomon DS. The role of EGF-related peptides in tumor growth. Front Biosci 2001;6:D685-707.
2. Shoyab M, McDonald VL, Bradley JG, Todaro GJ. Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci USA 1988;85:6528-32.
3. Plowman GD, Green JM, McDonald VL, Neubauer MG, Disteche CM, Todaro GJ, Shoyab M. The amphireguline gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol Cell Biol 1990;10:1969-81.
4. Johnson GR, Prigent SA, Gullick WJ, Stromberg K. Characterization of high and low molecular forms of amphireguline that differ in glycosylation and peptide core length. J Biol Chem 1993;268:18835-43.
5. Johnson GR, Kannan B, Shoyab M, Stromberg K. Amphireguline induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphireguline acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells. J Biol Chem 1993;268:2924-31.
6. Johnson GR, Saeki T, Auersperg N, Gordon AW, Shoyab M, Salomon DS, Stromberg K. Response to and expression of amphireguline by ovarian carcinoma and normal ovarian surface epithelial cells: nuclear localization of endogenous amphireguline. Biochem Biophys Res Comm 1991;180:481-8.
7. Johnson GR, Saeki T, Gordon A, Shoyab M, Salomon DS, Stromberg K. Autocrine action of amphireguline in a colon carcinoma cell line and immunocytochemical localization of amphireguline in human colon. J Cell Biol 1992;118:741-51.
8. Saeki T, Stromberg K, Qi CF, Gullick WJ, Tahara E, Normanno N, Ciardiello, F, Kenney N, Johnson GR, Salomon D. Differential immunohistochemical detection of amphireguline and crypto in human normal colon and colorectal tumors. Cancer Res 1992;52:3467-73.
9. Sehgal I, Bailey J, Hitzemann K, Pittelkow MR, Maihle NJ. Epidermal growth factor receptor-dependent stimulation of amphireguline expression in androgen-stimulated human prostate cancer cells. Mol Biol Cell 1994;5:339-47.
10. Normanno N, Selvam MP, Qi CF, Saeki T, Johnson G, Kim N, Ciardiello F, Shoyab M, Plowman G, Brandt R, Todaro G, Salomon DS. Amphireguline as an autocrine growth factor for c-Ha-ras and c-erbB-2-transformed human mammary epithelial cells. Proc Natl Acad Sci USA 1994;91:2790-4.
11. Normanno N, Qi CF, Gullick WJ, Persico G, Yarden Y, Wen D, Plowman G, Kenney N, Johnson G, Kim N, Brandt R, Martinez-Lacaci I, et al. Expression of amphireguline, cripto-1, and heregulin in human breast cancer cells. Int J Oncol 1993;2:903-911.
12. Visscher DW, Sarkar FH, Kasunic TC, Reddy KB. Clinicopathological analysis of amphireguline and heregulin immunostaining in breast neoplasia. Breast Cancer Res Treat 1997;45:75-80.
13. Ma L, de Roquancourt A, Bertheau P, Chevret S, Millot G, SastreGarau X, Espié M, Marty M, Janin A, Calvo F. Expression of amphireguline and epidermal growth factor receptor in human breast cancer: analysis of autocriny and paracriny. J Pathol 2001;194:412-8.
14. LeJeune S, Leek R, Horak E, Plowman G, Greenall M, Harris AL. Amphireguline, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer. Cancer Res 1993;53:3597-602.
15. Fontanini G, De Laurentiis M, Vignati S, Chine S, Lucchi M, Silvestri V, Mussi A, De Placido S, Tortora G, Bianco AR, Gullick W, Angeletti CA, et al. Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphireguline and microvessel count are independent prognosis indicators of survival. Clin Cancer Res 1998;4:241-9.
16. Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993;73:161-95.
17. Andreasen PA, Egelund R, Petersen HH. The plasminogen activation system in tumor growth, invasion and metastasis. Cell Mol Life Sci 2000;20:25-40.
