Adapalene 0.1% gel has low skin-irritation potential

Journal of the American Academy of Dermatology

Volumn 36, Issue 6 II SUPPL., 1997, Pages

  Verschoore, M ^a   Poncet, M ^a   Czernielewski, J ^a   Sorba, V ^a   Clucas, A ^a  

^a NONE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPALENE; RETINOIC ACID;

ACNE VULGARIS; ADULT; ARTICLE; BINDING SITE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN IRRITATION; WATER LOSS;

EID: 0030905887     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0190-9622(97)70051-3     Document Type: Article

References (8)

1. L Philips M Steinberg HI Maibach A comparison of rabbit and human skin responses to certain irritants Toxicol Appl Pharmacol 21 1972 369 392
2. JH Draize G Woodward HO Calvery Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes J Pharmacol Exp Ther 82 1944 377 419
3. CEM Griffiths JT Elder BA Bernard Comparison of CD271 (adapalene) and all-trans-retinoic acid in human skin: dissociation of epidermal effects and CRABP II nRNA expression J Invest Dermatol 101 1993 325 328
4. WJ Cunliffe R Caputo B Dreno Comparison of clinical safety and efficacy of adapalene gel and tretinoin gel in the treatment of acne vulgaris J Eur Acad Dermatol Venereol 5 suppl. 1 1995 S152 Poster 139
5. A Shalita JS Weiss DK Chalker A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: a multicenter trial J Am Acad Dermatol 34 1996 482 485
6. BA Bernard Adapalene, a new chemical entity with retinoid activity Skin Pharmacol 6 suppl. 1 1993 61 69
7. rd Annual AAD Meeting, New Orleans February 4-9 1995
8. CN Hensby D Cavey M Bouclier The in vivo and in vitro anti-inflammatory activity of CD271, a new retinoid-like modulator of cell differentiation U Reichert B Shroot Pharmacology and the skin: Pharmacology of retinoids in the skin vol 3 1989 Karger Basel 160 162