Cellular aspects of Burkholderia cepacia infection

Microbes and Infection

Volumn 3, Issue 5, 2001, Pages 425-435

  Mohr, Christian D ^a   Tomich, Mladen ^a   Herfst, Christine A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Burkholderia cepacia; Infection; Pathogenicity

Indexed keywords

BACTERIAL INFECTION; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BURKHOLDERIA CEPACIA; CELL INVASION; HOST CELL; HUMAN; IMMUNE RESPONSE; MUCOSA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SURVIVAL;

BURKHOLDERIA CEPACIA; BURKHOLDERIA INFECTIONS; EPITHELIAL CELLS; HUMANS; MACROPHAGES; MICROSCOPY, ELECTRON; OPPORTUNISTIC INFECTIONS; RESPIRATORY TRACT INFECTIONS; VIRULENCE;

BACTERIA (MICROORGANISMS); BURKHOLDERIA; BURKHOLDERIA CEPACIA; NEGIBACTERIA;

EID: 0035025618     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(01)01389-2     Document Type: Review

References (97)

1. Butler S.L., Doherty C.J., Hughes J.E., Nelson J.W., Govan J.R.W. Burkholderia cepacia and cystic fibrosis: do natural environments present a potential hazard? J. Clin. Microbiol. 40:1995;1001-1004.
2. Burkholder W.H. Sour skin: a bacterial rot of onion bulbs. Phytopathol. 60:1950;115-117.
3. Govan J.R.W., Deretic V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev. 45:1996;539-574.
4. Govan J.R.W., Hughes J.E., Vandamme P. Burkholderia cepacia: medical, taxonomic and ecological issues. J. Med. Microbiol. 104:1996;395-407.
5. Isles A., Maclusky I., Corey M., Gold R., Prober C., Fleming P., Levison H. Pseudomonas cepacia infection in cystic fibrosis: an emerging problem. J. Pediatr. 38:1984;206-210.
6. Mahenthiralingam E., Coenye T., Chung J.W., Speert D.P., Govan J.R.W., Taylor P., Vandamme P. Diagnostically and experimentally useful panel of strains from the Burkholderia cepacia complex. J. Clin. Microbiol. 47:2000;910-913.
7. Vandamme P., Holmes B., Vancanneyt M., Coenye T., Hoste B., Coopman R., Revets H., Lauwers S., Gillis M., Kersters K., Govan J.R.W. Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients and proposal of Burkholderia multivorans sp. nov. Int. J. Syst. Bacteriol. 51:1997;1188-1200.
8. Coenye T., LiPuma J.J., Henry D., Hoste B., Vandemeulebroucke K., Gillis M., Speert D.P., Vandamme P. Burkholderia cepacia genomovar VI, a new member of the Burkholderia cepacia complex isolated from cystic fibrosis patients. Int. J. Syst. Evol. Microbiol. 4:2001;271-279.
9. Holmes A., Govan J., Goldstein R. Agricultural use of Burkholderia cepacia: a threat to human health? Emerg. Infect. Dis. 144:1998;221-227.
10. Govan J.R.W., Vandamme P. Agricultural and medical microbiology: a time for bridging gaps. Microbiol. 5:1998;2373-2375.
11. LiPuma J.J., Mahenthiralingam E. Commercial use of Burkholderia cepacia. Emerg. Infect. Dis. 66:1999;305-306.
12. Govan J.R.W., Balendreau J., Vandamme P. Burkholderia cepacia - friend AND foe. ASM News. 123:2000;124-125.
13. Fisher M.C., LiPuma J.J., Dasen S.E., Caputo G.C., Mortensen J.E., McGowan K.L., Stull T.L. Source of Pseudomonas cepacia: ribotyping of isolates from patients and from the environment. J. Pediatr. 1:1993;745-747.
14. Hutchison M.L., Govan J.R.W. Pathogenicity of microbes associated with cystic fibrosis. Microbes Infect. 19:1999;1005-1014.
15. LiPuma J.J. Burkholderia cepacia management issues and new insights. Clin. Chest. M. 8:1998;473-486.
16. Nelson J.W., Butler S.L., Kreig D., Govan J.R.W. Virulence factors of Burkholderia cepacia. FEMS Immunol. Med. Microbiol. 256:1994;89-98.
17. Collins F.S. Cystic fibrosis: molecular biology and therapeutic implications. Science. 85:1992;774-779.
