ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans

Clinical Genetics

Volumn 62, Issue 3, 2002, Pages 226-229

  Weggemans, Rianne M ^a   Zock, P L ^b   Tai, E S ^c   Ordovas, J M ^c   Molhuizen, H O F ^a   Katan, M B ^b,d  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^b TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^c TUFTS UNIVERSITY   (United States)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

ABCG5; Dietary fat; Dietary response; Genetic polymorphisms; Lipids

Indexed keywords

ABC TRANSPORTER; CHOLESTEROL; CYTOSINE; GUANINE;

ADULT; ALLELE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL INTAKE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; INTESTINE ABSORPTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ATP-BINDING CASSETTE TRANSPORTERS; BODY MASS INDEX; CHOLESTEROL; FEMALE; HUMANS; LIPOPROTEINS; MALE; POLYMORPHISM, GENETIC;

EID: 0036766742     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2002.620307.x     Document Type: Article

References (8)

1. Berge KE, Tian H, Graf GA et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000: 290: 1771-1775.
2. Lee MH, Lu K, Hazard S et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet 2001: 27: 79-83.
3. Beynen AC, Katan MB, van Zutphen L. Hypo- and hyperresponders: individual differences in the response of serum cholesterol concentration to changes in diet. Adv Lipid Res 1987: 22: 115-171.
4. Weggemans RM, Zock PL, Urgert R, Katan MB. Differences between men and women in response of serum cholesterol to dietary changes. Eur J Clin Invest 1999: 29: 827-834.
5. Kleinbaum DG, Kupper LL, Morgenstern H. Applied regression analysis and other multivariable methods. Belmont: Duxbury Press, 1988.
6. Weggemans RM, Zock PL, Ordovas JM, Pedro-Botet J, Katan MB. Apoprotein E genotype and the response of serum cholesterol to dietary fat, cholesterol and cafestol. Atheroscler 2001: 154: 547-555.
7. Denke MA, Frantz ID Jr. Response to a cholesterol-lowering diet: efficacy is greater in hypercholesterolemic subjects even after adjustment for regression to the mean. Am J Med 1993: 94: 626-631.
8. de Roos B, Katan MB. Possible mechanisms underlying the cholesterol-raising effect of the coffee diterpene cafestol. Curr Opin Lipidol 1999: 10: 41-45.