Acute exposure to the nutritional toxin alcohol reduces brain protein synthesis in vivo

Metabolism: Clinical and Experimental

Volumn 52, Issue 4, 2003, Pages 389-396

  Bonner, A B ^a,b,c   Dalwai, S ^a,b,c   Marway, J S ^a,b,c   Preedy, V R ^a,b,c  

^a UNIVERSITY OF KENT   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE INHIBITOR; CYANAMIDE; NEUROTOXIN; PHENYLALANINE; SODIUM CHLORIDE; TOXIN; TRITIUM; ALDEHYDE DEHYDROGENASE; CENTRAL DEPRESSANT AGENT; ENZYME INHIBITOR; NERVE PROTEIN;

ALCOHOLIC BEVERAGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN INJURY; BRAIN REGION; BRAIN STEM; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; EXPOSURE; IN VIVO STUDY; MALE; MESENCEPHALON; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS REGULATION; RADIOSENSITIVITY; RAT; TISSUE SPECIFICITY; ANIMAL; BIOSYNTHESIS; BRAIN LEVEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG TOLERANCE; KINETICS; METABOLISM; WISTAR RAT;

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; ANIMALS; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYANAMIDE; DRUG TOLERANCE; ENZYME INHIBITORS; ETHANOL; KINETICS; MALE; NERVE TISSUE PROTEINS; PHENYLALANINE; RATS; RATS, WISTAR;

EID: 0038413738     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2003.50009     Document Type: Article

References (67)