18. Rabbani SA, Mazar AP. The role of the plasminogen activation system in angiogenesis and metastasis. Surg Oncol Clin N Am 2001;10:393-415.
19. Desruisseau S, Ghazarossian-Ragni E, Chinot O, Martin PM. Divergent effect of TGFβ1 on growth and proteolytic modulation of human prostatic cancer cell lines. Int J Cancer 1996;66:796-801.
20. Teraoka H, Sawada T, Yamashita Y, Nakata B, Ohira M, Ishikawa T, Nishino H, Hirakawa K. TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion. Int. J Oncol 2000;19:709-15.
21. Massague J. The transforming growth factorβ family. Annu Rev Cell Biol 1990, 6:597-641.
22. Barrett-Lee P, Travers M, Luqmani Y, Coombes RC. Transcripts for transforming growth factors in human breast cancer: clinical correlates. Br J Cancer 1990;61:612-7.
23. Bellone G, Carbone A, Tibaudi D, Mauri F, Ferrero I, Smirne C, Suman F, Rivetti C, Migliaretti G, Camandona M, Palestro G, Emanuelli G, et al. Differential expression of transforming growth factorsβ1, -β2 and -β3 in human colon carcinoma. Eur J Cancer 2001;37:224-33.
24. Pepper MS, Berlin D, Montesano R, Orci L, Vassalli JD. Transforming growth factor-β1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol 1990;111:743-55.
25. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitako K. Vascular endothelial growth factor is induced in response to transforming growth factor β in fibroblastic and epithelial cells. J Biol Chem 1994;269:6271-4.
26. Steiner M, Barrak E. Transforming growth factor β1 overproduction in prostate cancer: effects on growth in vivo and in vitro. Mol Endocrinol 1992;6:15-25.
27. Chang H, Gillett N, Figari I, Lopez A, Palladino M, Derynck R. Increased transforming growth factor β expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. Cancer Res 1993;53:4391-8.
28. Ma L, Gauvillé C, Berthois Y, Johnson GR, Calvo F. Antisense expression for amphireguline suppresses tumorigenicity of a transformed human breast epithelial cell line. Oncogene 1999;18:6513-20.
29. Silvy M, Giusti C, Martin PM, Berthois Y. Differential regulation of cell proliferation and protease secretion by epidermal growth factor and amphireguline in tumoral versus normal breast epithelial cells. Br J Cancer 2001;84:936-45.
30. Berthon P, Goubin G, Dutrillaux B, Degeorges A, Faille A, Gespach C, Calvo, F. Single-step transformation of human breast epithelial cells by SV40 large T oncogene. Int J Cancer 1992;52:92-7.
31. Lebeau J, Gerbault-Seureau M, Lemieux N, Apiou F, Calvo F, Berthon P, Goubin G, Dutrillaux B. Loss of chromosome 3p arm differentiating tumorigenic from non-tumorigenic cells derived from the same SV40-transformed human mammary epithelial cells. Int J Cancer 1995;60:244-8.
32. Reinartz J, Batrla R, Boukamp P, Fusenig N, Kramer MD. Binding and activation of plasminogen at the surface of human keratinocytes. Exp Cell Res 1993;208:197-208.
33. Chromszynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
34. Gibson UE, Heid CA, Williams PM. A novel method for real-time quantitative RT-PCR. Genome Res 1996;6:995-1001.
35. Foeckens JA, Schmitt M, van Putten WL, Peters HA, Bontenbal M, Janicke F, Klijn GJ. Prognostic value of urokinase-type plasminogen activator in 671 primary breast cancer patients. Cancer Res 1992;52:6101-5.
36. Duggan C, Maguire T, McDermott E, O'Higgins N, Fennelly JJ, Duffy MJ. Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer. Int J Cancer 1995;61:597-600.
37. Lo RS, Wotton D, Massagué J. Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J 2001;20:128-36.
38. Moriuchi A, Hirono S, Ido A, Ochiai T, Nakama T, Uto H, Hori T, Hayashi K, Tsubouchi H. Additive and inhibitory effects of simultaneous treatment with growth factors on DNA synthesis through MAPK pathway and G1 cyclins in rat hepatocytes. Biochem Biophys Res Comm 2000;280:368-73.
