Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis

Cell Biology and Toxicology

Volumn 19, Issue 3, 2003, Pages 135-143

  Wu, X ^a   Biswal, S S ^b   Kehrer, James P ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b The Johns Hopkins University   (United States)

Author keywords

5 lipoxygenase activating protein; Apoptosis; MK886; Overexpression; Transfection

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5-LIPOXYGENASE-ACTIVATING PROTEIN; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CARRIER PROTEIN; COMPLEMENTARY DNA; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ETOPOSIDE; INDOLE DERIVATIVE; INTERLEUKIN 3; ISOENZYME; LIPOXYGENASE INHIBITOR; MEMBRANE PROTEIN; MESSENGER RNA; NORDIHYDROGUAIARETIC ACID; ONCOPROTEIN; PROSTAGLANDIN SYNTHASE; PROTEIN BAX; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL COUNT; CELL CULTURE; CELL DENSITY; CELL DIVISION; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; GROWTH RATE; METABOLISM; MOUSE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROLYMPHOCYTE; PROMOTER REGION; PROTEIN LOCALIZATION; STEM CELL;

ANIMALS; APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; B-LYMPHOCYTES; BCL-2-ASSOCIATED X PROTEIN; CARRIER PROTEINS; CELL COUNT; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; INDOLES; ISOENZYMES; LIPOXYGENASE INHIBITORS; MEMBRANE PROTEINS; MICE; NORDIHYDROGUAIARETIC ACID; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TRANSFECTION;

ANIMALIA; CUCUMBER MOSAIC VIRUS; MURINAE;

EID: 0038367239     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024789810277     Document Type: Article

References (33)

1. Anderson KM, Levin J, Jajeh A, Seed T, Harris JE. Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase. Prostaglandins Leukot Essen Fatty Acids 1993;48:323-6.
2. Anderson KM, Seed T, Plate JMD, Jajeh A, Meng J, Harris JE. Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis. Leuk Res. 1995;19:789-801.
3. Anderson KM, Seed T, Jajeh A, et al. An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells. Anticancer Res. 1996;16:2599-600.
4. Avis IM, Jett M, Boyle T, et al. Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling. J Clin Invest. 1996;97:806-13.
5. Battu S, Beneytout JL, Pairet M, Rigaud M. Cyclooxygenase-2 up-regulation after FLAP transfection in human adenocarcinoma cell line HT29 c1.19A. FEBS Lett. 1998;437:49-55.
6. Biswal SS, Datta K, Shaw SD, Feng X, Robertson JD, Kehrer JP. Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells. Toxicol Sci. 2000;53:77-83.
7. Biswal SS, Datta K, Kehrer JP. Association between bcl-xL and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells. Toxicology. 2001;160:97-103.
8. Buyn T, Dudeja P, Harris JE, et al. A 5-lipoxygenase inhibitor at micromolar concentration raises intracellular calcium in U937 cells prior to their physiologic cell death. Prostaglandins Leukot Essen Fatty Acids. 1997;56:69-77.
9. Claesson H-K, Jakobsson P-J, Steinhilber D, Odlander B, Samuelsson B. Expression of 5-lipoxygenase and biosynthesis of leukotriene b4 in human monomorphonuclear leukocytes. J Lipid Mediat. 1993;6:15-22.
10. Coe NB, Bernlohr DA. Physiological properties and functions of intracellular fatty acid-binding proteins. Biochim Biophys Acta 1998;1391:287-306.
11. L expression in murine pro B-lymphocytic FL5.12 cells. J Biol Chem. 1998;273:28163-9.
12. Datta K, Biswal SS, Kehrer JP. The 5-lipoxygenase activating protein (FLAP) inhibitor, MK886, induces apoptosis independent of FLAP. Biochem J. 1999;340:371-5.
13. L in FL5.12 cells undergoing apoptosis induced by MK886. Toxicol Appl Pharmacol. 2001;174:273-81.
14. el Makhour-Hojeij Y, Baclet MC, Chable-Rabinovitch H, Beneytout JL, Cook J. Expression of 5-lipoxygenase in lymphoblastoid B and T cells. Prostaglandins. 1994;48:21-9.
15. Ghosh J, Myers CE. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc Natl Acad Sci USA 1998;95:13182-7.
16. Glatz JFC, Vork MM, Cistola DP, van der Vusse GJ. Cytoplasmic fatty acid-binding protein: significance for intracellular transport of fatty acids and putative role in signal transduction pathways. Prostaglandins Leukot Essent Fatty Acids. 1993;48:33-41.
17. Glatz JFC, Borchers T, Spener F, Van der Vusse GJ. Fatty acids in cell signalling: modulation by lipid binding proteins. Prostaglandins Leukot Essent Fatty Acids. 1995;52:121-7.
18. Glatz JFC, van Nieuwenhoven FA, Luiken JJFP, Schaap FG, van der Vusse GJ. Role of membrane-associated and cytoplasmic fatty acid binding proteins in cellular fatty acid metabolism. Prostaglandins Leukot Essent Fatty Acids. 1997;57:373-8.
19. Gugliucci A, Ranzato L, Scorrano L, et al. Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors. J Biol Chem. 2002; 277:31789-95.
20. Kargman S, Rousseau P, Reid GK, et al. Leukotriene synthesis in U937 cells expressing recombinant 5-lipoxygenase. J Lipid Mediat. 1993;7:31-45.
21. Koller M, Wachtler P, David A, Muhr G, Konig W. Arachidonic acid induces DNA-fragmentation in human polymorphonuclear neutrophil granulocytes. Inflammation. 1997; 21:463-74.
22. La E, Kern JC, Atarod EB, Kehrer JP. Fatty acid release and oxidation in lipoxygenase inhibitor-induced apoptosis. Toxicol Lett. 2003;138:193-203.
23. Lee JC, Hapel AJ, Ihle JN. Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line. J Immunol. 1982;128:2393-8.
24. Penzo D, Tagliapietra C, Colonna R, Petronilli V, Bernardi P. Effects of fatty acids on mitochondria: implications for cell death. Biochim Biophys Acta. 2002;1555:160-5.
25. Potter H. Introduction of DNA into mammalian cells-transfection by electroportion. In: Current protocols in molecular biology. New York: John Wiley; 1996; section 9.3.
26. Ramakrishnan N, Kalinich JF, McClain DE. Ebselen inhibition of apoptosis by reduction of peroxides. Biochem Pharmacol. 1996;51:1443-51.
27. Sandstrom PA, Tebbey PW, Van Cleave S, Buttke TM. Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency. J Biol Chem. 1994;269:798-801.
28. Sandstrom PA, Pardi D, Tebbey PW, et al. Lipid hydroperoxide-induced apoptosis: lack of inhibition by Bcl-2 over-expression. FEBS Lett. 1995;365:66-70.
29. Scorrano L, Penzo D, Petronilli V, Pagano F, Bernardi P. Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-a apoptotic signaling. J Biol Chem. 2001;276:12035-40.
30. Tang DG, Chen YQ, Honn KV. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci USA 1996;93:5241-6.
31. Tang DG, La E, Kern J, Kehrer JP. Fatty acid oxidation and signaling in apoptosis. Biol Chem. 2002;383:425-42.
32. Vickers PJ. 5-Lipoxygenase activating protein (FLAP). J Lipid Mediat Cell Signal. 1995;12:185-94.
33. Woods JW, Coffey MJ, Brock TG, Singer II, Peters-Golden M. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J Clin Invest. 1995;95:2035-46.