The specificity of retinoid-induced irritation and its role in clinical efficacy

Exogenous Dermatology

Volumn 1, Issue 2, 2002, Pages 68-73

  MacGregor, Jennifer L ^a   Maibach, Howard I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Retinoic acid; Retinoid dermatitis; Sodium lauryl sulfate; Tretinoin

Indexed keywords

DODECYL SULFATE SODIUM; RETINOIC ACID; RETINOID;

ACNE VULGARIS; BURNING SENSATION; DERMATITIS; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG MECHANISM; DRY SKIN; ERYTHEMA; HISTOPATHOLOGY; HUMAN; PRIORITY JOURNAL; PRURITUS; QUANTITATIVE ANALYSIS; REVIEW; SKIN IRRITATION; SKIN MANIFESTATION; STRATUM CORNEUM; SUN EXPOSURE; WATER CONTENT; WATER LOSS;

EID: 0038513723     PISSN: 14244616     EISSN: None     Source Type: Journal    
DOI: 10.1159/000058335     Document Type: Review

References (47)

1. Webster GF, Berson D, Stein LF, et al: Efficacy and tolerability of once-daily tazarotene 0.1% gel versus once-daily tretinoin 0.25% gel in the treatment of facial acne vulgaris: A randomized trial. Cutis 2001;67:(suppl):4-9.
2. Leyden JJ, Lowe N, Kakita L, Draelos Z: Comparison of treatment of acne vulgaris with alternate-day applications of tazarotene 0.1% gel and once-daily applications of adapalene 0.1% gel: A randomized trial. Cutis 2001;67(suppl):10-16.
3. Leyden JJ, Grove GL: Randomized facial tolerability studies comparing gel formulations of retinoids used to treat acne vulgaris. Cutis 2001;67(suppl):17-27.
4. Leyden JJ: Treatment of photodamaged skin with topical tretinoin: An update. Plast Reconstr Surg 1998;102:1672-1675.
5. Bershad S, Poulin YP, Berson DS, et at: Topical retinoids in the treatment of acne vulgaris. Cutis 1999;64(suppl)8-20.
6. Denig NI, Hoke AW, Maibach HI: Irritant contact dermatitis. Postgrad Med 1998;103:199-213.
7. Appa Y: Retinoid therapy: Compatible skin care. Skin Pharmacol Appl Skin Physiol 1999;12:111-119.
8. Olsen EA, Katz HI, Levine N, et al: Tretinoin emollient cream for photodamaged skin: Results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol 1997;37(2, pt 1):217-226.
9. Leyden JJ: Topical treatment of acne vulgaris: Retinoids and cutaneous irritation. J Am Acad Dermatol 1998;38:S1-4.
10. Quigley JW, Bucks DAW: Reduced skin irritation with tretinoin containing polyolprepolymer-2, a new topical tretinoin delivery system: A summary of preclinical and clinical investigations. J Am Acad Dermatol 1998;38:S5-S10.
11. Griffiths CE, Kang S, Ellis CN, et al: Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: A double-blind, vehicle-controlled comparison of 0.1 and 0.025% tretinoin creams. Arch Dermatol 1995;131:1037-1044.
12. Fluhr JW, Vienne MP, Lauze C, et al: Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions. Dermatology 1999;199(suppl 1):57-60.
13. Kang S, Duell EA, Fisher GJ, et al: Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 1995;105:549-556.
14. Marks R, Hill S, Barton SP: The effects of an abrasive agent on normal skin and on photoaged skin in comparison with topical tretinoin. Br J Dermatol 1990;123:457-466.
15. Fisher GJ, Esmann J, Griffiths CEM, et al: Cellular, immunologic, and biochemical characterization of topical retinoic acid-treated human skin. J Invest Dermatol 1991;96:699-706.
16. Landecker A, Katayama MLS, Mammana AK, et al: Effects of retinoic and glycolic acids on neoangiogenesis and necrosis of axial dorsal skin flaps in rats. Aesth Plast Surg 2001;25:134-139
17. Effendy I, Weltfriend S, Patil S, Maibach HI: Differential irritant skin responses to topical retinoic acid and sodium lauryl sulphate: Alone and in crossover design. Br J Dermatol 1996;134:424-430.
18. Ale SI, Laugier JPK, Maibach HI: Differential irritant skin responses to tandem application of topical retinoic acid and sodium lauryl sulphate. II. Effect of time between first and second exposure. Br J Dermatol 1997;137:226-233.
19. Effendy I, Kwangsukstith C, Lee JY, Maibach HI: Functional changes in human stratum corneum induced by topical glycolic acid: Comparison with all-trans-retinoic acid. Acta Derm Venereol 1995;75:455-458.
20. Kligman LH, Sapadin AN, Schwartz E: Peeling agents and irritants, unlike tretinoin, do not stimulate collagen synthesis in the photoaged hairless mouse. Arch Dermatol Res 1996;288:615-620.
21. Griffiths CEM, Russman AN, Majmudar G, et al: Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med 1993;329:530-535.
22. Woodley DJ, Zelickson AS, Briggaman RA, et al: Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils: A preliminary report. JAMA 1990;263:3057-3059.
