Kinetic determination of tight-binding impurities in enzyme inhibitors

Analytical Biochemistry

Volumn 319, Issue 2, 2003, Pages 272-279

  Kuzmic, Petr ^a   Hill, Craig ^b   Kirtley, Matthew P ^b   Janc, James W ^b  

^a BioKin Ltd   (United States)

^b CELERA   (United States)

Author keywords

Enzyme kinetics; Enzymes; Four parameter logistic equation; IC 50; Impurities; Inhibition constant; Inhibitor mixtures; Mast cell tryptase; Mathematics; Regression analysis; Statistics; Tight binding

Indexed keywords

CURVE FITTING; ENZYME KINETICS; ENZYMES; IMPURITIES; INTEGRAL EQUATIONS; INTELLIGENT SYSTEMS; KINETICS; LOGISTIC REGRESSION; MATHEMATICAL TECHNIQUES; MONTE CARLO METHODS; REGRESSION ANALYSIS; STATISTICS;

ANALYTICAL PROCEDURE; CONTAMINATED MATERIALS; INHIBITION CONSTANTS; KINETIC DETERMINATION; LOGISTIC EQUATIONS; MAST CELLS; MATHEMATICAL PROPERTIES; TIGHT BINDING;

ENZYME INHIBITION;

BENZAMIDINE; TRYPTASE; TRYPTASE INHIBITOR;

ARTICLE; COMPUTER PREDICTION; DRUG PROTEIN BINDING; ENZYME BINDING; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTERMETHOD COMPARISON; MAST CELL; MATHEMATICAL COMPUTING; MONTE CARLO METHOD; PRIORITY JOURNAL; REPRODUCIBILITY; STATISTICAL MODEL;

EID: 0038505726     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(03)00248-3     Document Type: Article

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