State of hepatocyte transplantation: A risk or a chance?;Stand der hepatozytentransplantation: Risiko oder chance?

Zentralblatt fur Chirurgie

Volumn 128, Issue 4, 2003, Pages 283-290

  Leckel, Kerstin ^a   Blaheta, R A ^b   Markus, B H ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Alternative cell sources; Hepatocyte culture systems; Hepatocyte transplantation; Metabolic deficiencies; Stem cells

Indexed keywords

ANIMAL CELL; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL TRANSPLANTATION; CLINICAL ARTICLE; EMBRYO; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CULTURE; LIVER FAILURE; METABOLIC DISORDER; NONHUMAN; REVIEW; STEM CELL TRANSPLANTATION;

ANIMALS; CELLS, CULTURED; HEPATOCYTES; HUMANS; LIVER FAILURE; METABOLISM, INBORN ERRORS; TREATMENT OUTCOME;

EID: 0038375047     PISSN: 0044409X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-38791     Document Type: Review

References (77)

1. Auth MK, Keitzer RA, Scholz M, Blaheta RA, Hottenrott EC, Herrmann G, Encke A, Markus BH. Establishment and immunological characterization of cultured human gallbladder epithelial cells. Hepatology 1993; 18: 546-555
2. Baccarani U, Donini A, Risaliti A, Piccolo G, Dialti V, Cautero N, Degrassi A, Sirchia G, Bresadola F. Steatotic versus cirrhotic livers as a source for human hepatocyte isolation. Transplant Proc 2001; 33: 664-665
3. Bader A, Knop E, Boker K, Fruhauf N, Schuttler W, Oldhafer K, Burkhard R, Pichlmaayr R, Sewing KF. A novel bioreactor design for in vitro reconstruction of in vivo liver characteristics. Artif Organs 1995; 19: 368-374
4. Benedetti E, Kirby JP, Asolati M, Blanchard J, Ward MG, Williams R, Hewett TA, Fontaine M, Pollak R. Intrasplenic hepatocyte allotransplantation in dalmatian dog with and without cyclosporine immunosuppression. Transplantation 1997; 63: 1206-1209
5. Berthiaume F, Moghe PV, Toner M, Yarmush ML. Effect of extracellular matrix topology on cell structure, function, and physiological responsivness: hepatocytes cultured in a sandwich configuration. FASEB J 1996; 10: 1471-1484
6. Bhatia SN, Balls UJ, Yarmush ML, Toner M. Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J 1999; 13: 1883-1900
7. Bilir BM, Guinette D, Karrer F, Kumpe DA, Krysl J, Stephens J, McGavran L, Ostrowska A, Durham J. Hepatocyte transplantation in acute liver failure. Liver Transpl 2000; 6: 32-40
8. Block GD, Locker J, Bowen WC, Peterson BE, Katyal S, Strom SC, Riley T, Howard TA, Michalopoulos GK. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol 1996; 132: 1133-1149
9. Bruni S, Chang TM. Kinetic analysis of UDP-glucuronosyltransferase in bilirubin conjugation by encapsulated hepatocytes for transplantation in Gunn rats. Artif Organs 1995; 19: 449-457
10. Busse B, Gerlach JC. Bioreactors for hybrid liver support: histological aspects and novel designs. Ann N Y Acad Sci 1999; 875: 326-339
11. Busse B, Smith MD, Gerlach JC. Treatment of acute liver failure: hybrid liver support. A critical overview. Langenbecks Arch Surg 1999; 384: 588-599
12. Clement B, Guguen-Guillouzo C, Grimaud J, Rissel M, Guillouzo A. Effect of hydrocortisone on deposition of types I and IV collagen in primary culture of rat hepatocytes. Cell Mol Biol 1988; 34: 449-460
13. Dunn TB, Kumins NH, Raofi V, Holman DM, Mikalov M, Blanchard J, Law WR, Rastellini C, Benedetti E. Multiple intrasplenic hepatocyte transplantation in the dalmatian dog. Surgery 2000; 127: 193-199
14. Eguchi S, Rozga J, Lebow LT, Chen SC, Wang CC, Rosenthal R, Fogli L, Hewitt WR, Middleton Y, Demetriou AA. Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus. Transplantation 1996; 62: 588-593
