Role of mitochondrial KATP channels and protein kinase c in ischaemic preconditioning

Clinical and Experimental Pharmacology and Physiology

Volumn 30, Issue 5-6, 2003, Pages 426-436

  Uchiyama, Yuka ^a   Otani, Hajime ^a   Wakeno, Mayu ^a   Okada, Takayuki ^a   Uchiyama, Takamichi ^a   Sumida, Tomohiko ^a   Kido, Masakuni ^a   Imamura, Hiroji ^a   Nakao, Shinichi ^a   Shingu, Koh ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Ischaemic preconditioning; Mitochondrial KATP channels; Protein kinase C

Indexed keywords

5 HYDROXYDECANOIC ACID; CHELERYTHRINE; DIAZOXIDE; FLAVOPROTEIN; POTASSIUM CHANNEL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RO 318425; UNCLASSIFIED DRUG; CARRIER PROTEIN; ION CHANNEL; MEMBRANE PROTEIN; MITOCHONDRIAL K(ATP) CHANNEL; PROTEIN KINASE MODULATOR; SIGNAL PEPTIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; MITOCHONDRIAL POTASSIUM ADENOSINE TRIPHOSPHATE CHANNEL; MITOCHONDRION; NONHUMAN; RAT; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; METHODOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CARRIER PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ION CHANNELS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MEMBRANE PROTEINS; MYOCARDIAL ISCHEMIA; POTASSIUM CHANNELS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 0038471241     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2003.03853.x     Document Type: Article

References (27)

1. ATP channel. Annu. Rev. Physiol. 2000; 62: 79-109.
2. ATP channel. Am. J. Physiol. 1997; 273: H847-53.
3. 2+ overload injury in rat myocardium. Circ. Res. 1999; 84: 1156-65.
4. ATP channels triggers the preconditioned state by generating free radicals. Circ. Res. 2000; 87: 460-6.
5. ATP channel opening is important during index ischemia and following myocardial reperfusion in ischemic preconditioned rat hearts. J. Mol. Cell. Cardiol. 2001; 33: 831-4.
6. ATP channels in diazoxide-mediated protection in isolated rabbit hearts. Am. J. Physiol. Heart Circ. Physiol. 2001; 280: H246-55.
7. + channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circ. Res. 1999; 85: 731-41.
8. Liu Y, Sato T, O'Rourke B et al. Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection? Circulation 1998; 97: 2463-9.
9. + channels by protein kinase C. Circ. Res. 1998; 83: 110-14.
10. ATP in the heart: What happens, and what does not happen. Basic Res. Cardiol. 2000; 95: 275-9.
11. + channels modulate cardiac mitochondrial function. Am. J. Physiol. 1998; 275: H1567-76.
12. ATP channel opener diazoxide protects cardiac myocytes during metabolic inhibition without causing mitochondrial depolarization or flavoprotein oxidation. Br. J. Pharmacol. 2001; 134: 535-42.
13. 2+ overload during simulated ischemia and reperfusion: Possible mechanism of cardioprotection. Circ. Res. 2001; 89: 891-8.
14. Lu K, Otani H, Yamamura T et al. Protein kinase C isoform-dependent myocardial protection by ischemic preconditioning and potassium cardioplegia. J. Thorac. Cardiovasc. Surg. 2001; 121: 137-48.
15. Ping P, Zhang J, Zheng YT et al. Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits. Circ. Res. 1999; 85: 542-50.
16. ATP channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning. Am. J. Physiol. Heart Circ. Physiol. 2002; 283: H440-7.
17. Albert CJ, Ford DA. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Am. J. Physiol. 1999; 276: H642-50.
18. Yoshida K, Kawamura S, Mizukami Y et al. Implication of protein kinase C-α, δ, and ε isoforms in ischemic preconditioning in perfused rat hearts. J. Biochem. 1997; 122: 506-11.
19. Chen C, Mochly-Rosen D. Opposing effects of delta and ε PKC in ethanol-induced cardioprotection. J. Mol. Cell. Cardiol. 2001; 33: 581-5.
20. Heidkamp MC, Bayer AL, Martin JL et al. Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C ε and δ in neonatal rat ventricular myocytes. Circ. Res. 2001; 89: 882-90.
21. Yamamoto S, Seta K, Morisco C et al. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J. Mol. Cell. Cardiol. 2001; 33: 1829-48.
22. + channel of heart mitochondria. Am. J. Physiol. Heart Circ. Physiol. 2001; 280: H649-57.
23. Halestrap AP. The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism. Biochim. Biophys. Acta 1989: 973: 355-82.
24. ATP channels. Am. J. Physiol. Heart Circ. Physiol. 2001; 280: H2321-8.
25. Vanden Hoek T, Becker LB, Shao ZH et al. Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ. Res. 2000; 86: 541-8.
26. Akao M, Ohler A, O'Rourke B et al. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ. Res. 2001; 88: 1267-75.
27. ATP channels. Circ. Res. 2001; 89: 273-8.