Adapalene 0-1% gel and adapalene 0-1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers

British Journal of Dermatology, Supplement

Volumn 139, Issue 52, 1998, Pages 12-16

  Griffiths, C E M ^a,b   Ancian, P ^a   Humphries, J ^a   Poncet, M ^a   Rizova, E ^a   Michel, S ^b   Clucas, A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GaWmiifl RandD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPALENE; RETINOIC ACID RECEPTOR;

ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; ERYTHEMA; GENETIC TRANSCRIPTION; HUMAN; IMAGE ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SKIN IRRITATION; TOPICAL DRUG ADMINISTRATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ERYTHEMA; GELS; HUMANS; KERATOLYTIC AGENTS; NAPHTHALENES; OINTMENTS; RECEPTORS, RETINOIC ACID; TRANSCRIPTION, GENETIC; TRETINOIN;

EID: 0031693960     PISSN: 0366077X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1998.1390s2012.x     Document Type: Article

References (8)

1. Shroot B, Michel S. Pharmacology and chemistry of adapalene. J Am Acad Dermatol 1997; 36: S96-103.
2. Verschoorc M, Poncet M, Czernielewski J ft al. Adapalene 0-1% gel has low skin irritation potential. J Am Acad Dermatol 1997: 36: S104-9.
3. Clucas A, Verschoore M, Sorba V, Poncet M, Baker M. Czernielewski J. Adapalene 0-1% gel is better tolerated than tretinoin in acne patients. J Am Acad Dermatol 1997; 36: S104-9.
4. Shalita A, Weiss JS, Chalker DK et al. A comparison of the efficacy and safety of adapalene gel 0-1% and tretinoin gel 0-025% in the treatment of acne vulgaris: a multicenter trial. J Am Acad Dermatol 1996: 34: 482-5.
5. Elder JT, Cromie MA, Griffiths CEM et al Stimulus-selective induction of CRABP II mRNA. A marker for retinoic acid action in human skin. J Invest Dermatol 1993; 100: 356-9.
6. Griffiths CEM, Finkel LJ, Tranfalgia MG et al. An i;i vivo experimental model for effects of topical retinoic acid in human skin. Br] Dermatol 1993; 129: 389-94.
7. Griffiths CEM, Elder JT, Bernard BA et al Comparison of CD271 (adapalene) and all-frans-retinoic acid in human skin: dissociation of epidermal effects and CRABP II mRNA expression. J Invest Dermatol 1993; 101: 325-8.
8. Loesche C, Tuley M. Dupre S. Studies of Cutaneous tolerance with adapalene cream, 0-1%. Poster N° 13 presented at 58th Annual Meeting of the American Acadamy of Dermatology, Orlando, February 26lh-March 4th 1998.