Sequencing of the Pseudomonas aeruginosa and Burkholderia cepacia genomes and their applications in relation to cystic fibrosis

Journal of the Royal Society of Medicine, Supplement

Volumn 96, Issue 43, 2003, Pages 57-65

  Miller, Deborah A ^a   Mahenthiralingam, Eshwar ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL DNA; COMPLEMENTARY DNA; DNA FRAGMENT; GENOMIC DNA; PLASMID VECTOR;

ANTIBIOTIC THERAPY; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BURKHOLDERIA CEPACIA; COMPARATIVE GENOMIC HYBRIDIZATION; COMPUTER SYSTEM; CONFERENCE PAPER; CYSTIC FIBROSIS; DNA MICROARRAY; DNA SEQUENCE; GENBANK; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC VARIABILITY; GRAM NEGATIVE INFECTION; HAEMOPHILUS INFLUENZAE; HUMAN; MEDICAL RESEARCH; NONHUMAN; OPEN READING FRAME; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

BURKHOLDERIA CEPACIA; BURKHOLDERIA INFECTIONS; CYSTIC FIBROSIS; DRUG DESIGN; GENOME, BACTERIAL; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESEARCH; RESPIRATORY TRACT INFECTIONS; SEQUENCE ANALYSIS, DNA;

EID: 0038502489     PISSN: 02675331     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. Govan JRW, Deretic V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 1996;60:539-74
2. Stover CK, Pham XQ, Erwin AL, et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature 2000;406:959-64
3. Jones AM, Webb AK, Govan JR, Hart CA, Walshaw MJ. Pseudomonas aeruginosa cross-infection in cystic fibrosis. Lancet 2002;359:527-8
4. Mahenthiralingam E, Baldwin A, Vandamme P. Burkholderia cepacia complex infection in patients with cystic fibrosis. J Med Microbiol 2002;51:533-8
5. Coenye T, Vandamme P, Govan JR, LiPuma JJ. Taxonomy and identification of the Burkholderia cepacia complex. J Clin Microbiol 2001;39:3427-36
6. Vandamme P, Holmes B, Vancanneyt M, et al. Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients and proposal of Burkholderia multivorans sp. nov. Int J System Bacteriol 1997;47:1188-200
7. Mahenthiralingam E, Vandamme P, Campbell ME, et al. Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: virulent transmissible strains of genomovar III can replace Burkholderia multivorans. Clin Infect Dis 2001;33:1469-75
8. Fleischmann RD, Adams MD, White O, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 1995;269:496-512
9. Fraser CM, Eisen JA, Salzberg SL. Microbial genome sequencing. Nature 2000;406:799-803
10. Holloway BW. Genetic recombination in Pseudomonas aeruginosa. J Gen Microbiol 1955;13:572-81
11. Bentley SD, Chater KF, Cerdeno-Tarraga AM, et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 2002;417:141-7
12. Brinkman FS, Hancock RE, Stover CK. Sequencing solution: use volunteer annotators organized via Internet. Nature 2000;406:933
13. Govan JRW, Brown PH, Maddison J, et al. Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet 1993;342:15-19
14. Mahenthiralingam E, Coenye T, Chung JW, et al. Diagnostically and experimentally useful panel of strains from the Burkholderia cepacia complex. J Clin Microbiol 2000;38:910-13
15. Martin DW, Mohr CD. Invasion and intracellular survival of Burkholderia cepacia. Inject Immun 2000;68:24-9
16. Tomich M, Herfst CA, Golden JW, Mohr CD. Role of flagella in host cell invasion by Burkholderia cepacia. Infect Immun 2002;70:1799-806
17. Sokol PA, Darling P, Woods DE, Mahenthiralingam E, Kool C. Role of ornibactin biosynthesis in the virulence of Burkholderia cepacia: characterization of pvdA, the gene encoding L-ornithine N-5-oxygenase. Infect Immun 1999;67:4443-55
18. Lewenza S, Conway B, Greenberg EP, Sokol PA. Quorum Sensing in Burkholderia cepacia: identification of the LuxRI Homologs CepRL. J Bacteriol 1999;181:748-56
19. Mohr CD, Tomich M, Herfst CA. Cellular aspects of Burkholderia cepacia infection. Microbes Infect 2001;3:425-35
20. Parke JL, Gurian-Sherman D. Diversity of the Burkholderia cepacia complex and implications for risk assessment of biological control strains. Ann Rev Phytopathol 2001;39:225-58
21. Lessie TG, Hendrickson W, Manning BD, Devereux R. Genomic complexity and plasticity of Burkholderia cepacia. FEMS Microbiol Lett 1996;144:117-28
22. Roy-Burman A, Savel RH, Racine S, et al. Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis 2001;183:1767-74
23. Frank DW, Vallis A, Wiener-Kronish JP, et al. Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV. J Infect Dis 2002;186:64-73
24. Hensel M, Holden DW. Molecular genetic approaches for the study of virulence in both pathogenic bacteria and fungi. Microbiology 1996;142:1049-58
25. McGall GH, Christians FC. High-density genechip oligonucleotide probe arrays. Adv Biochem Engng Biotechnol 2002;77:21-42
26. Whiteley M, Bangera MG, Bumgarner RE, et al. Gene expression in Pseudomonas aeruginosa biofilms. Nature 2001;413:860-4
27. Liang X, Pham X-QT, Olson MV, Lory S. Identification of a genomic island present in the majority of pathogenic isolates of Pseudomonas aeruginosa. J Bacteriol 2001;183:843-53
28. Rosamond J, Allsop A. Harnessing the power of the genome in the search for new antibiotics. Science 2000;287:1973-6
29. Kline T, Andersen NH, Harwood EA, et al. Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC. J Med Chem 2002;45:3112-29