18. Smith J.J., Travis S.M., Greenberg E.P., Welsh M.J. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell. 95:1996;1-20.
19. Matsui H., Grubb B.R., Tarran R., Randell S.H., Gatzy J.T., Davis C.W., Boucher R.C. Evidence for perciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell. 44:1998;1005-1015.
20. Pitt T.L., Kaufmann M.E., Patel P.S., Benge L.C.A., Gaskin S., Livermore D.M. Type characterization and antibiotic susceptibility of Burkholderia (Pseudomonas) cepacia isolates from patients with cystic fibrosis in the United Kingdom and the Republic of Ireland. J. Med. Microbiol. 1996;203-210.
21. FitzSimmons S. National Cystic Fibrosis Patient Registry. Cystic Fibrosis Foundation Bethesda, MD. 108:1997.
22. O'Neil K.M., Herman J.H., Modlin J.F., Moxon E.R., Winkelstein J.A. Pseudomonas cepacia: an emerging pathogen in chronic granulomatous disease. J. Pediatr. 79:1986;940-942.
23. Winkelstein J.A., Marino M.C., Johnston R.B., Boyle J., Curnette J., Chanock S.J., Dickler H. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine. 170:2000;155-169.
24. Speert D., Bond M., Woodman R., Curnutte J. Infection with Pseudomonas cepacia in chronic granulomatous disease: role of nonoxidative killing by neutrophils in host defense. J. Infect. Dis. 19:1994;1524-1531.
25. Martino R., Gomez L., Pericas R., Salazar R., Sola C., Sierra J., Garau J. Bacteraemia caused by non-glucose-fermenting Gram negative bacilli and Aeromonas species in patients with haematological malignancies and solid tumours. Eur. J. Clin. Microbiol. Infect. Dis. 16:2000;320-323.
26. Pegues D.A., Carson L.A., Anderson R.L., Norgard M.J., Argent T.A., Jarvis W.R., Woernle C.H. Outbreak of Pseudomonas cepacia bacteremia in oncology patients. Clin. Infect. Dis. 29:1993;407-411.
27. Zinner S.H. Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria. Clin. Infect. Dis. 53:1999;490-494.
28. Ledson M.J., Gallagher M.J., Walshaw M.J. Chronic Burkholderia cepacia bronchiectasis in a non-cystic fibrosis individual. Thorax. 15:1998;430-432.
29. Pujul M., Corbella X., Carratala J., Gudiol F. Community acquired bacteremic Pseudomonas cepacia pneumonia in an immunocompetent host. Clin. Infect. Dis. 14:1992;887-888.
30. Hobson R., Gould I., Govan J. Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic otitis media. Eur. J. Clin. Microbiol. Infect. Dis. 2:1995;908-911.
31. Taplin D., Bassett D.C.J., Mertz P.M. Foot lesions associated with Pseudomonas cepacia. Lancet. 154:1971;568-571.
32. Verghese A., Al-Samman M., Nabhan D., Naylor A.D., Rivera M. Bacterial bronchitis and bronchiectasis in human immunodeficiency virus infection. Arch. Intern. M. 140:1994;2086-2091.
33. Beckman W., Lessie T.G. Response of Pseudomonas cepacia to ß-lactam antibiotics: utilization of penicillin G as the carbon source. J. Bacteriol. 161:1979;1126-1128.
34. Aaron S.D., Ferris W., Henry D.A., Speert D.P., MacDonald N.E. Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with Burkholderia cepacia. Am. J. Respir. Crit. Care M. 336:2000;1206-1212.
35. LiPuma J.J., Dasen S.E., Nielson D.W., Stern R.C., Stull T.L. Person-to-person transmission of Pseudomonas cepacia between patients with cystic fibrosis. Lancet. 1:1990;1094-1096.
36. Sun L., Jiang R.Z., Steinbach S., Holmes A., Campanelli C., Forstner J., Tan Y., Riley M., Goldstein R. The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain. Nat. M. 342:1995;661-666.
37. Govan J.R.W., Brown P.H., Maddison J., Doherty C.J., Nelson J.W., Dodd M., Greening A.P., Webb A.K. Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet. 176:1993;15-19.