1. Maezawa Y, Yamauchi M, Searashi Y, et al: Association of restriction fragment-length polymorphisms in the alcohol dehydrogenase 2 gene with alcoholic brain atrophy. Alcohol Clin Exp Res 20:29A-32A, 1996
2. Estruch R, Nicolas JM, Salamero M, et al: Atrophy of the corpus callosum in chronic alcoholism. J Neurol Sci 146:145-151, 1997
3. Preedy VR, Reilly ME, Patel VP, et al: Protein metabolism in alcoholism: Effects on specific tissues and the whole body. Nutrition 15:604-608, 1999
4. Tewari S, Winn D, Daly C, et al: Translational regulation in growing clonal human astrocytoma cells in culture. Neurochem Res 13:749-760, 1988
5. Goertz B: Effect of ethanol on rat brain protein synthesis. I. Acute administration. Exp Brain Res 48:438-442, 1982
6. Rawat AK: Nucleic acid and protein synthesis inhibition in developing brain by ethanol in the absence of hypothermia. Neurobehav Toxicol Teratol 7:161-166, 1985
7. Pennington S, Kalmus G: Brain growth during ethanol-induced hypoplasia. Drug Alcohol Depend 20:279-286, 1987
8. Ward LC, Tiernan JM, Fagan C: Ethanol and brain protein synthesis in the rat in vivo. Neurosci Lett 53:273-278, 1985
9. Ward LC, Tiernan JM, Hayling N, et al: Protein turnover in subcellular fractions of brain from the ethanol-fed rat. Neurosci Lett 7:353-357, 1987
10. Dunmire CR, La Velle FW: Effect of ethanol on nucleolar structure: A cytologic indication of change in RNA/protein synthesis. Anat Rec 206:363-371, 1983
11. Noble EP, Tewari S: Ethanol and brain ribosomes. Fed Proc 34:1942-1947, 1975
12. Peters JE, Steele WJ: Changes in in vivo rates of protein synthesis on free and membrane-bound polysomes in rat brain during the development of physical dependence on ethanol and after the withdrawal of ethanol. Brain Res 231:411-426, 1982
13. Reeds PJ, Davis TA: Of flux and flooding: The advantages and problems of different isotopic methods for quantifying protein turnover in vivo: I. Methods based on dilution of a tracer. Curr Opin Clin Nutr Metab Care 2:23-28, 1999
14. Davis TA, Reeds PJ: Of flux and flooding: The advantages and problems of different isotopic methods for quantifying protein turnover in vivo: II. Methods based on the incorporation of a tracer. Curr Opin Clin Nutr Metab Care 4:51-56, 2001
15. McNurlan MA, Tomkins AM, Garlick PJ: The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochem J 178:373-379, 1979
16. Williams LM, Ballmer PE, Hannah LT, et al: Changes in regional protein synthesis in rat brain and pituitary after systemic interleukin-1 beta administration. Am J Physiol 267:E915-E920, 1994
17. Dunlop DS, Yang XR, Lajtha A: The effect of elevated plasma phenylalanine levels on protein synthesis rates in adult rat brain. Biochem J 302:601-610, 1994
18. 3H]phenylalanine. Biochem J 192:719-723, 1980
19. Adachi J, Asano M, Ueno Y, et al: Acute effect of ethanol on 7-hydroperoxycholesterol in muscle and liver. Lipids 36:267-271, 2001
20. Garlick PJ, Millward DJ, James WP: The diurnal response of muscle and liver protein synthesis in vivo in meal-fed rats. Biochem J 136:935-945, 1973
21. Millward DJ, Garlick PJ, Stewart RJ, et al: Skeletal-muscle growth and protein turnover. Biochem J 150:235-243, 1975
22. Waterlow JC, Garlick PJ, Millward DJ: Protein Turnover in Mammalian Tissues and the Whole Body. North-Holland, Amsterdam, The Netherlands, 1978
23. McNurlan MA, Tomkins AM, Garlick PJ: The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochem J 178:373-379, 1979
24. Nayak P, Chatterjee AK: Impact of protein malnutrition on subcellular nucleic acid and protein status of brain of aluminum-exposed rats. J Toxicol Sci 23:1-14, 1998
25. Martinez B, Del Hoyo P, Martin MA, et al: Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats. J Neurochem 78:1054-1063, 2001
26. Owasoyo JO, Iramain CA: Effect of acute ethanol intoxication on the enzymes of the cholinergic system in mouse brain. Toxicol Lett 9:267-270, 1981
27. Chan AW, Heubusch PH: Relationship of brain cyclic nucleotide levels and the interaction of ethanol with chlordiazepoxide. Biochem Pharmacol 31:85-89, 1982
28. Leslie SW, Barr E, Chandler J, et al: Inhibition of fast- and slow-phase depolarization-dependent synaptosomal calcium uptake by ethanol. J Pharmacol Exp Ther 225:571-575, 1983
29. George SR, Fan T, Roldan L, et al: Corticotropin-releasing factor is altered in brains of animals with high preference for ethanol. Alcohol Clin Exp Res 14:425-429, 1990
30. Bonner AB, Marway JS, Swann M, et al: Brain nucleic acid composition and fractional rates of protein synthesis in response to chronic ethanol feeding: Comparison with skeletal muscle. Alcohol 13:581-587, 1996
31. Gotz ME, Janetzky B, Pohli S, et al: Chronic alcohol consumption and cerebral indices of oxidative stress: Is there a link? Alcohol Clin Exp Res 25:717-725, 2001
32. Harper C: The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 57:101-110, 1998
33. Harper CG, Kril JJ: Neuropathology of alcoholism. Alcohol Alcohol 25:207-216, 1990
34. Bark TH, McNurlan MA, Lang CH, et al: Increased protein synthesis after IGF-I or insulin infusion is localized to muscle in mice. Am J Physiol 275:E118-E123, 1998
35. Hashiguchi Y, Molina PE, Dorton S, et al: Central opiate mu-receptor-mediated suppression of tissue protein synthesis. Am J Physiol 273:R920-R927, 1997
