FKBP12 mRNA expression is upregulated by intrinsic CNS neurons regenerating axons into peripheral nerve grafts in the brain

Experimental Neurology

Volumn 181, Issue 2, 2003, Pages 181-189

  Mason, M R J ^a   Lieberman, A R ^a   Latchman, D S ^b   Anderson, P N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Axonal regeneration; Cerebellum; FKBP12; Growth associated genes; Immunophilins; In situ hybridization; Thalamus

Indexed keywords

CHOLERA TOXIN B SUBUNIT; IMMUNOPHILIN; MESSENGER RNA; PROTEIN FKBP12; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL LABELING; CELL NUCLEUS; CELL STIMULATION; CELL TRANSPLANTATION; CENTRAL NERVOUS SYSTEM; CEREBELLUM NUCLEUS; FEMALE; IMMUNOHISTOCHEMISTRY; IMPLANTATION; IN SITU HYBRIDIZATION; MOLECULAR BIOLOGY; NERVE FIBER REGENERATION; NERVE GRAFT; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; RAT; RNA PROBE; SURVIVAL TIME; THALAMUS; TIBIAL NERVE; TISSUE SECTION; UPREGULATION;

EID: 0038392872     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4886(03)00038-4     Document Type: Article

References (44)

1. Anderson P.N., Campbell G., Zhang Y., Lieberman A.R. Cellular and molecular correlates of the regeneration of adult mammalian CNS axons into peripheral nerve grafts. Prog. Brain Res. 117:1998;211-232.
2. Anderson, P.N., Lieberman, A.R., 1999. Intrinsic determinants of differential axonal regeneration by adult mammalian CNS neurons, in: Saunders, N.R., Dziegielewska, K.M. (Eds.), Degeneration and regeneration in the nervous system, Harwood Academic Press, Amsterdam, pp. 53-75.
3. Bartsch S., Bartsch U., Dorries U., Faissner A., Weller A., Ekblom P., Schachner M. Expression of tenascin in the developing and adult cerebellar cortex. J. Neurosci. 12:1992;736-749.
4. Bavetta S., Hamlyn P.J., Burnstock G., Lieberman A.R., Anderson P.N. The effects of FK506 on dorsal column axons following spinal cord injury in adult rats neuroprotection and local regeneration . Exp. Neurol. 158:1999;382-393.
5. Benfey M., Bunger U.R., Vidal Sanz M., Bray G.M., Aguayo A.J. Axonal regeneration from GABAergic neurons in the adult rat thalamus. J. Neurocytol. 14:1985;279-296.
6. Berry M., Rees L., Hall S., Yiu P., Sievers J. Optic axons regenerate into sciatic nerve isografts only in the presence of Schwann cells. Brain Res. Bull. 20:1988;223-231.
7. Brillantes A.B., Ondrias K., Scott E., Kobrinsky E., Ondriasova E., Moschella M.C., Jayaraman T., Landers M., Ehrlich B.E., Marks A.R. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell. 77:1994;513-523.
8. Cameron A.M., Nucifora F.C. Jr., Fung E.T., Livingston D.J., Aldape R.A., Ross C.A., Snyder S.H. FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. J. Biol. Chem. 272:1997;27582-27588.
9. Cameron A.M., Steiner J.P., Sabatini D.M., Kaplin A.L., Walensky L.D., Snyder S.H. Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proc. Natl. Acad. Sci. USA. 92:1995;1784-1788.
10. Campbell G., Holt J.K.L., Shotton H.R., Anderson P.N., Bavetta S., Lieberman A.R. Spontaneous regeneration after optic nerve injury in adult rat. NeuroReport. 10:1999;3955-3960.
11. Carreau A., Gueugnon J., Benavides J., Vige X. Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons. Neuropharmacology. 36:1997;1755-1762.
12. Chaisuksunt V., Campbell G., Zhang Y., Schachner M., Lieberman A.R., Anderson P.N. The cell recognition molecule CHL1 is strongly upregulated by injured and regenerating thalamic neurons. J. Comp. Neurol. 425:2000;282-292.
13. Chaisuksunt V., Zhang Y., Anderson P.N., Campbell G., Vaudano E., Schachner M., Lieberman A.R. Patterns of expression and distribution of mRNAs for L1, CHL1, c-jun and GAP-43 in identified regenerating neurons of the cerebellum and brainstem of the adult rat. Neuroscience. 100:2000;87-108.
14. Chen Y.G., Liu F., Massague J. echanism of TGFbeta receptor inhibition by FKBP12. EMBO J. 16:1997;3866-3876.
15. Choi J.H., Adames N.R., Chan T.F., Zeng C., Cooper J.A., Zheng X.F. TOR signaling regulates microtubule structure and function. Curr. Biol. 10:2000;861-864.
16. Chong M.S., Woolf C.J., Andrews P., Turmaine M., Schreyer D.J., Anderson P.N. The downregulation of GAP-43 is not responsible for the failure of regeneration in freeze-killed nerve grafts in the rat. Exp. Neurol. 129:1994;311-320.
17. Dawson T.M., Steiner J.P., Lyons W.E., Fotuhi M., Blue M., Snyder S.H. The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain relationship to calcineurin . NeuroReport. 62:1994;569-580.
