Keratin 20 helps maintain intermediate filament organization in intestinal epithelia

Molecular Biology of the Cell

Volumn 14, Issue 7, 2003, Pages 2959-2971

  Zhou, Qin ^a,b   Toivola, Diana M ^a,b   Feng, Ningguo ^a,b   Greenberg, Harry B ^a,b   Franke, Werner W ^c   Bishr Omary, M ^a,b  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN; KERATIN 20; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DISRUPTION; CONTROLLED STUDY; CROSS BREEDING; EPIDERMIS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; INTERMEDIATE FILAMENT; INTESTINE EPITHELIUM; INTESTINE VILLUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SKIN DISEASE; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; HT29 CELLS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; INTERMEDIATE FILAMENTS; INTESTINAL MUCOSA; INTESTINES; KERATIN-20; KERATINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS; RECOMBINANT PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 0038446762     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-02-0059     Document Type: Article

References (37)

1. Abe, M., and Oshima, R.G. (1990). A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice. J. Cell Biol. 111, 1197-1206.
2. Anastasi, E., Ponte, E., Gradini, R., Bulotta, A., Sale, P., Tiberti, C., Okamoto, H., Dotta, F., and Mario, U.D. (1999). Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes. Eur. J. Endocrinol. 141, 644-652.
3. Bader, B.L., and Franke, W.W. (1990). Cell type-specific and efficient synthesis of human cytokeratin 19 in transgenic mice. Differentiation 45, 109-118.
4. Bouwens, L. (1998). Cytokeratins and cell differentiation in the pancreas. J. Pathol. 184, 234-239.
5. Calnek, D., and Quaroni, A. (1993). Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation. Differentiation 53, 95-104.
6. Chandler, J.S., Calnek, D., and Quaroni, A. (1993). Identification and characterization of rat intestinal keratins. Molecular cloning of cDNAs encoding cytokeratin 8, 19, and a new 49-KDa type I cytokeratin (cytokeratin 21) expressed by differentiated intestinal epithelial cells. J. Biol. Chem. 266, 11932-11938.
7. Chou, C.F., Riopel, C.L., Rott, L.S., and Omary, M.B. (1993). A significant soluble keratin fraction in "simple epithelial cells: lack of an apparent phosphorylation and glycosylation role in keratin solubility. J. Cell Sci. 105, 433-445.
8. Coulombe, P.A., Hutton, M.E., Letai, A., Hebert, A., Paller, A.S., and Fuchs, E. (1991). Point mutations in human14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell 66, 1301-1311.
9. Coulombe, P.A., and Omary, M.B. (2002). "Hard" and "soft" principles defining the structure, function and regulation of keratin intermediate filaments. Curr. Opin. Cell Biol. 14, 110-122.
10. Fuchs, E., and Coulombe, P.A. (1992). Of mice and men: genetic skin diseases of keratin. Cell 69, 899-902.
11. Fuchs, E., and Weber, K. (1994). Intermediate filaments: structure, dynamics, function and disease. Annu. Rev. Genet. 63, 345-382.
12. Fuchs, E., and Cleveland, D.W. (1998). A structural scaffolding of intermediate filaments in health and disease. Science 279, 514-519.
13. Franke, W.W., Mahmood, N., Appelhans, B., Schmid, E., Freudenstein, C., Osborn, M., and Weber, K. (1979). The organization of cytokeratin filaments in the intestinal epithelium. Eur. J. Cell Biol. 19, 255-268.
14. Harnden, P., Mahmood, N., and Southgate, J. (1999). Expression of cytokeratin 20 redefines urothelial papillomas of the bladder. The Lancet 353, 974-977.
15. Herrmann, H., and Aebi, U. (2000). Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics. Curr. Opin. Cell Biol. 12, 79-90.
