Engineering of a staphylokinase-based fibrinolytic agent with antithrombotic activity and targeting capability toward thrombin-rich fibrin and plasma clots

Journal of Biological Chemistry

Volumn 278, Issue 29, 2003, Pages 26677-26686

  Lian, Qun ^a   Szarka, Steven J ^b   Ng, Kenneth K S ^a   Wong, Sui Lam ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b SemBioSys Genetics Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; COENZYMES; ORGANIC ACIDS; PLANTS (BOTANY);

FEEDBACK REPRESSION;

BIOCHEMISTRY;

FIBRINOGEN; FIBRINOLYTIC AGENT; HIRUDIN; HIRUDIN E COIL STAPHYLOKINASE K COIL HETERODIMER; STAPHYLOKINASE; THROMBIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTICOAGULATION; ARTICLE; BACILLUS SUBTILIS; BLOOD CLOT LYSIS; CONCENTRATION RESPONSE; DIMERIZATION; DISULFIDE BOND; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME ENGINEERING; FIBRIN CLOT; FIBRINOLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN;

BACILLUS SUBTILIS; BASE SEQUENCE; BLOOD COAGULATION; DISULFIDES; DNA, RECOMBINANT; DRUG DESIGN; FIBRIN; FIBRINOLYTIC AGENTS; HIRUDINS; HUMANS; MASS SPECTROMETRY; METALLOENDOPEPTIDASES; MOLECULAR STRUCTURE; PROTEIN ENGINEERING; THROMBIN; THROMBOSIS;

BACILLUS SUBTILIS;

EID: 0038712499     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303241200     Document Type: Article

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