36. Preedy VR, Paska L, Sugden PH, et al: The effects of surgical stress and short-term fasting on protein synthesis in vivo in diverse tissues of the mature rat. Biochem J 250:179-188, 1988
37. Preedy VR, Paska L, Sugden PH, et al: Protein synthesis in liver and extra-hepatic tissues after partial hepatectomy. Biochem J 267:325-330, 1990
38. Won CL, Oh YS: cAMP-induced stellation in primary astrocyte cultures with regional heterogeneity. Brain Res 887:250-258, 2000
39. Khan WA, Dechkovskaia AM, Herrick EA, et al: Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. Toxicol Sci 57:112-120, 2000
40. Satanovskaya VI: System of aldehyde metabolism in brain of rats during development of tolerance to the hypnotic effect of ethanol. Ann N Y Acad Sci 654:517-518, 1992
41. Bell RL, Stewart RB, Woods JE II, et al: Responsivity and development of tolerance to the motor impairing effects of moderate doses of ethanol in alcohol-preferring,P and -nonpreferring,NP rat lines. Alcohol Clin Exp Res 25:644-650, 2001
42. Crabbe JC: Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence. Alcohol Clin Exp Res 25:288-292, 2001
43. Pratt OE, Rooprai HK, Shaw GK, et al: The genesis of alcoholic brain tissue injury. Alcohol Alcohol 25:217-230, 1990
44. McKinnon G, De Jersey J, Shanley B, et al: The reaction of acetaldehyde with brain microtubular proteins: Formation of stable adducts and inhibition of polymerization. Neurosci Lett 79:163-168, 1987
45. West MW, Biggs TA, Tavares E, et al: Drinking patterns in genetic low-alcohol-drinking (LAD) rats after systemic cyanamide and cerebral injections of THP or 6-OHDA. Alcohol 15:239-247, 1998
46. Messiha FS: Strain dependent effects of ethanol on mouse brain and liver alcohol- and aldehyde-dehydrogenase. Neurobehav Toxicol Teratol 7:189-192, 1985
47. Rideout JM, Lim CK, Peters TJ: Assay of blood acetaldehyde by HPLC with fluorescence detection of its 2-diphenylacetyl-1,3-indandi-one-1-azine derivative. Clin Chim Acta 161:29-35, 1986
48. Siddiq T, Richardson PJ, Mitchell WD: Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde. Cell Biochem Funct 11:45-54, 1993
49. Marway JS, Preedy VR: The acute effects of ethanol and acetaldehyde on the synthesis of mixed and contractile proteins of the jejunum. Alcohol Alcohol 30:211-217, 1995
50. Worrall S, Niemela O, Parkkila S, et al: Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: Preferential localisation in the sarcolemmal and sub-sarcolemmal region. Eur J Clin Invest 31:723-730, 2001
51. Niemela O: Aldehyde-protein adducts in the liver as a result of ethanol-induced oxidative stress. Front Biosci 4:D506-513, 1999
52. Lin RC, Lumeng L: Formation of the 37KD protein-acetaldehyde adduct in liver during alcohol treatment is dependent on alcohol dehydrogenase activity. Alcohol Clin Exp Res 14:766-770, 1990
53. Ribiere C, Hininger I, Saffar-Boccara C, et al: Mitochondrial respiratory activity and superoxide radical generation in the liver, brain and heart after chronic ethanol intake. Biochem Pharmacol 47:1827-1833, 1994
54. Lang CH, Wu D, Frost RA, et al: Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E. Am J Physiol 277:E805-E814, 1999
55. Gulati A, Srimal RC, Bhargava HN: Effect of varying concentration of ethanol on systemic hemodynamics and regional circulation. Alcohol 6:9-15, 1989
56. Nakahara T, Hirano M, Uchimura H, et al: Chronic alcohol feeding and its influence on c-Fos and HSP70 gene expression in different brain regions of male and females rats. Metabolism 51:1562-1568, 2002
57. Soliman KF, Gabriel NN: Brain cholinergic involvement in the rapid development of tolerance to the hypothermic action of ethanol. Gen Pharmacol 16:137-140, 1985
58. Adell A, Myers RD: Lesioning of midbrain raphe nuclei with 5,7-DHT fails to alter ethanol intake in the low alcohol drinking (LAD) rat. Neuropsychopharmacol Biol Psychiatry 20:473-481, 1996
59. Zeevalk GD, Bernard LP, Nicklas WJ: Role of oxidative stress and the glutathione system in loss of dopamine neurons due to impairment of energy metabolism. J Neurochem 70:1421-1430, 1998
60. McCown TJ, Frye GD, Breese GR: Evidence for site specific ethanol actions in the CNS. Alcohol Drug Res 6:423-429, 1985
61. Perkonigg A, Lieb R, Wittchen HU: Substance use, abuse and dependence in Germany. A review of selected epidemiological data. Eur Addict Res 4:8-17, 1998
62. Reilly ME, Mantle D, Richardson PJ, et al: Studies on the time-course of ethanol's acute effects on skeletal muscle protein synthesis: Comparison with acute changes in proteolytic activity. Alcohol Clin Exp Res 21:792-798, 1997
63. Keiding S, Christensen NJ, Damgaard SE, et al: Ethanol metabolism in heavy drinkers after massive and moderate alcohol intake. Biochem Pharmacol 32:3097-3102, 1983
64. Cox DE, Sadler DW, Pounder DJ: Alcohol estimation at necropsy: Epidemiology, economics, and the elderly. Clin Pathol 50:197-201, 1997
65. Pauly T, Dahmen N, Szegedi A, et al: Blood ethanol levels and adenylyl cyclase activity in lymphocytes of alcoholic patients. Biol Psychiatry 45:489-493, 1999
66. Preedy VR, McIntosh A, Bonner AB, et al: Ethanol dosage regimens in studies of ethanol toxicity: Influence of nutrition and surgical interventions. Addict Biol 1:255-262, 1996
67. Amir I, Anwar N, Baraona E, et al: Ranitidine increases the bioavailability of imbibed alcohol by accelerating gastric emptying. Life Sci 58:511-518, 1996