Neuropsychological performance of OCD patients before and after treatment with fluoxetine: Evidence for persistent cognitive deficits

Psychological Medicine

Volumn 33, Issue 5, 2003, Pages 917-925

  Nielen, M M A ^a   Den Boer, J A ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; FLUOXETINE; SEROTONIN;

ADULT; ARTICLE; ATTENTION; BRAIN DYSFUNCTION; BRAIN FUNCTION; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG USE; EVIDENCE BASED MEDICINE; FEMALE; HUMAN; MALE; MOTOR PERFORMANCE; NEUROPSYCHOLOGY; OBSESSIVE COMPULSIVE DISORDER; ORBITAL CORTEX; PATTERN RECOGNITION; PLANNING; PREFRONTAL CORTEX; PSYCHOLOGIC ASSESSMENT; SPATIAL MEMORY; STRIATE CORTEX; SYMPTOMATOLOGY; TASK PERFORMANCE; VOLUNTEER;

ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; COGNITION; FEMALE; FLUOXETINE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OBSESSIVE-COMPULSIVE DISORDER; PSYCHIATRIC STATUS RATING SCALES; TASK PERFORMANCE AND ANALYSIS; TREATMENT OUTCOME;

EID: 0038447102     PISSN: 00332917     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0033291703007682     Document Type: Article

References (46)

