Enhanced liposomal transfection through the application of sexsteroids in gynecological cancer cells;Die sexualsteroid-vermittelte verstärkung liposomaler transfektion gynäkologischer krebszellen: Ein neuer ansatz für ein selektives targeting in der gentherapie?

Zentralblatt fur Gynakologie

Volumn 125, Issue 1, 2003, Pages 1-5

  Koster F ^a   Finas, D ^a   Saupp, A ^a   Schulz, C ^a   Diedrich, K ^a   Hauser, C ^b   Felberbaum, Ricardo ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b Octagene Biomed Laboratories GmbH   (Germany)

Author keywords

Liposomal transfection; Sexual steroids; T 47D human breast cancer cell line

Indexed keywords

CHOLESTEROL; CYCLODEXTRIN; ESTROGEN; HORMONE RECEPTOR; HYDROCORTISONE; LIPOSOME; LUCIFERASE; NUCLEAR PROTEIN; PLASMID DNA; PROGESTERONE; SEX HORMONE; TESTOSTERONE;

BREAST CANCER; CANCER CELL CULTURE; CELL NUCLEUS; DOSE RESPONSE; ENDOMETRIUM CANCER; ENZYME ACTIVITY; GENE THERAPY; GENETIC TRANSFECTION; GYNECOLOGIC CANCER; HUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE; REVIEW;

BREAST NEOPLASMS; DRUG CARRIERS; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENES, REPORTER; GENITAL NEOPLASMS, FEMALE; GONADAL STEROID HORMONES; HUMANS; LIPOSOMES; LUCIFERASES; QUATERNARY AMMONIUM COMPOUNDS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0038608744     PISSN: 00444197     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-40363     Document Type: Review

References (16)

1. Baumann CT, Lim CS, Hager GL. Intracellular localization and trafficking of steroid receptors. Cell Biochem Biophys 1999; 31 (2): 119-127
2. Bernasconi AG, Rebuffat AG, Lovati E, Frey BM, Frey FJ, Galli I. Cortisol increases transfection efficiency of cells. FEBS Lett 1997; 419 (1): 103-106
3. Dean DA, Dean BS, Muller S, Smith LC. Sequence requirements for plasmid nuclear import. Exp Cell Res 1999; 253 (2): 713-722
4. Hager GL, Smith CL, Fragoso G, Wolford R, Walker D, Barsony J, Htun H. Intranuclear trafficking and gene targeting by members of the steroid/ nuclear receptor superfamily. J Steroid Biochem Mol Biol 1998; 65 (1-6): 125-132
5. Jain PT, Seth P, Gewirtz DA. Estradiol enhances liposome-mediated uptake, preferential nuclear accumulation and functional expression of exogenous genes in MDA-MB231 breast tumor cells. Biochim Biophys Acta 1999; 1451 (2-3): 224-232
6. Koster F, Felberbaum R, Finas D, Wunsch K, Schulz C, Diedrich K, Hauser C. Progesterone and estradiol enhance lipid mediated transfection of Sk-Br-3 mammarian cancer cells. Int J Mol Med 2002; 9 (6): 617-612
7. Lawrencia C, Mahendran R, Esuvaranathan K. Transfection of urothelial cells using methyl-beta-cyclodextrin solubilized cholesterol and Dotap. Gene Ther 2001; 8 (10): 760-768
8. Li S, Huang L. Nonviral gene therapy: promises and challenges. Gene Ther 2000; 7 (1): 31-34
9. Ma H, Diamond SL. Nonviral gene therapy and its delivery systems. Curr Pharm Biotechnol 2001; 2 (1): 1-17
10. Nikol S, Hallek M. Therapie mit Genen: Erfahrungen und Zukunftsperspektiven 10 Jahre nach ihrer klinischen Einführung. In: Raem AM (Hrsg). GenMedizin. Springer Verlag, Heidelberg 2002; 267-331
11. Rebuffat A, Bernasconi A, Ceppi M, Wehrli H, Verca SB, Ibrahim M, Frey BM, Frey FJ, Rusconi S. Selective enhancement of gene transfer by steroid-mediated gene delivery. Nat Biotechnol 2001; 19 (12): 1155-1161
12. Rebuffat AG, Nawrocki AR, Nielsen PE, Bernasconi AG, Bernal-Mendez E, Frey BM, Frey FJ. Gene delivery by a steroid-peptide nucleic acid conjugate. Faseb J 2002; 16 (11): 1426-1428
13. Subramanian A, Ranganathan P, Diamond SL. Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells. Nat Biotechnol 1999; 17 (9): 873-877
14. Templeton NS, Lasic DD, Frederik PM, Strey HH, Roberts DD, Pavlakis GN. Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol 1997; 15 (7): 647-652
15. Vacik J, Dean BS, Zimmer WE, Dean DA. Cell-specific nuclear import of plasmid DNA. Gene Ther 1999; 6 (6): 1006-1014
16. Wiseman JW, Goddard CA, Colledge WH. Steroid hormone enhancement of gene delivery to a human airway epithelial cell line in vitro and mouse airways in vivo. Gene Ther 2001; 8 (20): 1562-1571