Rapid molecular testing for bioterrorism agents: Targets, tactics, and technology

Journal of Clinical Ligand Assay

Volumn 25, Issue 4, 2002, Pages 348-357

  Payne, Deborah Ann ^a   Petersen, John ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NONE

Author keywords

Bed side testing; DNA; Infectious; Molecular diagnostics; Nucleic acid testing (NAT); Polymerase chain reaction (PCR); Rapid thermocylcer; RNA; Terrorism

Indexed keywords

BIOLOGICAL WARFARE; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; ELECTROCHEMISTRY; NUCLEIC ACID ANALYSIS; POINT OF CARE TESTING; POLYMERASE CHAIN REACTION; REVIEW;

EID: 0038675414     PISSN: 10811672     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (60)

1. Nass M: The labyrinth of biological defense. The PSR Quarterly. 1991; Vol.1, p. 24.
2. North CS, Pfefferbaum B: Research on the mental health effects of terrorism. JAMA 2002;288(5):633-636.
3. Inglesby TV, O'Toole T, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Friedlander AM, Gerberding J, Hauer J, Hughes J, McDade J, Osterholm MT, Parker G, Perl TM, Russell PK, Tonat K: Anthrax as a biological weapon, 2002: updated recommendations for management. JAMA 2002;287(17):2236-2252.
4. Niiler E: Bioterrorism - biotechnology to the rescue? Na. Biotechnol 2002;20(1):21-25
5. www.niaid.nih.gov/dmid/bioterrorism/bandc_priority.
6. www.bt.cdc.gov/Agent/Agentlist.asp.
7. Bronze MS, Huycke MM, Machado LJ, Voskuhl GW, Greenfield RA: Viral agents as biological weapons and agents of bioterrorism. Am J Med Sci 2002;323(6):316-325.
8. Enserink M: This Time It Was Real: Knowledge Of Anthrax Put to the Test. Science 2001;294:490-491.
9. Grinberg LM, Abramova FA, Yampolskaya OV, Walker DH, Smith JH: Quantitative pathology of inhalational anthrax I: quantitative microscopic findings. Mod Pathol 2001;14(5):482-495.
10. Walker DH, Yampolska O, Grinberg LM: Death at Sverdlovsk: what have we learned? Am J Pathol 1994;144(6):1135-1141.
11. Abramova FA, Grinberg LM, Yampolskaya OV, Walker DH: Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979. Proc Natl Acad Sci U S A 1993;90(6):2291-2294.
12. Torok TJ, Tauxe RV, Wise RP, Livengood JR, Sokolow R, Mauvais S, Birkness KA, Skeels MR, Horan JM, Foster LR: A large community outbreak of salmonellosis caused by intentional contamination of restaurant salad bars. JAMA 1997;278(5):389-395.
13. Varkey P, Poland GA, Cockerill FR 3rd, Smith TF, Hagen PT: Confronting bioterrorism: physicians on the front line. Mayo Clin Proc 2002;77(7):661-672.
14. Horton HH, Misrahi JJ, Matthews GW, Kocher PL. Critical biological agents: disease reporting as a tool for determining bioterrorism preparedness. J Law Med Ethics 2002;30(2):262-266.
15. Gerberding JL, Hughes JM, Koplan JP: Bioterrorism preparedness and response: clinicians and public health agencies as essential partners. JAMA 2002;287(7):898-900.
16. Torpy JM: New threats and old enemies: challenges for critical care medicine. JAMA 2002;287(12):1513-1515.
17. From the Centers for Disease Control and Prevention. Public health dispatch: update: cutaneous anthrax in a laboratory worker-Texas, 2002. JAMA 2002;288(4):444.
18. Gage KL, Dennis DT, Orloski KA, Ettestad P, Brown TL, Reynolds PJ, Pape WJ, Fritz CL, Carter LG, Stein JD: Cases of catassociated human plague in the Western US, 1977-1998. Clin Infect Dis 2000;30(6):893-900.
19. Conway C: Food safety. Nurs Stand 2001;15(41):47-52; quiz 54-5.
20. Texas Animal Health Commission. July 2001.
21. Katz DJ, Cruz MA, Trepka MJ, Suarez JA, Fiorella PD, Hammond RM: An outbreak of typhoid Fever in Florida associated with an imported frozen fruit. J Infect Dis 2002;186(2):234-239.
22. Sumner J, Ross T: A semi-quantitative seafood safety risk assessment. Int J Food Microbiol 2002 Jul 25;77(1-2):55-59.
23. Henderson DA:The looming threat of bioterrorism. Science 1999;26;283(5406):1279-1282.