38. Cheng H.P., Lessie T.G. Multiple replicons constituting the genome of Pseudomonas cepacia 17616. J. Bacteriol. 144:1994;4034-4042.
39. Lessie T.G., Hendrickson W., Manning B.D., Devereux R. Genomic complexity and plasticity of Burkholderia cepacia. FEMS Microbiol. Lett. 169:1996;117-128.
40. Scordilis G.E., Ree H., Lessie T.G. Identification of transposable elements which activate gene expression in Pseudomonas cepacia. J. Bacteriol. 66:1987;8-13.
41. Hutchison M.L., Poxton I.R., Govan J.R.W. Burkholderia cepacia produces a hemolysin that is capable of inducing apoptosis and degranulation of mammalian phagocytes. Infect. Immun. 57:1998;2033-2039.
42. McKevitt A.I., Bajaksouzian S., Klinger J.D., Woods D.E. Purification and characterization of an extracellular protease from Pseudomonas cepacia. Infect. Immun. 23:1989;771-778.
43. Lonon M.K., Morris-Hooke A. A nonhemolytic phospholipase C produced by Pseudomonas cepacia. Curr. Microbiol. 58:1991;139-142.
44. Vasil M.L., Krieg D.P., Kuhns J.S., Ogle J.W., Shortridge V.D., Ostroff R.M., Vasil A.I. Molecular analysis of hemolytic and phospholipase activities of Pseudomonas cepacia. Infect. Immun. 38:1990;4020-4029.
45. Weingardt C.L., Morris-Hooke A. A nonhemolytic phospholipase C from Burkholderia cepacia. Curr. Microbiol. 26:1999;233-238.
46. Lonon M.K., Woods D.E., Straus D.C. Production of lipase by clinical isolates of Pseudomonas cepacia. J. Clin. Microbiol. 67:1988;976-984.
47. 5-oxygenase. Infect. Immun. 135:1999;4443-4455.
48. Meyer J.M., Hohnadel D., Halle F. Cepabactin from Pseudomonas cepacia, a new type of siderophore. J. Gen. Microbiol. 8:1989;1479-1487.
49. Meyer J.M., Tran Van V., Stintzi A., Berge O., Winkelmann G. Ornibactin production and transport properties in strains of Burkholderia vietnamiensis and Burkholderia cepacia (formerly Pseudomonas cepacia). Biometals. 23:1995;309-317.
50. Sokol P.A. Production and utilization of pyochelin by clinical isolates of Pseudomonas cepacia. J. Clin. Microbiol. 36:1986;560-562.
51. Sokol P.A., Lewis C.J., Dennis J.J. Isolation of a novel siderophore from Pseudomonas cepacia. J. Med. Microbiol. 6:1992;184-189.
52. Stephan J., Freund S., Beck W., Jung G., Meyer J.M., Winkelmann G. Ornibactins-a new family of siderophores from Pseudomonas. Biometals. 139:1993;93-100.
53. Visca P., Ciervo A., Sanfilippo V., Orsi N. Iron-regulated salicylate synthesis by Pseudomonas spp. J. Gen. Microbiol. 66:1993;1995-2001.
54. Darling P., Chan M., Cox A.D., Sokol P.A. Siderophore production by cystic fibrosis isolates of Burkholderia cepacia. Infect. Immun. 11:1998;874-877.
55. Shaw D., Poxton I.R., Govan J.R.W. Biological activity of Burkholderia (Pseudomonas) cepacia lipopolysaccharide. FEMS Immunol. Med. Microbiol. 27:1995;99-106.
56. Hutchison M.L., Bonell E.C., Poxton I.R., Govan J.R.W. Endotoxic activity of lipopolysaccharides isolated from emergent potential cystic fibrosis pathogens. FEMS Immunol. Med. Microbiol. 65:2000;73-77.
57. Hughes J.E., Stewart J., Barclay G.R., Govan J.R.W. Priming of neutrophil respiratory burst activity by lipopolysaccharide from Burkholderia cepacia. Infect. Immun. 37:1997;4281-4287.
58. Straus D.C., Lonon M.K., Hutson J.C. Inhibition of rat alveolar macrophage phagocytic function by Pseudomonas cepacia lipase. J. Med. Microbiol. 67:1992;335-340.
59. Zughaier S.M., Ryley H.C., Jackson S.K. A melanin pigment purified from an epidemic strain of Burkholderia cepacia attenuates monocyte respiratory burst activity by scavenging superoxide anion. Infect. Immun. 35:1999;908-913.