15. Eurotransplant International Foundation:. Annual Report 2000
16. Fisher RA, Bu D, Thompson M, Tisnado J, Prasad U, Sterling R, Posner M, Strom S. Defining hepatocellular chimerism in a liver failure patient bridged with hepatocyte infusion. Transplantation 2000; 69: 303-307
17. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NI, Warkentin PI, Dorko K, Sauter BV, Strom SC. Treatment of the Crigler-Najjar Syndrome Type I with hepatocyte transplantation. N Engl J Med 1998; 338: 1422-1426
18. Gagandeep S, Rajvanshi P, Sokhi RP, Slehria S, Palestro CJ, Bhargava KK, Gupta S. Transplanted hepatocytes engraft, survive, and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis. J Pathol 2000; 191: 78-85
19. Gagandeep S, Sokhi R, Slehria S, Gorla GR, Furgiuele J, DePinho RA, Gupta S. Hepatocyte transplantation improves survival in mice with liver toxicity induced by hepatic overexpression of Mad1 transcription factor. Mol Ther 2000; 1: 358-365
20. Gerlach JC. Development of a hybrid liver support system: a review. Int J Artif Organs 1996; 19: 645-654
21. Gottlieb DI, Huettner JE. An in vitro pathway from embryonic stem cells to neurons and glia. Cells Tissues Organs 1999; 165: 165-172
22. Gregory PG, Conolly CK, Toner M, Sullivan SJ. In vitro characterization of porcine hepatocyte function. Cell Transplant 2000; 9: 1-10
23. Grompe M. Therapeutic liver repopulation for the treatment of metabolic liver diseases. Hum Cell 1999; 12: 171-180
24. Guha C, Parashar B, Deb NJ, Sharma A, Gorla GR, Alfieri A, Roy-Chowdhury N, Roy-Chowdhury J, Vikram B. Liver irradiation: a potential preparative regimen for hepatocyte transplantation. Int J Radiat Oncol Biol Phys 2001; 49: 451-457
25. Harper AM, McBride MA, Ellison ED. The UNOS OPTN waiting list, 1988-1998. Clin Transpl 1999; 71-82
26. Hescheler J, Fleischmann BK, Wartenberg M, Bloch W, Kolossov E, Ji G, Addicks K, Sauer H. Establishment of ionic channels and signalling cascades in the embryonic stem cell-derived primitive endoderm and cardiovascular system. Cells Tissues Organs 1999; 165: 153-164
27. Hino O, Kitagawa T, Nomura K, Ohtake K, Cui L, Furuta Y, Aizawa S. Hepatocarcinogenesis in transgenic mice carrying albumin-promoted SV40 Tantigen gene. Jpn J Cancer Res 1991; 82: 1226-1233
28. Hodgkinson CP, Wright MC, Paine AJ. Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribunuclease activity. Mol Pharmacol 2000; 58: 976-981
29. Hole N. Embryonic stem cell-derived haematopoiesis. Cells Tissues Organs 1999; 165: 181-189
30. Ikebukuro H, Inagaki M, Mito M, Kasai S, Ogawa K, Nozawa M. Prolonged function of hepatocytes transplantated into the spleens of Ngase analbumineic rats. Eur Surg Res 1999; 31: 39-47
31. Kamohara Y, Rozga J, Demetriou AA. Artifical liver: review and Cedars-Sinai experience. J Hepatobiliary Pancreat Surg 1998; 5: 273-285
32. Keeffe EB. Liver transplantation current status and novel approaches to liver replacement. Gastroenterology 2001; 120: 749-762
33. Kim WH, Lee JH, Han SU, Jin YM, Kwak YS, Wang HJ, Kim MW. Systematic analysis of the effects of hepatocyte transplantation on rats with acute liver failure. Hepatogastroenterology 2000; 47: 371-374
34. Kobayashi N, Noguchi H, Fujiwara T, Tanaka N. Xenotransplantation of immotalized human hepatocytes for experimental acute liver failure in rats. Transplant Proc 2000; 32: 1123-1124
35. Kocken JM, Borel Rinkes IH, Bijma AM, de Roos WK, Bowman E, Terpstra OT, Sinaasappel M. Correction of an inborn error of metabolism by intraportal hepatocyte transplantation in a dog model. Transplantation 1996; 62: 358-364