39. Blasi F. Urokinase and Urokinase receptor: a paracrine/autocrine system regulating cell migration and invasiveness. Bioessays 1993;15:105-11.
40. Kimura H. Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity. Proc Natl Acad Sci USA 1993;90:2165-9.
41. Wiedlocha A, Falnes PO, Madshus IH, Sandvig K, Olsnes S. Dual mode of signal transduction by externally added acidic fibroblast growth factor. Cell 1994;76:1039-51.
42. Nanbu R, Menoud PA, Nagamine Y. Multiple instability-regulating sites in the 3′ untranslated region of the urokinase-type plasminogen activator mRNA. Mol Cell Biol 1994;14:4920-8.
43. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. Mechanism of activation of the TGF-β receptor. Nature (Lond) 1994;370:341-7.
44. Souchelnytshyi S, Tamaki K, Engstrom U, Wernstedt C, ten Dijke P, Heldin CH. Phosphorylation of Ser 465 and Ser 467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor β signaling. J Biol Chem 1997;272:28107-15.
45. Abdollah S, Macias-Silva M, Tsukazaki T, Hayashi H, Attisano L, Wrana JL. Tβ RI phosphorylation of Smad2 on Ser 465 and Ser 467 is required for Smad2-Smad4 complex formation and signaling. J Biol Chem 1997;272:27678-5.
46. Santibanez JF, Iglesias M, Frontelo P, Martinez J, Quintanilla M. Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor β1 in transformed keratinocytes. Biochem Biophys Res Comm 2000;273:521-7.
47. Yue J, Mulder KM. Requirement of Ras/MAPK pathway activation by transforming growth factor β for transforming growth factor β1 production in a Smad-dependent pathway. J Biol Chem 2000;275:30765-73.
48. Simeone DM, Zhang L, Graziano K, Nicke B, Pham T, Schaefer C, Logsdon CD. Smad4 mediates activation of mitogen-activated protein kinases by TGFβ in pancreatic acinar cells. Am J Physiol Cell Physiol 2001;281:C311-19.
49. Bonnet H, Filhol O, Truchet I, Brethenou P, Cochet C, Amalric F, Bouche G. Fibroblast Growth factor-2 binds to the regulatory β subunit of CK2 and directly stimulates CK2 activity toward nucleolin. J Biol Chem 1996;271:24781-7.
50. Massagué J, Wotton D. Transcriptional control by the TGFβ/Smad signaling system EMBO J 2000;19:1745-54.
51. Lengyel E, Gum R, Stepp E, Juarez J, Wang H, Boyd D. Regulation of urokinase-type plasminogen activator expression by an ERK1dependent signaling pathway in a squamous cell carcinoma cell line. J Cell Biochem 1996;61:430-8.
52. Rorth P, Nerlov C, Blasi F, Johnsen M. Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester. Nucleic Acids Res 1990;18:5009-17.
53. Wong C, Rougier-Chapman EM, Frederick JP, Datto MB, Liberati NT, Li JM, Wang XF. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β. Mol Cell Biol 1999;19:1821-30.
54. Lopez-Rovira T, Chalaux E, Rosa JL, Bartrons R, Ventura F. Interaction and functional cooperation of NF-κB with Smads. Transcriptional regulation of the junB promoter. J Biol Chem 2000;275:28937-46.
55. Kon A, Vindevoghel L, Kouba DJ, Fujimura Y, Uitto J, Mauviel F. Cooperation between SMAD and NF-κB in growth factor regulated Type VII collagen gene expression. Oncogene 1999;18:1837-44.
56. Liu X, Yue J, Frey RS, Zhu Q, Mulder KM. TGFβ signaling through Smad1 in human breast cancer cells. Cancer Res 1998;58:4752-7.
57. Kretzchmar M, Doody J, Timokhina I, Massagué J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999;13:804-16.