1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC.
2. Barnett, R., Maruff, P., Purcell, R., Wainwright, K., Kyrios, K., Brewer, W. & Pantelis, C. (1999). Impairment of olfactory identification in obsessive-compulsive disorder. Psychological Medicine 29, 1227-1233.
3. Baxter, L. R., Schwartz, J. M., Mazziotta, J. C. & Phelps, M. E. (1988). Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. American Journal of Psychiatry 145, 1560-1563.
4. Baxter, L. R. Jr., Schwartz, J. M., Bergman, K. S., Szuba, M. P., Guze, B. H., Mazziotta, J. C., Alazraki, A., Selin, C. E., Fern, H. K. & Phelps, M. (1992). Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Archives of General Psychiatry 49, 681-689.
5. Bechara, A., Damasio, A. R., Damasio, H. & Anderson, S. W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7-15.
6. Bolton, D., Raven, P., Madronal-Luque, R. & Marks, I. M. (2000). Neurological and neuropsychological signs in obsessive-compulsive disorder: interaction with behavioural treatment. Behaviour Research and Therapy 38, 695-708.
7. Boone, K. B., Anant, J., Philpott, L., Kaur, A. & Djenderedjian, A. (1991). Neuropsychological characteristics of nondepressed adults with obsessive-compulsive disorder. Neuropsychiatry Neuropsychology Behavioural Neurology 4, 96-109.
8. Cavedini, P., Riboldi, G., D'Unnucci, A., Belotti, P., Cisima, M. & Bellodi, L. (2002). Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia 40, 205-211.
9. Christensen, K. J., Kim, S. W., Dysken, M. W. & Hoover, K. M. (1992). Neuropsychological performance in obsessive-compulsive disorder. Biological Psychiatry 31, 4-18.
10. Dolan, M. & Park, I. (2002). The neuropsychology of antisocial personality disorder. Psychological Medicine 32, 417-427.
11. Downes, J. J., Roberts, A. C., Sahakian, B. J., Evenden, J. L., Robbins, R. G. & Robbins, T. W. (1989). Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction. Neuropsychologia 27, 1329-1343.
12. Elliott, R., Sahakian, B. J., Matthews, K., Bannerjea, A., Rimmer, J. & Robbins, T. W. (1997). Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology 131, 196-206.
13. Goodman, W. K., Price, L. H., Rasmussen, S. H., Mazure, C., Fleischmann, R. L., Hill, C. L., Heninger, G. R. & Charney, D. S. (1989). The Yale-Brown obsessive-compulsive scale: 1. Development, use, and reliability. Archives of General Psychiatry 46, 1006-1011.
14. Hamilton, M. (1960). Diagnosis and rating scale for depression. British Journal of Psychiatry 3, 76-78.
15. Head, D., Bolton, D. & Hymas, N. (1989). Deficit in cognitive shifting ability in patients with obsessive-compulsive disorder. Biological Psychiatry 25, 929-937.
16. Hermesh, H., Zohar, J., Weizman, A., Voet, H. & Gross-Isserof, R. (1999). Orbitofrontal cortex dysfunction in obsessive-compulsive disorder? II. Olfactory quality discrimination in obsessive-compulsive disorder. European Neuropsychopharmacology 9, 415-420.
17. Houx, P. J., Vreeling, F. W. & Jolles, J. (1993). Stroop interference effect: aging effects assessed with the Stroop Colour Word Test. Experimental Aging Research 19, 209-224.
18. Martinot, J. L., Allilaire, J. F., Mazoyer, B. M., Hantouche, E., Huret, J. D. & Legaut-Demare, F. (1990). Obsessive-compulsive disorder: a clinical, neuropsychological and positron emission tomography study. Acta Psychiatrica Scandinavia 82, 233-242.
19. Mataix-Cols, D., Alonso, P., Pifarre, J., Menchon, J. M. & Vallejo, J. (2002). Neuropsychological performance in medicated vs. unmedicated patients with obsessive-compulsive disorder. Psychiatry Research 109, 255-264.
20. Mehta, M. A., Swainson, R., Ogilvie, A. D., Sahakian, B. J. & Robbins, T. W. (2001). Improved short-term spatial memory but impaired reversal learning following the dopamine (d2) agonist bromicriptine in human volunteers. Psychopharmacology 159, 10-20.
21. Nie, N. H., Hadlai Hull, C., Jenkins, J. G., Steinbrenner, K. & Bent, D. H. (1986). SPSS, Statistical Package for the Social-Sciences (2nd edn.). McGraw-Hill: New York.
22. Nielen, M. M. A., Veltman, D. J., De Jong, R., Mulder, G. & Den Boer, J. A. (2002). Decision making performance in obsessive-compulsive disorder. Journal of Affective Disorders 69, 257-260.
23. O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J. & Andrews, C. (2001). Abstract reward and punishment representations in the human orbitofrontal cortex. Nature Neuroscience 4, 95-102.
24. Owen, A. M., Downes, J. J., Sahakian, B. J., Polkey, C. E. & Robbins, T. W. (1990). Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28, 1021-1034.
25. Owen, A. M., Doyon, J., Petrides, M. & Evans, A. C. (1996). Planning and working memory examined with positron emission tomography. European Journal of Neuroscience 8, 353-364.
26. Pantelis, C., Barnes, T. R. E., Nelson, H. E., Tanner, S., Weatherley, L., Owen, A. M. & Robbins, T. W. (1997). Frontalstriatal cognitive deficits in patients with chronic schizophrenia. Brain 120, 1823-1824.
27. Purcell, R., Maruff, P., Kyrios, M. & Pantelis, C. (1998a). Cognitive deficits in obsessive-compulsive disorder on tests for frontalstriatal function. Biological Psychiatry 43, 348-357.
28. Purcell, R., Maruff, P., Kyrios, M. & Pantelis, C. (1998b). Neuropsychological deficits in obsessive-compulsive disorder. Archives of General Psychiatry 55, 415-423.
29. Raven, J. (1960). Guide to the Standard Progressive Matrices, Sets A, B, C, D and E. Lewis: London.
30. Robbins, T. W., James, M., Owen, A. M., Sahakian, B. J., McInnes, L. & Rabbitt, P. (1994). Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia 5, 266-281.
31. Rogers, R. D., Owen, A. M., Middleton, H. C., Williams, E. J., Pickard, J. D., Sahakian, B. J. & Robbins, T. W. (1999a). Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. Journal of Neuroscience 20, 9029-9038.
32. Rogers, R. D., Blackshaw, A. J., Middleton, H. C., Matthews, K., Deakin, J. F. W., Sahakian, B. J. & Robbins, T. W. (1999b). Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour. Psychopharmacology 146, 482-491.
33. Rogers, R. D., Everitt, B. J., Badlacchino, A., Blackshaw, A. J., Swainson, R., Wynne, K., Baker, N. B., Hunger, J., Carthy, T., Booker, E., London, M., Deakin, J. F. W., Sahakian, B. J. & Robbins, T. W. (1999c). Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology 20, 322-339.
34. Rolls, E. T., Hornak, J., Wade, D. & McGrath, J. (1994). Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. Journal of Neurology, Neurosurgery and Psychiatry 57, 1518-1524.
35. Romano, S., Goodman, W., Tamura, R. & Gonzales, J. (2001). Long-term treatment of obsessive-compulsive disorder after comparison of fluoxetine versus placebo. Journal of Clinical Psychopharmacology 21, 46-52.
36. Sahakian, B. J., Morris, R. G., Evenden, J. L., Heald, A., Levy, R., Philpot, M. & Robbins, T. W. (1988). A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain 111, 695-718.
37. Sanz, M., Molina, V., Martin-Loeches, M., Calcedo, A. & Rubia, F. J. (2001). Auditory P300 event related potential and serotonin reuptake inhibitor treatment in obsessive-compulsive disorder. Psychiatry Research 101, 75-81.
38. Savage, C. R., Baer, L., Keuthen, N. J., Brown, H. D., Rauch, S. L. & Jenike, M. A. (1999). Organizational strategies mediate nonverbal memory impairment in obsessive-compulsive disorder. Biological Psychiatry 45, 905-916.
39. Saxena, S., Brody, A. L., Schwartz, J. M. & Baxter, L. R. (1998). Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. British Journal of Psychiatry (Suppl.) 35, 26-37.
40. Saxena, S., Brody, A. L., Maidment, K. M., Dunkin, J. J., Colgan, M., M., Alborzian, S., Phelps, M. E. & Baxter, L. R. Jr. (1999). Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology 21, 683-693.
41. Schmidtke, K., Schorb, A., Winkelmann, G. & Hohagen, F. (1998). Cognitive frontal lobe dysfunction in obsessive-compulsive disorder. Biological Psychiatry 43, 666-673.
42. Stroop, J. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology 18, 643-661.
43. Swedo, S. E., Schapiro, M. B., Grady, C. L. & Cheslow, D. L. (1989). Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Archives of General Psychiatry 46, 518-523.
44. Tollefson, G. D., Rampey, A. H., Potvin, J. H., Jenike, M. A., Rush, A. J., Dominquez, R. A., Koran, L. M., Shear, M. K., Goodman, W. & Genduso, L. A. (1994). A multi-center investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder. Archives of General Psychiatry 51, 559-567.
45. Veale, D. M., Sahakian, B. J., Owen, A. M. & Marks, I. M. (1996). Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder. Psychological Medicine 26, 1261-1269.
46. Zielinski, C. M., Taylor, M. A. & Juzwin, K. R. (1991). Neuropsychological deficits in obsessive-compulsive disorder. Neuropsychiatry, Neuropsychology and Behavioural Neurology 4, 110-126.