36. Kono Y, Yang S, Roberts EA. Extendet primary culture of human hepatocytes in a collagen gel sandwich system. In Vitro Cell Dev Biol Anim 1997; 33: 467-472
37. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000; 6: 1229-1234
38. Leckel K, Blaheta RA, Boost KA, Kim HJ, Markus BH. In-vitro Analysen zum klinischen Einsatz isolierter humaner Hepatozyten. Chirurgisches Forum 2001 für experimentelle und klinische Forschung. Forumband 2001; 30: 281-283
39. Leckel K, Blaheta RA, Boost KA, Krätschell R, Auth MK, Markus BH. Development of a cell culture modell to allow controlled modification of the differentiation status of human hepatocytes. Zur Publikation eingereicht in J Hepatol
40. Lee J, Morgan JR, Tompkins RG, Jarmush ML. Proline-mediated enhancement of hepatocyte function in a collagen sandwich culture configuration. FASEB L 1993; 7: 586-591
41. LeTissier P, Stoye JP, Takeuchi Y, Patience C, Weiss RA. Two sets of human-topic pig retrovirus. Nature 1997; 389: 681-682
42. Malhi H, Gupta S. Hepatocyte transplantation: new horizons and challenges. J Hepatobiliary Pancreat Surg 2001; 8: 40-50
43. Markus PM, Becker H. Hepatocelluläre Transplantation - von den Anfängen bis zum klinischen Einsatz. Chirurg 1999; 70: 162-168
44. Michalopoulos GK, Bowen W, Nussler AK, Becich MJ, Howard TA. Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen gels. J Cell Physiol 1993; 156: 443-452
45. Mitchell C, Mignon A, Guidotti JE, Besnard S, Fabre M, Duverger N, Parlier D, Tedgui A, Kahn A, Gilgenkrantz H. Therapeutic liver repopulation in a mouse model of hypercholesterolemia. Hum Mol Genet 2000; 9: 1597-1602
46. Mito M, Kusano M, Kawaura Y. Hepatocyte transplantation in man. Transplant Proc 1992; 24: 3052-3053
47. Naik S, Trenkler D, Santangini H, Pan J, Jaureguitto HO. Isolation and culture of porcine hepatocytes for artificial liver support. Cell Transplant 1996; 5: 107-115
48. Nakamura J, Okamoto T, Schumacher IK, Tabei I, Chowdhury NR, Chowdhury JR, Fox IJ. Treatment of surgically induced acute liver failure by transplantation of conditionally immortalised hepatocytes. Transplantation 1997; 63: 1541-1547
49. Nozawa K, Kurumiya Y, Yamamoto A, Isobe Y, Suzuki M, Yoshida S. Up-regulation of telomerase in primary cultured rat hepatocytes. J Biochem 1999; 126: 361-367
50. Nyberg SL, Remmel RP, Mann HJ, Peshwa MV, Hu WS, Cerra FB. Primary hepatocytes outperform Hep G2 cells as a source of biotransformation functions in a bioartifical liver. Ann Surg 1994; 220: 59-67
51. Oren R, Dabeva MD, Petkov PM, Hurston E, Laconi E, Shafritz DA. Restoration of serum albumin levels in nagase analbumineic rats by hepatocyte transplantation. Hepatology 1999; 29: 75-81
52. Osawa M, Hanada K, Hamada H, Nakauchi H. Long-tern lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996; 273: 242-245
53. Ott M, Schmidt HH, Cichon G, Manns MP. Emerging therapies in hepatology: liver-directed gene transfer and hepatocyte transplantation. Cells Tissues Organs 2000; 167: 8187
54. Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. Nat Med 1997; 54: 282-286
55. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, Goff JP. Bone marrow as a potential source of hepatic oval cells. Science 1999; 284: 1168-1170
56. Puviani AC, Ottolenghi C, Tassinari B, Pazzi P, Marsiani E. An update on high-yield hepatocyte isolation methods and on the potential clinical use of isolated liver cells. Comp Biochem Physiol 1998; 121: 99-109
57. Ransford R, Gunson B, Mayer D, Neuberger J, Christensen E. Effect on outcome of the lengthening waiting list for liver transplantation. Gut 2000; 47: 441-443
