Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen

Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2001, Pages 1491-1508

  Adlington, R M ^b   Baldwin, J E ^b   Becker, G W ^c   Chen, B ^b   Cheng, L ^b   Cooper, S L ^b   Hermann, R B ^c   Howe, T J ^c   McCoull, W ^b   McNulty, A M ^c   Neubauer, B L ^c   Pritchard, G J ^a,b  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3' (BENZYLOXYCARBONYL)PHENYLACETATE] 4 BENZYL OXYCARBONYL 3 (4' HYDROXYBENZYL) 2 AZETIDINONE; 2 AZETIDINONE DERIVATIVE; 3 BENZYL 1 [3' (BENZYLOXYCARBONYL)PHENYLACETATE] 4 [4' (AMMONIUMMETHYL)BENZYLOXYCARBONYL] 2 AZETIDINONE; 3 BENZYL 1 ETHANESULFONYL 4 PHENYLCARBONYLOXYMETHYL 2 AZETIDINONE; 3 BENZYL 4 BENZYLOXYCARBONYL 1 [3' (BENZYLOXYCARBONYL)PHENYLACETATE] 2 AZETIDINONE; 4 BENZYLOXYCARBONYL 1 [3' (BENZYLOXYCARBONYL)PHENYLACETATE] 3 [4' HYDROXYBENZYL] 2 AZETIDINONE; ENZYME INHIBITOR; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTALLOGRAPHY; DRUG BINDING; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENERGY; ENZYME INHIBITION; HYDROPHOBICITY; IC 50; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL;

AZETIDINES; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; PROSTATE-SPECIFIC ANTIGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035837064     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000145g     Document Type: Article

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