23. Watson REB, Craven NM, Kang S, et al: A short-term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents. J Invest Dermatol 2001;116:672-678.
24. Chen S, Ostrowski J, Whiting G, et al: Retinoic acid receptor gamma mediates topical retinoid efficacy and irritation in animal models. J Invest Dermatol 1995;104:779-783.
25. Fisher GJ, Voorhees JJ: Molecular mechanisms of retinoid actions in the skin. FASEB J 1996;10:1002-1013.
26. Feng X, Peng ZH, Di W, et al: Suprabasal expression of a dominant-negative RXR-α mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids. Genes Dev 1997;11:59-71.
27. Thacher SM, Standeven AM, Athanikar J, et al: Receptor specificity of retinoid-induced epidermal hyperplasia: Effect of RXR-selective agonists and correlation with topical irritation. J Pharmacol Exp Ther 1997;282:528-534.
28. Standeven AM, Teng M, Chandraratna RAS: Lack of involvement of retinoic acid receptor α in retinoid-induced skin irritation in hairless mice. Toxicol Lett 1997;92:231-240.
29. Vuligonda V, Lin Y, Thacher SM, et al: A new class of RAR subtype selective retinoids: Correlation of pharmacological effects with receptor activity. Bioorg Med Chem 1999;7:263-270.
30. Kang S, Voorhees JJ: Photoaging therapy with topical tretinoin: An evidence-based analysis. J Am Acad Dermatol 1998;39:S56-S61.
31. Thorne EG, Lufrano L, Boateng F, Sampson AR: Effect of tretinoin emollient cream on photodamaged skin: Relationship between clinical improvement and skin irritation. Br J Dermatol 1996;134:655-656.
32. Varani J, Inman DR, Perone P, et al: Retinoid toxicity for fibroblasts and epithelial cells is separable from growth promoting activity. J Invest Dermatol 1993;101:839-842.
33. Varani J, Fligiel SEG, Perone P, et al: Effects of sodium lauryl sulfate on human skin in organ culture: Comparison with all-trans-retinoic acid and epidermal growth factor. Dermatology 1993;187:19-25.
34. Elder JT, Cromie MA, Griffiths CEM, et al: Stimulus-selective induction of CRABP-II mRNA: A marker for retinoic acid action in human skin. J Invest Dermatol 1993;100:356-359.
35. Zouboulis CC, Voorhees JJ, Orfanos CE, Tavakkol A: Topical all-trans-retinoic acid (RA) induces an early, coordinated increase in RAinducible skin-specific gene/psoriasin and cellular RA-binding protein II mRNA levels which precedes skin erythema. Arch Dermatol Res 1996;288:664-669.
36. Fisher GJ, Talwar HS, Lin J, et al: Retinoic acid inhibits induction of c-jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest 1998;101:1432-1440.
37. Varani J, Warner RL, Gharaee-Kermani M, et al: Vitamin A antagonizes decreased cell growth and elevated collagen-degrading metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000;114:480-485.
38. Shalita AR: Clinical efficacy of topical retinoids in acne. Skin and Allergy News. Highlights Symp 25th Hawaii Dermatol Semin, Maui, Feb 7, 2001.
39. Verschoore M, Poncet M, Czernielewski J, et al: Adapalene 0.1% gel has low irritation potential. J Am Acad Dermatol 1997;36(6, pt 2):S103-S109.
40. Griffiths CEM, Ancian P, Humphries J, et al: Adapalene 0.1% gel and adapalene 0.1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers. Br J Dermatol 1998;139(suppl 52):12-16.
41. Galvin SA, Gilbert R, Baker M, et al: Comparative tolerance of adapalene gel and six different tretinoin formulations. Br J Dermatol 1998;139(suppl 52):34-40.
42. Clucas A, Verschoore M, Sorba V, et al: Adapalene 0.1% gel is better tolerated than tretinoin 0.025% gel in acne patients. J Am Acad Dermatol 1997;36(6, pt 2):S116-S118.
43. Alirezai M, Meynadier J, Jablonska S, et al: Comparative study of the efficacy and tolerability of 0.1 and 0.03 p.100 adapalene gel and 0.025 p.100 tretinoin gel in the treatment of acne. Ann Dermatol Vénéréol 1996;123:165-170.
44. Shalita A, Weiss JS, Chalker DK, et al: A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin 0.025% gel in the treatment of acne vulgaris: A multicenter trial. J Am Acad Dermatol 1996;34:482-485.
45. Cunliffe WJ, Poncet M, Loesche C, Verschoore M: A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: A meta-analysis of five randomized trials. Br J Dermatol 1998;139(suppl 52):48-56.
46. Griffiths CEM, Elder JT, Bernard BA, et al: Comparison of CD271 (adapalene) and alltrans-retinoic acid in human skin: Dissociation of epidermal effects and CRABP-II mRNA expression. J Invest Dermatol 1993;101:325-328.
47. Lee CH, Maibach HI: The sodium lauryl sulfate model: An overview. Contact Dermatitis 1995;33:1-7.