58. Raper SE, Grossmann M, Rader DJ, Thoene JG, Clark BJ 3rd, Kolansky DM, Muller DW, Wilson JM. Safety and feasibility of liver directed gene therapy for homozygous familial hypercholesterolemia. Ann Surg 1996; 223: 116-126
59. Reyes J, Rubenstein WS, Mieles L. The use of cultured hepatocyte infusion via the portal vein for the treatment of ornithine transcarbamylase deficiency by transplantation of enzymatically competent ABO/Rh-matched cells. Hepatology 1996; 24: 308-313
60. Riordan SM, Williams R. Acute liver failure: targeted artificial and hepatocyte-based support of liver regeneration and reversal mutiorgan failure. J Hepatol 2000; 32: 63-76
61. Riordan SM, Williams R. Extracorporal support and hepatocyte transplantation in acute liver failure and cirrhosis. J Gastroenterol Hepatol 1999; 14: 757-770
62. Rodes J, Navasa M. Liver transplantation and quality of live. Can J Gatroenterol 2000; 14: 693-699
63. Rozga J, Morsiani E, LePage AD, Morsiani E, Moscioni AD, Hoffman A, Sher L, Villamil F, Woolf G, McGrath M. A bioartificial liver to treat severe acute liver failure. Ann Surg 1994; 219: 538-544
64. Schroder AJ, Blaheta RA, Scholz M, Encke A, Markus BH. Isolation and separation of human adult hepatocytes from resected liver: cellular yield and purity using different methods. Zentralbl Chir 1994; 119: 127-138
65. Schroder AJ, Blaheta RA, Scholz M, Kronenberger B, Encke A, Markus BH. Effects of proinflammatory cytokines on cultivated primary human hepatocytes. Fluorometric measurement of intercellular adhesion molecule-1 and human leukocyte antigen -A, -B, -C, and -DR expression. Transplantation 1995; 59: 1023-1028
66. Sierra E, Maganto P, Codesal J, Mula N, Cubero J, Arza E, Castillo-Olivares JL, Arahuetes RM. Liver gene expression and increase in albumin synthesis by fetal hepatocytes transplanted into analbuminemic rats. Life Sci 2000; 67: 2417-2432
67. Stange J, Mitzner S. Cell sources for bioartifical liver support. Int J Artif Organs 1996; 19: 14-17
68. Stevens LC. The origin and development of testicular, ovarian, and embryo-derived teratomas. In: Silver LM, Martin GR, Strickland S (Hrsg). Teratocarcinoma Stem Cells. Cold Spring Harbor Laboratora Press, Cold Spring Harbor, New York 1983; 23-36
69. Strom SC, Chowdhury JR, Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis 1999; 19: 39-48
70. Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Ham JM, Posner MP. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997; 63: 559-569
71. Sundback CA, Vacanti JP. Alternatives to liver transplantation: from hepatocyte transplantation to tissue-engineered organs. Gastroenterology 2000; 118: 438-442
72. Suc B, Chalem Y, Golmard JL. Analysis of the French liver transplant waiting list, 1992-1996. Transplantation 2000; 69: 515-522
73. Sugiyama N, Eguchi S, Kawazoe Y, Miyamoto S, Kamohara Y, Fujioka H, Furui J, Sato M, Ishii T, Kanematsu T. Intraportal administration of lowdose recombinant human hepatocyte growth factor anhances effects of hepatocellular transplantation. Hepatogastroenterology 2000; 47: 1245-1249
74. Sutherland DE, Numata M, Matas AJ, Simmons RL, Najarian JS. Hepatocellular transplantation in acute liver failure. Surgery 1997; 82: 124-132
75. Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000; 31: 235-240
76. Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science 2000; 287: 1427-1430
77. Wiederkehr JC, Kondos GT, Pollak R. Hepatocyte transplantation for the low-density lipoprotein receptor-deficient state. A study in the Watanabe rabbit. Transplantation 1990; 50: 466-471