Estradiol enhances liposome-mediated uptake, preferential nuclear accumulation and functional expression of exogenous genes in MDA-MB231 breast tumor cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1451, Issue 2-3, 1999, Pages 224-232

  Jain, Pramod T ^a   Seth, Prem ^b   Gewirtz, David A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Breast tumor; Estradiol; Liposome; Nuclear accumulation; p53

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; LIPOSOME; LUCIFERASE; PROTEIN P53;

APOPTOSIS; ARTICLE; BREAST TUMOR; CELL FRACTIONATION; CELL NUCLEUS; CYTOPLASM; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BREAST NEOPLASMS; CELL NUCLEUS; ESTRADIOL; GENE EXPRESSION REGULATION; GENES, P53; GENES, VIRAL; IN SITU NICK-END LABELING; LIPOSOMES; LUCIFERASES; MICROSCOPY, PHASE-CONTRAST; SIMIAN VIRUS 40; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032731673     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(99)00094-4     Document Type: Article

References (18)

1. Verma I.M., Somai N. Gene therapy - promises, problems and prospects [news]. Nature. 389:1997;239-242.
2. Felgner P.L., Gadek T.R., Holm M., Roman R., Chan H.W., Wenz M., Northrop J.P., Ringold G.M., Danielsen M. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA. 84:1987;7413-7417.
3. Stewart M.J., Plautz G.E., Del Buono L., Yang Z.Y., Xu L., Gao X., Huang L., Nabel E.G., Nabel G.J. Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice. Hum. Gene Ther. 3:1992;649-656.
4. Jain P.T., Gewirtz D.A. Estradiol enhances gene delivery to human breast tumor cells. J. Mol. Med. 76:1998;709-714.
5. Jain P.T., Gewirtz D.A. Sustained improvement of liposomal gene delivery to human breast cancer cells by ionizing radiation. Int. J. Radiat. Biol. 75:1999;217-223.
6. Horwitz K.B., Zava D.T., Thilagar A.K., Jensen E.M., McGuire W.L. Steroid receptor analysis of nine human breast cancer cell lines. Cancer Res. 38:1978;2434-2437.
7. Reddel R.R., Sutherland R.L. Effects of pharmacological concentrations of estradiol on proliferation and cell cycle kinetics of human breast cancer cell lines in vitro. Cancer Res. 47:1987;5323-5329.
8. Bartek J., Iggo R., Gannon J., Lane D.P. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene. 5:1990;893-899.
9. Li R., Sutphin P.D., Schwartz D., Matas D., Almog N., Wolkowicz R., Goldfinger N., Pie H., Prococimer M., Rotter V. Mutant p53 protein expression interferes with p53-independent apoptotic pathways. Oncogene. 16:1998;3269-3277.
10. Han J.W., Dionne C.A., Kedersha N.L., Goldmacher V.S. P53 status affects the rate of onset of but not the overall extent of doxorubicin-induced cell death in rat-1 fibroblasts constitutively expressing c-Myc. Cancer Res. 57:1997;176-182.
11. Katayose D., Gudas J., Nguyen H., Srivastva S., Cowan K.H., Seth P. Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells. J. Clin. Cancer Res. 1:1995;889-897.
12. Jain P.T., Gewirtz D.A. Enhancement of liposomal gene delivery in human breast cancer cells by dimethyl sulfoxide. Int. J. Mol. Med. 1:1998;609-611.
13. Jain P.T., Pento J.T. A vehicle for the evaluation of hydrophobic compounds in cell culture. Res. Commun. Pathol. Pharmacol. 74:1991;105-116.
14. Jain P.T., Pento J.T., Graves D.C. Cell-growth quantitation methods for evaluating antiestrogens in human breast cancer cells in culture. J. Pharmacol. Methods. 27:1992;203-207.
15. Hirt B. Selective extraction of polyoma DNA from infected mouse cell culture. J. Mol. Biol. 26:1967;365-369.
16. Jain J.P.T., Trump B.F. Novel mechanism of estrogen action in human breast cancer cells. Anticancer Drugs. 8:1997;1-5.
17. Clarke R., van den Berg H.W., Murphy R.F. Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17 beta-estradiol. J. Natl. Cancer Inst. 82:1990;1702-1705.
18. Rao P.N., Engelberg J. Structural specificity of estrogens in the induction of mitotic chromatid non-disjunction in HELA cells. Exp. Cell Res. 48:1967;71-81.