Inward and outward potassium currents through the same chimeric human Kv channel

European Biophysics Journal

Volumn 32, Issue 2, 2003, Pages 113-121

  Varshney, Anurag ^a   Mathew, M K ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

Activation; Mutagenesis; Potassium channel; Voltage sensing

Indexed keywords

ION CHANNEL; KCNA1 CHANNEL; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.4; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHIMERA; HUMAN; ION CURRENT; METABOLISM; MUTATION; OOCYTE; PHYSIOLOGY; POTASSIUM CURRENT; SENSOR; STRUCTURE ACTIVITY RELATION; TECHNIQUE; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0038575704     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-002-0272-9     Document Type: Article

References (45)

1. Aldrich RW, Hoshi T, Zagotta WN (1990) Differences in gating among amino-terminal variants of Shaker potassium channels. Cold Spring Harb Symp Quant Biol 55:19-27
2. Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR (1997) NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. Nature 385:272-275
3. Bezanilla F (2000) The voltage sensor in voltage-dependent ion channels. Physiol Rev 80:555-592
4. Bockenhauer D, Zilberberg N, Goldstein SA (2001) KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci 4:486-491
5. Cha A, Snyder GE, Selvin PR, Bezanilla F (1999) Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature 402:809-813
6. Chanda B, Mathew MK (1999) Functional reconstitution of bacterially expressed human potassium channels in proteoliposomes: membrane potential measurements with JC-1 to assay ion channel activity. Biochim Biophys Acta 1416:92-100
7. Chanda B, Tiwari JK, Varshney A, Mathew MK (1999a) Exploring the architecture of potassium channels using chimeras to reveal signal transduction. Biosci Rep 9:301-306
8. + channel. Neuroreport 10:237-241
9. Chen J, Mitcheson JS, Tristani-Firouzi M, Lin M, Sanguinetti MC (2001) The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Proc Natl Acad Sci USA 98:11277-11282
10. Choe S, Kreusch A, Pfaffinger PJ (1999) Towards the three-dimensional structure of voltage-gated potassium channels. Trends Biochem Sci 24:345-349
11. Glauner KS, Mannuzzu LM, Gandhi CS, Isacoff EY (1999) Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature 402:813-817
12. Hille B (2001) Ionic channels of excitable membranes, 3rd edn. Sinauer, Sunderland, Mass., USA
13. + channel can be trapped in the open state by an intersubunit metal bridge. Neuron 21:617-621
14. + channels. J Neurosci 14:1385-1393
15. Hopkins WF, Allen M, Tempel BL (1999) Interactions of snake dendrotoxins with potassium channels. Methods Enzymol 294:649-661
16. + channel. Biochemistry 39:10347-10352
17. Kreusch K, Pfaffinger PJ, Stevens CF, Choe S (1998) Crystal structure of the tetramerization domain of Shaker potassium channel. Nature 392:945-948
18. + channel from Arabidopsis thaliana, possesses an intrinsic voltage sensor. Biophys J 80:436a
19. Ledwell JL, Aldrich RW (1999) Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J Gen Physiol 113:389-414
20. + channel activation. Biophys J 81:905-916
21. Mannuzzu LM, Moronne MM, Isacoff EY (1996) Direct physical measure of conformational rearrangement underlying potassium channel gating. Science 271:213-216
22. Marten I, Hoshi T (1998) The N-terminus of the K channel KAT1 controls its voltage-dependent gating by altering the membrane electric field. Biophys J 74:2953-2962
23. + channel by three amino acid substitutions. Neuron 16:853-858
24. Papazian DM (1999) Potassium channels: some assembly required. Neuron 23:7-10
25. 2 terminus of Kv2.1 to channel activation. Am J Physiol 273:C1849-C1858
26. Ramaswami M, Gautam M, Kamb A, Rudy B, Tanouye MA, Mathew MK (1990) Human potassium channel genes: molecular cloning and functional expression. Mol Cell Neurosci 1:214-223
27. Sanguinetti MC, Xu QP (1999) Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J Physiol (Lond) 514:667-675
28. Schoppa NE, Sigworth FJ (1998) Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J Gen Physiol 111:313-342
29. + channels. Biochemistry 35:12133- 12140
30. + channel subunit proteins. Neuron 14:625-633
31. Smith PL, Baukrowitz T, Yellen G (1996) The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379:833-836
32. + channel. J Gen Physiol 117:469-490
33. + channels. Proc R Soc Lond Ser B 245:101-107
34. Stuhmer W, Conti F, Suzuki H, Wang XD, Noda M, Yahagi N, Kubo H, Numa S (1989) Structural parts involved in activation and inactivation of the sodium channel. Nature 339:597-603
35. Terlau H, Heinemann SH, Stuhmer W, Pongs O, Ludwig J (1997) Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment. J Physiol (Lond) 502:537-543
36. + channel inactivation domain. Biophys J 69:2415-2418
37. + channel. J Gen Physiol 102:1057-1083
38. + channel function by deletions at the N- and C-termini. Neuron 5:433-443
39. + channels. Neuroreport 11:2913-2917
40. Varshney A, Kavitha S, Mathew MK (2002) Modulation of voltage sensitivity by N-terminal cytoplasmic residues in human Kv1.2 channels. Eur Biophys J 31:365-372
41. + channel gating. Biophys J 79:231-246
42. + channels. J Gen Physiol 115:749-758
43. Yellen G (1998) The moving parts of voltage-gated ion channels. Q Rev Biophys 31:239-295
44. Zagotta WN, Hoshi T, Aldrich RW (1990) Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science 250:568-571
45. Zhou M, Morais-Cabral JH, Mann S, MacKinnon R (2001) Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411:657-661