Random mutagenesis of PDZomi domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis

Oncogene

Volumn 22, Issue 18, 2003, Pages 2772-2781

  Junqueira, Daniela ^a   Cilenti, Lucia ^a   Musumeci, Lucia ^a   Sedivy, John M ^b   Zervos, Antonis S ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Apoptosis; Myc proto oncogene; Omi HtrA2; PDZ domains; Protein design; Protein protein interactions; Yeast two hybrid system

Indexed keywords

CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; MITOCHONDRIAL ENZYME; MUTANT PROTEIN; MYC PROTEIN; SERINE PROTEINASE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; FIBROBLAST; GENE INACTIVATION; HUMAN; HUMAN CELL; MAMMAL CELL; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; ONCOGENE C MYC; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTO ONCOGENE; TWO HYBRID SYSTEM;

AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; DNA PRIMERS; HELA CELLS; HUMANS; KINETICS; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RESTRICTION MAPPING; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES;

ANIMALIA; MAMMALIA;

EID: 0038631772     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206359     Document Type: Article

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