18. Fansa H., Keilhoff G., Horn T., Altmann S., Wolf G., Schneider W. [Stimulation of Schwann cell growth and axon regeneration of peripheral nerves by the immunosuppressive drug FK 506]. Handchir. Mikrochir. Plast. Chir. 31:1999;323-329.
19. Gold B.G. FK506 and the role of immunophilins in nerve regeneration. Mol. Neurobiol. 15:1997;285-306.
20. Gold B.G., Densmore V., Shou W., Matzuk M.M., Gordon H.S. Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J. Pharmacol. Exp. Ther. 289:1999;1202-1210.
21. Gold B.G., Katoh K., Storm Dickerson T. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J. Neurosci. 15:1995;7509-7516.
22. Gold B.G., Storm-Dickerson T., Austin D.R. The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor. Neurol. Neurosci. 6:1994;287-296.
23. Gold B.G., Zeleny-Pooley M., Chaturvedi P., Wang M.S. Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration. NeuroReport. 9:1998;553-558.
24. Hamilton G.S., Steiner J.P. Immunophilins beyond immunosuppression . J. Med. Chem. 41:1998;5119-5143.
25. Jayaraman T., Brillantes A.M., Timerman A.P., Fleischer S., Erdjument-Bromage H., Tempst P., Marks A.R. FK506 binding protein associated with the calcium release channel (ryanodine receptor). J. Biol. Chem. 267:1992;9474-9477.
26. Lyons W.E., George E.B., Dawson T.M., Steiner J.P., Snyder S.H. Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc. Natl. Acad. Sci. USA. 91:1994;3191-3195.
27. Lyons W.E., Steiner J.P., Snyder S.H., Dawson T.M. Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J. Neurosci. 15:1995;2985-2994.
28. Madsen J.R., MacDonald P., Irwin N., Goldberg D.E., Yao G.L., Meiri K.F., Rimm I.J., Stieg P.E., Benowitz L.I. Tacrolimus (FK506) increases neuronal expression of GAP-43 and improves functional recovery after spinal cord injury in rats. Exp. Neurol. 154:1998;673-683.
29. Mason M.R.J., Lieberman A.R., Grenningloh G., Anderson P.N. Transcriptional control of SCG10 and CAP-23 is correlated with the regeneration of the axons of peripheral and central neurons in vivo. Mol. Cell Neurosci. 20:2002;595-615.
30. Morrow D.R., Campbell G., Lieberman A.R., Anderson P.N. Differential regenerative growth of CNS axons into tibial and peroneal nerve grafts in the thalamus of adult rats. Exp. Neurol. 120:1993;60-69.
31. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, Sydney.
32. Richardson P.M., McGuinness U.M., Aguayo A.J. Axons from CNS neurons regenerate into PNS grafts. Nature. 284:1980;264-265.
33. Sharkey J., Crawford J.H., Butcher S.P., Marston H.M. Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats. Stroke. 27:1996;2282-2286.
34. Shou W., Aghdasi B., Armstrong D.L., Guo Q., Bao S., Charng M.J., Mathews L.M., Schneider M.D., Hamilton S.L., Matzuk M.M. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature. 391:1998;489-492.
35. Steiner J.P., Connolly M.A., Valentine H.L., Hamilton G.S., Dawson L., Hester L., Snyder S.H. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs. Nat. Med. 3:1997;421-428.
36. Steiner J.P., Dawson T.M., Fotuhi M., Glatt C.E., Snowman A.M., Cohen N., Snyder S.H. High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature. 358:1992;584-587.
37. Strittmatter S.M., Fankhauser C., Huang P.L., Mashius H., Fishman M.C. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell. 80:1995;445-452.
38. Sugawara T., Itoh Y., Mizoi K. Immunosuppressants promote adult dorsal root regeneration into the spinal cord. NeuroReport. 10:1999;3949-3953.
39. Tokime T., Nozaki K., Kikuchi H. Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. Neurosci. Lett. 206:1996;81-84.
40. Vaudano E., Campbell G., Hunt S.P., Lieberman A.R. Axonal injury and peripheral nerve grafting in the thalamus and cerebellum of the adult rat upregulation of c-jun and correlation with regenerative potential . Eur. J. Neurosci. 10:1998;2644-2656.
41. Wang M.S., Gold B.G. FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft. J. Spinal Cord. Med. 22:1999;287-296.
42. Wang T., Li B.Y., Danielson P.D., Shah P.C., Rockwell S., Lechleider J., Martin J., Manganaro T., Donahoe P.K. The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors. Cell. 86:1996;435-444.
43. Zhang Y., Campbell G., Anderson P.N., Martini R., Schachner M., Lieberman A.R. Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts I. Neural cell adhesion molecules. J. Comp. Neurol. 361:1995;193-209.
44. Zhang Y., Campbell G., Anderson P.N., Martini R., Schachner M., Lieberman A.R. Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts. II. Tenascin-C. J. Comp. Neurol. 361:1995;210-224.