Antiproliferative activity and mechanism of action of DZ-3358, a novel pyrimidinyl pyrazole derivative

Anticancer Research

Volumn 20, Issue 2 A, 2000, Pages 785-792

  Iwahana, Michio ^a   Ochi, Yusuke ^a   Ejima, Akio ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Anti tumor; Cancer cell; Fingerprint; Pyrimidinyl pyrazole; Tubulin inhibitor

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; DZ 3358; PYRAZOLE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; VINCRISTINE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CELL STRUCTURE; COLON CANCER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LEUKEMIA; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; STOMACH CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL CYCLE; CELL DIVISION; COLCHICINE; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; K562 CELLS; LEUKEMIA; LEUKEMIA P388; LUNG NEOPLASMS; MICE; MICROTUBULES; OVARIAN NEOPLASMS; PYRAZOLES; PYRIMIDINES; STOMACH NEOPLASMS; TUBULIN; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0034093594     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Boyd MR and Paull KD: Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Development Research 34: 91-109, 1995.
2. Naito H, Sugimori M, Mitsui I, Nakamura Y, Iwahana M, Ishi M, Hirotani K, Kumazawa E, and Ejima A: Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. Chem Pharm Bull 47: 1679-1684, 1999
3. Sato M, Arimoto M, Ueno K, Kojima H, Yamasaki T, Sakurai T, and Kasahara A: Psychotropic agents. 3. 4-(4-Substituted piperidinyl)-1-(4-fluorophenyl)-1-butanones with potent neuroleptic activity. J Med Chem 21: 1116-1120, 1978.
4. Paull KD, Lin CM, Malspeis L, and Hamel E: Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data. Cancer Res 52: 3892-3900, 1992.
5. Ines C, Leynadier D, Barasoain I, Peyrot V, Garcia P, Briand C, Rener GA, and Temple Jr C: Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863. Cancer Res 54: 75-84, 1994.
6. Hamel E: Natural products which interact with tubulin in the vinca domain: Maytansine, Rhizoxin, Phomopsin A, Dolastatins 10 and 15 and Halichondrin B. Pharmac Ther 55: 31-51, 1992.
7. Hamel E, Blokhin AV, Nagle DG, Yoo HD, and Gerwick WH: Limitations in the use of tubulin polymerization assays as a screen for the identification of new antimitotic agents: The potent marine natural product curacin A as an example. Drug Development Research 34: 110-120, 1995.
8. Panda D, Deluca K, Williams D, Jordan MA, and Wilson L: Antiproliferative mechanism of action of microtubule dynamics by high-affinity binding to microtubule ends. Proc Natl Acad Sci USA 95: 9313-9318, 1998.
9. Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, and Boyd MR: Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48: 589-601, 1988.
10. Crissman HA and Steinkamp JA: Rapid simultaneous measurement of DNA, protein and cell volume in single cells from large mammalian cell populations. J Cell Biol 59: 766-771, 1973.
11. Shelanski ML, Gaskin F, and Cantor CR: Microtubule assembly in the absence of added nucleotides. Proc Natl Acad Sci USA 70: 765-768, 1973.
12. Peyrot V, Briand C, and Andreu JM: C-terminal cleavage of tubulin by subtilisin enhances ring formation. Arch Biochem Biophys 249: 611-615, 1990.
13. Shiff PB, Fant J, and Horwitz SB: Promotion of microtubule assembly in vitro by taxol. Nature 277: 665-667, 1979.
14. Safiejko-Mroczka B and Bell PB Jr: Distribution of cytoskeletal proteins in neomycin-induced protrusions of human fibroblasts. Exp Cell Res 242: 495-514, 1998.