24. Uhl JR, Bell CA, Sloan LM, Espy MJ, Smith TF, Rosenblatt JE, Cockerill FR 3rd: Application of rapid-cycle real-time polymerase chain reaction for the detection of microbial pathogens: the Mayo-Roche Rapid Anthrax Test. Mayo Clin Proc 2002 Jul;77(7):673-680.
25. Espy MJ, Uhl JR, Sloan LM, Rosenblatt JE, Cockerill FR 3rd, Smith TF: Detection of vaccinia virus, herpes simplex virus, varicella-zoster virus, and Bacillus anthracis DNA by LightCycler polymerase chain reaction after autoclaving: implications for biosafety of bioterrorism agents. Mayo Clin Proc 2002;77(7):624-628.
26. Sloan LM, Hopkins MK, Mitchell PS, Vetter EA, Rosenblatt JE, Harmsen WS, Cockerill FR, Patel R: Multiplex LightCycler PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis in nasopharyngeal specimens. J Clin Microbiol 2002;40(1):96-100.
27. Qian Q, Tang YW, Kolbert CP, Torgerson CA, Hughes JG, Vetter EA, Harmsen WS, Montgomery SO, Cockerill FR 3rd, Persing DH: Direct identification of bacteria from positive blood cultures by amplification and sequencing of the 16S rRNA gene: evaluation of BACTEC 9240 instrument true-positive and false-positive results. J Clin Microbiol 2001;39(10):3578-3582.
28. Hayden RT, Uhl JR, Qian X, Hopkins MK, Aubry MC, Limper AH, Lloyd RV, Cockerill FR: Direct detection of Legionella species from bronchoalveolar lavage and open lung biopsy specimens: comparison of LightCycler PCR, in situ hybridization, direct fluorescence antigen detection, and culture. J Clin Microbiol 2001;39(7):2618-2626.
29. Espy MJ, Rys PN, Wold AD, Uhl JR, Sloan LM, Jenkins GD, Ilstrup DM, Cockerill FR 3rd, Patel R, Rosenblatt JE, Smith TF: Detection of herpes simplex virus DNA in genital and dermal specimens by LightCycler PCR after extraction using the IsoQuick, MagNA Pure, and BioRobot 9604 methods. J Clin Microbiol 2001;39(6):2233-2236.
30. Zheng X, Kolbert CP, Varga-Delmore P, Arruda J, Lewis M, Kolberg J, Cockerill FR, Persing DH: Direct mecA detection from blood culture bottles by branched-DNA signal amplification. J Clin Microbiol 1999;37(12):4192-4193.
31. Cockerill FR 3rd: Conventional and genetic laboratory tests used to guide antimicrobial therapy. Mayo Clin Proc 1998;73(10): 1007-1021.
32. Louie M, Cockerill FR 3rd: Susceptibility testing. Phenotypic and genotypic tests for bacteria and mycobacteria. Infect Dis Clin North Am 2001;15(4):1205-1226.
33. Cockerill FR 3rd: Genetic methods for assessing antimicrobial resistance. Antimicrob Agents Chemother 1999;43(2):199-212.
34. Hanna GJ: HIV-1 genotypic and phenotypic resistance. Clin Lab Med 2002;22(3):637-649.
35. Bradaric N, Punda-Polic V: Cutaneous anthrax due to penicillin-resistant Bacillus anthracis transmitted by an insect bite. Lancet 1992;340(8814):306-307.
36. Patel R, Piper K, Cockerill FR 3rd, Steckelberg JM, Yousten AA: The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster. Antimicrob Agents Chemother 2000;44(3):705-709.
37. Borzenkov VM, Pomerantsev AP, Ashmarin IP: The additive synthesis of a regulatory peptide in vivo: the administration of a vaccinal Francisella tularensis strain that produces beta-endorphin. Biull Eksp Biol Med 1993;116(8):151-153.
38. Robertson DL, Leppla SH: Molecular cloning and expression in Escherichia coli of the lethal factor gene of Bacillus anthracis. Gene 1986;44(1):71-78
39. Bowen JE, Quinn CP: The native virulence plasmid combination affects the segregational stability of a theta-replicating shuttle vector in Bacillus anthracis var. New Hampshire. J Appl Microbiol 1999;87(2):270-278.
40. Pezard C, Duflot E, Mock M: from the Laboratoire de Genetique Moleculaire des Toxines, Institut Pasteur, Paris: Constructing of Bacillus anthracis mutant strains producing a single toxin component. J Gen Microbiol 1993;139:2459-2463.
41. Pomerantsev AP, Staritsyn NA: Behaviour of heterologous recombinant plasmid pCET in cells of Bacillus anthracis. Genetika 1996;32:500-509.
