Binding of a N,N′-bisheteryl derivative of dispirotripiperazine to heparan sulfate residues on the cell surface specifically prevents infection of viruses from different families

Virology

Volumn 311, Issue 1, 2003, Pages 134-143

  Schmidtke, M ^a   Karger, A ^b   Meerbach, A ^a   Egerer, R ^a   Stelzner, A ^a   Makarov, V ^c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^c Organic Intermediates and Dyes Institute   (Russian Federation)

Author keywords

Dispirotripiperazines; Heparan sulfate; Prevention of virus infection; Receptor; Virus

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; DSTP 27; FOSCARNET; HEPARAN SULFATE; N,N' BIS(1 OXIDO[1,2,5]OXADIAZOLO[3,4 D]PYRIMIDIN 7 YL) 3,12 DIAZA 6,9 DIAZONIA[5,2,5,2[DISPIROHEXADECANE DICHLORIDE; PENTOSAN POLYSULFATE; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL SURFACE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG BINDING; EMBRYO; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; INFECTION PREVENTION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; TITRIMETRY; VIRUS ADSORPTION; VIRUS INFECTION; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; HUMAN HERPESVIRUS 5; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; RESPIRATORY SYNCYTIAL VIRUS; SIMPLEXVIRUS; SUID HERPESVIRUS 1;

EID: 0038384133     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0042-6822(03)00166-1     Document Type: Article

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