Induction of cell cycle-dependent cytotoxicity and apoptosis by new heterodinucleoside phosphate dimers of 5-fluorodeoxyuridine in PC-3 human prostate cancer cells

Biochemical Pharmacology

Volumn 60, Issue 12, 2000, Pages 1887-1896

  Cattaneo Pangrazzi, Rosanna M C ^a   Schott, Herbert ^b   Wunderli Allenspach, Heidi ^c   Derighetti, Michela ^a   Schwendener, Reto A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c ETH ZURICH   (Switzerland)

Author keywords

5 Fluorodeoxyuridine; Apoptosis; Cytotoxicity; Dimeric prodrugs; Prostate cancer; Thymidylate synthetase

Indexed keywords

2 DEOXY 5 FLUOROURIDYLYL (3'-5') 2' DEOXY 5 FLUORO N4 OCTADECYLCYTIDINE; CASPASE 3; DIMER; DNA FRAGMENT; FLOXURIDINE; FLOXURIDINE DERIVATIVE; N4 PALMITOYL 2' DEOXYCYTIDYLYL (3'-5') 5 FLUORO 2' DEOXYURIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PRODRUG; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE PHASE; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL NUCLEUS; CELL SIZE; DIMERIZATION; DINUCLEOSIDE PHOSPHATES; DRUG SCREENING ASSAYS, ANTITUMOR; FLOXURIDINE; HUMANS; MALE; OLIGODEOXYRIBONUCLEOTIDES; PRODRUGS; PROSTATIC NEOPLASMS; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0034672615     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00479-2     Document Type: Article

References (22)

1. Cancer statistics, 1994
2. Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer
3. Resistance to chemotherapeutic antimetabolites: A function of salvage pathway involvement and cellular response to DNA damage
4. Thymidylate synthase: A target for anticancer drug design
5. 4-octadecy lcytidine: A new amphiphilic dinucleoside phosphate
6. 4-hexadecyl-1-β-D-arabinofuranosylcytosine
7. Stabilization and the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its compositions
8. Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA
9. A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells
10. Inhibitory effects of the nucleoside analogue gemcitabine on prostatic carcinoma cells
11. Fenretinide: Induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells
12. Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3
13. Apoptosis and disease
14. Apoptosis in cancer therapy: Crossing the threshold
15. Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3
16. Cancer. A death in the life of p53
17. p53 is required for radiation-induced apoptosis in mouse thymocytes
18. Thymocyte apoptosis induced by p53-dependent and independent pathways
19. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
20. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
21. Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53
22. 4-octadecyl-1-β-D-arbinofuranosylcytosine in mice