42. Pomerantsev AP, Staritsin NA, Mockov YV, Marinin LI: Expression of cereolysine ab genes in Bacillus anthracis vaccine strain ensures protection against experimental hemolytic anthrax infection. Vaccine 1997;15(17-18):1846-1850.
43. Patel R, Allen SL, Manahan JM, Wright AJ, Krom RA, Wiesner RH, Persing DH, Cockerill FR, Thompson RL: Natural history of vancomycin-resistant enterococcal colonization in liver and kidney transplant recipients. Liver Transpl 2001;7(1):27-31.
44. Ishihara S, Yabuta R, Tokura Y, Ohshima K, Tagawa S: Hypersensitivity in mosquito bites is not an allergic disease but an Epstein Barr virus associated lymphoproliferative disease. Int J Hematol 2000;72:223-228.
45. Strizhkov BN, Drobyshev AL, Mikhailovich VM, Mirzabekov AD: PCR amplification on a microarray of gel-immobilized oligonucleotides: detection of bacterial toxin-and drug-resistant genes and their mutations. Biotechniques 2000;29(4):844-848, 850-852, 854 passim.
46. He B, Munson AE, Meade BJ: Analysis of gene expression induced by irritant and sensitizing chemicals using oligonucleotide arrays. Int Immunopharmacol 2001;1(5):867-879.
47. Stefanaki IM, Tosca AD, Themelis GC, Vazgiouraki EM, Dokianakis DN, Panayiotidis JG, Spandidos DA, Balas CJ: In vivo detection of human papilloma virus-induced lesions of anogenital area after application of acetic acid: a novel and accurate approach to a trivial method. J Photochem Photobiol B 2001;65(2-3): 115-121.
48. Hoffman D, Hesselberth J, Ellington AD: Switching nucleic acids for antibodies. Nat Biotechnol 2001;19(4):313-314.
49. Jenne A, Hartig JS, Piganeau N, Tauer A, Samarsky DA, Green MR, Davies J, Famulok M: Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology. Nat Biotechnol 2001;19(1):56-61.
50. DeWitt N: A screen for ribozyme inhibitors. Nat Biotechnol 2001 Jan;19(1):9.
51. Somsen GW, Welten HT, Mulder FP, Swart CW, Kema IP, de Jong GJ: Capillary electrophoresis with laser induced flourescence detection for fast and reliable apolipoprotein E genotyping. J Chromatogr B 2002;775(1):17-26.
52. Crawford EL, Peters GJ, Noordhuis P, Rots MG, Vondracek M, Grafstrom RC, Lieuallen K, Lennon G, Zahorehak R, Georgeson MJ, Wall A, Lechner JF, Fan PS, Kahaleh MB, Khuder SA, Warner KA, Weaver DA, Willey JC: Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR. Mol Diagn 2001;6:217-225.
53. Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, Weaver DA, Ferencak WJ, Jennings CA, Hammersley JR, Olson DA, Willey JC: Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res 2001;60(5):1609-1618.
54. Yang L, Tran DK, Wang X: BADGE, Beads Array for the Detection of Gene Expression, a high-throughput diagnostic bioassay. Genome Res 2001;11(11):1888-1898.
55. Ye F, Li MS, Taylor JD, Nguyen Q, Colton HM, Casey WM, Wagner M, Weiner MP, Chen J: Fluorescent microsphere-based readout technology for multiplexed human single nucleotide polymorphism analysis and bacterial identification. Hum Mutat 2001;17(4):305-316.
56. Taylor JD, Briley D, Nguyen Q, Long K, Iannone MA, Li MS, Ye F, Afshari A, Lai E, Wagner M, Chen J, Weiner MP: Flow cytometric platform for high-throughput single nucleotide polymorphism analysis. Biotechniques 2001;30(3):661-666;668-669.
57. Martin C, Roberts D, van Der Weide M, Rossau R, Jannes G, Smith T, Maher M: Development of a PCR based line probe assay for identification of fungal pathogens. J Clin Microbiol 2000;38(10):3735-3742.
58. Liu Y, Rauch CB, Stevens RL, Lenigk R, Yang J, Rhine DB, Grodzinski P: DNA amplification and hybridization assays in integrated plastic monolithic devices. Anal Chem 2002;74(13):3063-3070.
59. Umek RM, Lin SW, Vielmetter J, Terbrueggen RH, Irvine B, Yu CJ, Kayyem JF, Yowanto H, Blackburn GF, Farkas DH, Chen YP: Electronic detection of nucleic acids: a versatile platform for molecular diagnostics. J Mol Diagn 2001;3(2):74-84.
60. Puchhammer-Stockl E, Steininger C, Geringer E, Heinz FX: Comparison of virtual phenotype and HIV-SEQ program (Stanford) interpretation for predicting drug resistance of HIV strains. HIV Med 2002;3(3):200-206.