60. Mahenthiralingam E., Simpson D.A., Speert D.P. Identification and characterization of a novel DNA marker associated with epidemic Burkholderia cepacia strains recovered from patients with cystic fibrosis. J. Clin. Microbiol. 181:1997;808-816.
61. Lewenza S., Conway B., Greenberg E.P., Sokol P.A. Quorum sensing in Burkholderia cepacia: identification of the LuxRI homologs CepRI. J. Bacteriol. 97:1999;748-756.
62. Greenberg E.P., Parsek M.R. Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc. Natl. Acad. Sci. 177:2000;8789-8793.
63. Dunny G.M, Winans S.C.E. Cell-Cell Signaling in Bacteria. 1999;ASM Press, Washington, D.C.
64. McKenney D., Brown K.E., Allison D.G. Influence of Pseudomonas aeruginosa exoproducts on virulence factor production in Burkholderia cepacia: evidence of interspecies communication. J. Bacteriol. 184:1995;6989-6992.
65. Geisenberger O., Givskov M., Riedel K., Hoiby N., Tummler B., Eberl L. Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis. FEMS Microbiol. Lett. 14:2000;273-278.
66. Hendry J., Elborn J.S., Nixon L., Shale D.J., Webb A.K. Cystic fibrosis: inflammatory response to infection with Burkholderia cepacia and Pseudomonas aeruginosa. Eur. Respir. J. 29:1999;435-438.
67. Hendry J., Nixon L., Dodd M., Elborn J.S., Govan J., Shale D.J., Webb A.K. Pulmonary function, serum markers of inflammation, and IgG antibodies to core lipopolysaccharide of Burkholderia cepacia in adults with cystic fibrosis, following colonization with Burkholderia cepacia. Pediatr. Pulmonol. 157:2000;8-10.
68. Aronoff S.C., Stern R.C. Serum IgG antibody to the outer membrane antigens of Pseudomonas cepacia and Pseudomonas aeruginosa in cystic fibrosis. J. Infect. Dis. 1:1988;934-940.
69. Aronoff S.C., Quiner F.J., Stern R.C. Longitudinal serum IgG response to Pseudomonas cepacia surface antigens in cystic fibrosis. Pediatr. Pulmonol. 22:1991;289-293.
70. Starke J.R., Morven E.S., Langston C., Baker C.J. A mouse model of chronic pulmonary infection with Pseudomonas aeruginosa and Pseudomonas cepacia. Ped. Res. 67:1987;698-702.
71. Speert D.P., Steen B., Halsey K., Kwan E. A murine model of infection with Burkholderia cepacia with sustained persistence in the spleen. Infect. Immun. 9:1999;4027-4032.
72. Davidson D.J., Dorin J.R., McLachlan G., Ranaldi V., Lamb D., Doherty C., Govan J., Porteous D.J. Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens. Nat. Genet. 260:1995;351-357.
73. Krivan H.C., Ginsburg V., Roberts D.D. Pseudomonas aeruginosa and Pseudomonas cepacia isolated from cystic fibrosis patients bind specifically to gangliotetraosylceramide (asialo GM1) and gangliotriaosylceramide (asialo GM2). Arch. Biochem. Biophys. 89:1988;493-496.
74. Sajjan U.S., Corey M., Karmali M.A., Forstner J.F. Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis. J. Clin. Invest. 60:1992;648-656.
75. Kuehn M., Lent K., Haas J., Hagenzieker J., Cervin M., Smith A.L. Fimbriation of Pseudomonas cepacia. Infect. Immun. 17:1992;2002-2007.
76. Cervin M.A., Simpson D.A., Smith A.L., Lory S. Differences in eucaryotic cell binding of Pseudomonas. Microb. Pathogen. 60:1994;291-299.
77. Sajjan S.U., Forstner J.F. Identification of the mucin-binding adhesin of Pseudomonas cepacia isolated from patients with cystic fibrosis. Infect. Immun. 61:1992;1434-1440.
78. Sajjan U.S., Forstner J.F. Role of a 22-kilodalton pilin protein in binding of Pseudomonas cepacia to buccal epithelial cells. Infect. Immun. 68:1993;3157-3163.
79. Sajjan U.S, Sylvester F.A., Forstner J.F. Cable-piliated Burkholderia cepacia binds to cytokeratin 13 of epithelial cells. Infect. Immun. 49:2000;1787-1795.
