Genetic basis of tissue specificity of vasculitis in MRL/lpr mice

Arthritis and Rheumatism

Volumn 48, Issue 5, 2003, Pages 1445-1451

  Yamada, Akihiro ^a   Miyazaki, Tatsuhiko ^a   Lu, Ling Min ^a   Ono, Masao ^a   Ito, Mitsuko R ^a   Terada, Miho ^a   Mori, Shiro ^b   Hata, Kazuya ^c   Nozaki, Yoshimi ^c   Nakatsuru, Shuichi ^d   Nakamura, Yusuke ^e   Onji, Morikazu ^a   Nose, Masato ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c 2 1 T   (Japan)

^d Kobe MI R and D Center   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTERY DIAMETER; ARTICLE; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME 8; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; GENE CONTROL; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HEREDITY; HISTOPATHOLOGY; KIDNEY DISEASE; MALE; MICROSATELLITE MARKER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIMPLE SEQUENCE REPEAT; TISSUE DISTRIBUTION; VASCULITIS;

ANIMALS; AORTA; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; LOD SCORE; MALE; MICE; MICE, INBRED C3H; MICE, INBRED MRL LPR; MICROSATELLITE REPEATS; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; QUANTITATIVE TRAIT LOCI; VASCULITIS;

EID: 0038666540     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10952     Document Type: Article

References (23)

1. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med 1997;337:1512-23.
2. Ansell BM, Bacon PA, Lie JT, Yazici H. The vasculitides. London: Chapman & Hall; 1996.
3. Murphy ED, Roths JB. Autoimmunity and lymphoproliferation: induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice. In: Rose NR, Bigazzi PE, Warner NL, editors. Genetic control of autoimmune disease. New York: Elsevier North Holland; 1978. p. 207-20.
4. Nose M, Nishimura M, Kyogoku M. Analysis of granulomatous arteritis in MRL/Mp autoimmune disease mice bearing lymphoproliferative genes: the use of mouse genetics to dissociate the development of arteritis and glomerulonephritis. Am J Pathol 1989;135:271-80.
5. Taniguchi Y, Ito MR, Mori S, Yonehara S, Nose M. Role of macrophages in the development of arteritis in MRL strains of mice with a deficit in Fas-mediated apoptosis. Clin Exp Immunol 1996;106:26-34.
6. Nakatsuru S, Terada M, Nishihara M, Kamogawa J, Miyazaki T, Qu WM, et al. Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. Pathol Int 1999;49:974-82.
7. Qu WM, Miyazaki T, Terada M, Lu LM, Nishihara M, Yamada A, et al. Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele. Eur J Immunol 2000;30:2027-37.
8. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-7.
9. Morris JA, Gardner MJ. Calculating confidence intervals for relative risks (odds ratios) and standardized ratios and rates. BMJ 1988;296:1313-6.
10. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, et al. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1987;1:174-81.
11. Apelgren LD, Bailey DL, Fouts RL, Short L, Bryan N, Evans GF, et al. The effect of a selective estrogen receptor modulator on the progression of spontaneous autoimmune disease in MRL/lpr mice. Cell Immunol 1996;173:55-63.
12. McMurray RW. Prolactin in murine systemic lupus erythematosus. Lupus 2001;10:742-7.
13. Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol 1985;37:269-390.
14. Nose M, Nishihara M, Kamogawa J, Terada M, Nakaturu S. Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci. Rev Immunogenet 2000;2:154-64.
15. Nishihara M, Terada M, Kamogawa J, Ohashi Y, Mori S, Nakatsuru S, et al. Genetic basis of autoimmune sialoadenitis in MRL/lpr lupus mice: additive and hierarchical properties of polygenic inheritance. Arthritis Rheum 1999;42:2616-23.
16. Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, et al. Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum 2002;46:1067-74.
17. Yin TG, Schendel P, Yang YC. Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. J Exp Med 1992;175:211-6.
18. Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, et al. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A 1996;93:14002-7.
19. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002;168:5699-708.
20. Wu C, Ferrante J, Gately MK, Magram J. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J Immunol 1997;159:1658-65.
21. Wu C, Wang X, Gadina M, O'Shea JJ, Presky DH, Magram J. IL-12 receptor β2 (IL-12Rβ2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J Immunol 2000;165:6221-8.
22. Huang FP, Feng GJ, Lindop G, Stott DI, Liew FY. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL-lpr mice. J Exp Med 1996;183: 1447-59.
23. Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T, et al. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 1996;97:1597-604.