Synthesis, cytotoxicity and antiviral activity of N,N′-bis-5-nitropyrimidyl derivatives of dispirotripiperazine

Antiviral Research

Volumn 55, Issue 1, 2002, Pages 117-127

  Schmidtke, M ^a   Riabova, O ^b   Dahse, H M ^c   Stelzner, A ^a   Makarov, V ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b NIOPIK State Sci Ctr Russ Fed   (Russian Federation)

^c HANS KNÖLL INSTITUTE   (Germany)

Author keywords

5 Nitropyrimidine; Antiviral; Dispirotripiperazine; Herpes simplex virus type 1

Indexed keywords

3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; 3,13 BIS(2 OXIRANYLMETHYL) 3,13 DIAZA 7,10 DIAZONIADISPIRO[6.2.6.2]OCTADECANE DIBROMIDE; N,N' BIS(1 OXIDO[1,2,5]OXADIAZOLO[3,4 DEXTRO]PYRIMIDIN 7 YL) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 AMINO 4 HYDROXY 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 CHLOROETHYL)CARBOXAMIDE 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 METHYL 4 CHLORO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 METHYL 4 HEXAMETHYLENIMINO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 METHYL 4 HYDROXY 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 METHYL 4 PYRROLIDINO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 METHYLMERCAPTO 4 CHLORO 5 FORMYLPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 METHYLMERCAPTO 4 CHLORO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 METHYLMERCAPTO 5 ETHOXYCARBONYLPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(2 TRIFLUOROMETHYL 4 CHLORO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(3 CHLOROPROPANAMIDE) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 CHLORO 2 METHYLTHIO 5 NITROPYRIMIDYL 6) 3,13 DIAZA 7,10 DIAZONIA(6,2,6,2)DISPIROOCTADECANE DIBROMIDE; N,N' BIS(4 CHLORO 5 AMINOPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 CHLORO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 CHLORO 5 NITROPYRIMIDYL 6)AMINO 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 DIETHYLDITHIOCARBAMOYL 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 HEXAMETHYLENIMINO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 HYDROXY 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 METHOXY 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 PHENYLBUTANONE 1) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(4 PYRROLIDINO 5 NITROPYRIMIDYL 6) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS(5 METHYL 1 OXIDO[1,2,5]OXADIAZOLO[3,4 DEXTRO]PYRIMIDIN 7 YL) 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BIS[[4 (N' DIETHYLAMINOCARBAMOYL)PIPERAZINE] 5 NITROPYRIMIDYL 6] 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BISAMINO 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; N,N' BISCHLOROMETHYL 3,12 DIAZA 6,9 DIAZONIA(5,2,5,2)DISPIROHEXADECANE DICHLORIDE; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; SPIRO COMPOUND;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DENSITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; GROWTH INHIBITION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS ADSORPTION; VIRUS INHIBITION; VIRUS REPLICATION; ANIMAL; CELL LINE; CERCOPITHECUS; COMPARATIVE STUDY; DOG; DOSE RESPONSE; DRUG EFFECT; HELA CELL; PHYSIOLOGY; SYNTHESIS;

ANIMAL; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; COMPARATIVE STUDY; CYTOPATHOGENIC EFFECT, VIRAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HERPESVIRUS 1, HUMAN; HUMAN; PIPERAZINES; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION; ANIMALS; HUMANS;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0035997940     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(02)00014-1     Document Type: Article

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