80. Sajjan U., Wu Y., Kent G., Forstner J. Preferential adherence of cable-piliated Burkholderia cepacia to respiratory epithelia of CF knockout mice and human cystic fibrosis lung explants. J. Med. Microbiol. 177:2000;875-885.
81. Sajjan U.S., Sun L., Goldstein R., Forstner J.F. Cable (Cbl) type II pili of cystic fibrosis-associated Burkholderia (Pseudomonas) cepacia: nucleotide sequence of the cblA major subunit pilin gene and novel morphology of the assembled appendage fibers. J. Bacteriol. 4:1995;1030-1038.
82. Gaastra W., Svennerholm A.M. Colonization factors of human enterotoxigenic Escherichia coli (ETEC). Trends Microbiol. 177:1996;444-452.
83. Goldstein R., Sun L., Jiang R.Z., Sajjan U., Forstner J.F., Campanelli C. Structurally variant classes of pilus appendage fibers coexpressed from Burkholderia (Pseudomonas) cepacia. J. Bacteriol. 38:1995;1039-1052.
84. Clode F.E., Kaufmann M.E., Malnick H., Pitt T.L. Distribution of genes encoding putative transmissibility factors among epidemic and nonepidemic strains of Burkholderia cepacia from cystic fibrosis patients in the United Kingdom. J. Clin. Microbiol. 58:2000;1763-1766.
85. Saiman L., Cacalano G., Prince A. Pseudomonas cepacia adherence to respiratory epithelial cells is enhanced by Pseudomonas aeruginosa. Infect. Immun. 64:1990;2578-2584.
86. Sylvester F.A., Sajjan U.S., Forstner J.F. Burkholderia (basonym Pseudomonas) cepacia binding to lipid receptors. Infect. Immun. 64:1996;1420-1425.
87. Burns J.L., Jonas M., Chi E.Y., Clark D.K., Berger A., Griffith A. Invasion of respiratory epithelial cells by Burkholderia (Pseudomonas) cepacia. Infect. Immun. 68:1996;4054-4059.
88. Martin D.W., Mohr C.D. Invasion and intracellular survival of Burkholderia cepacia. Infect. Immun. 4:2000;24-29.
89. Tipper J.L., Ingham E., Cove J.H., Todd N.J., Kerr K.G. Survival and multiplication of Burkholderia cepacia within respiratory epithelial cells. Clin. Microbiol. Infect. 39:1998;450-459.
90. Nelson J.W., Butler S.L., Brown P.H., Greening A.P., Govan J.R.W. Serum IgG and sputum IgA antibody to core lipopolysaccharide antigen from Pseudomonas cepacia in patients with cystic fibrosis. J. Med. Microbiol. 61:1993;39-47.
91. Finlay B., Falkow S. Common themes in microbial pathogenicity revisited. Microbiol. Mol. Biol. Rev. 145:1997;136-169.
92. Saini L.S., Galsworthy S.B., John M.A., Valvano M.A. Intracellular survival of Burkholderia cepacia complex isolates in the presence of macrophage cell activation. Microbiol. 145:1999;3465-3475.
93. Marolda C.L., Hauroder B., John M.A., Michel R., Valvano M.A. Intracellular survival and saprophytic growth of isolates from the Burkholderia cepacia complex in free-living amoebae. Microbiol. 19:1999;1509-1517.
94. Landers P., Kerr K.G., Rowbotham T.J., Tipper J.L., Keig P.M., Ingham E., Denton M. Survival and growth of Burkholderia cepacia within the free-living amoeba Acanthamoeba polyphaga. Eur. J. Clin. Microbiol. Infect. Dis. 62:2000;121-123.
95. Bianciotto V., Bandi C., Minerdi D., Sironi M., Tichy H.V., Bonfante P. An obligately endosymbiotic mycorrhizal fungus itself harbors obligately intracellular bacteria. Appl. Environ. Microbiol. 66:1996;3005-3010.
96. Bianciotto V., Lumini E., Lanfranco L., Minerdi D., Bonfante P., Perotto S. Detection and identification of bacterial endosymbionts in arbuscular mycorrhizal fungi belonging to the family Gigasporaceae. Appl. Environ. Microbiol. 65:2000;4503-4509.
97. Gao L.Y., Harb O.S., Abu Kwaik Y. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionary distant host cells, mammalian macrophages and protozoa. Infect. Immun. 1997;4738-4746.