16. Hofmann, I., and Franke, W.W. (1997). Heterotypic interactions and filament assembly of type I and type II cytokeratins in vitro: viscometry and determination of relative affinities. Eur. J. Cell Biol. 72, 122-132.
17. Ku, N.-O., Gish, R., Wright, T.L., and Omary, M.B. (2001). Keratin 8 mutations in patients with cryptogenic liver disease. N. Engl. J. Med. 344, 1580-1587.
18. Ku, N.-O., Liao, J., and Omary, M.B. (1998). Phosphorylation of human keratin 18 serine-33 regulates binding to 14-3-3 proteins. EMBO J. 17, 1892-1906.
19. Ku, N.-O., Michie, S.A., Oshima, R.G., and Omary, M.B. (1995). Chronic hepatitis, hepatocyte fragility and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J. Cell Biol. 131, 1303-1314.
20. Ku, N.-O., Michie, S.A., Soetikno, R.M., Resurreccion, E.Z., Broome, R.L., Oshima, R.G., and Omary, M.B. (1996). Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin18 mutant. J. Clin. Investig. 98, 1034-1046.
21. Ku, N.-O., Wright, T.L., Terrault, N.A., Gish, R., and Omary, M.B. (1997). Mutation of human keratin 18 in association with cryptogenic cirrhosis. J. Clin. Investig. 99, 19-23.
22. Ku, N.-O., Zhou, X., Toivola, D.M., and Omary, M.B. (1999). The cytoskeleton of digestive epithelia in health and disease. Am. J. Physiol. 277, G1108-G1137.
23. Leech, S.N., Kolar, A.J., Barrett, P.D., Sinclair, S.A., and Leonard, N. (2001). Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1. J. Clin. Pathol. 54, 727-729.
24. Magin, T.M., Hesse, M., and Schroder, R. (2000). Novel insights into intermediate-filament function from studies of transgenic and knockout mice. Protoplasma 211, 140-150.
25. Moll, R., Franke, W.W., Schiller, D.L., Geiger, B., and Krepler, R. (1982). The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31, 11-24.
26. Moll, R., Lowe, A., Laufer, J., and Franke, W.W. (1992). Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am. J. Pathol. 140, 427-447.
27. Moll, R., Schiller, D., and Franke, W.W. (1990). Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J. Cell Biol. 111, 567-580.
28. Moll, R., Zimbelmann, R., Golsdchmidt, M., Keith, M., Laufer, J., Kasper, M., Koch, P., and Franke, W.W. (1993). The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. Differentiation 53, 75-93.
29. O'Guin, M., Galvin, S., Schermer, A., and Sun, T.-T. (1987). Pattern of keratin expression defines distinct pathways of epithelial development and differentiation. Curr. Top. Dev. Biol. 22, 97-125.
30. Omary, M.B., Ku, N.-O., and Toivola, D.M. (2002). Keratins: guardians of the liver. Hepatology 35, 251-257.
31. Oshima, R.G. (2002). Apoptosis and keratin intermediate filaments. Cell Death Differ. 9, 486-492.
32. Quaroni, A., Calnek, D., Quaroni, E., and Chandler, J.S. (1991). Keratin expression in rat intestinal crypt and villus cells. J. Biol. Chem. 266, 11923-11931.
33. Takemura, R., Masaki, T., and Hirokawa, N. (1988). Developmental organization of the intestinal brush-border cytoskeleton. Cell Motil. Cytoskeketon 9, 299-311.
34. Toivola, D.M., Omary, M.B., Ku, N.-O., Peltola, O., Baribault, H., and Eriksson, J.E. (1998). Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity. Hepatology 28, 116-128.
35. Toivola, D.M., Ku, N.-O., Ghori, N., Lowe, A.W., Michie, S.A., and Omary, M.B. (2000a). Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury. Exp. Cell Res. 255, 156-170.
36. Toivola, D.M., Baribault, H., Magin, T.M., Michie, S.A., and Omary, M.B. (2000b). Simple epithelial keratins are dispensable for cytoprotection in two pancreatitis models. Am. J. Physiol. 279, G1343-1354.
37. Wildi, S., Kleeff, J., Maruyama, H., Maurer, C.A., Friess, H., Buchler, M.W., Lander, A.D., and Korc, M. (1999). Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer. Clin. Cancer Res. 10, 2840-2847.