The oral efficacy of vardenafil hydrochloride for inducing penile erection in a conscious rabbit model

Journal of Urology

Volumn 165, Issue 4, 2001, Pages 1316-1318

  Bischoff, E ^a   Niewoehner, U ^a   Haning, H ^a   Es Saved, M ^a   Schenke, T ^a   Schlemmer, K H ^a  

^a BAYER AG   (Germany)

Author keywords

Impotence; Penile erection; Phosphodiesterase inhibitors; Rabbits

Indexed keywords

CYCLIC GMP PHOSPHODIESTERASE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG; VARDENAFIL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG POTENTIATION; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RABBIT; SEXUAL AROUSAL;

EID: 0035092722     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)69891-4     Document Type: Article

References (16)

1. Physiology of penile erection
2. The influence of medication on erectile dysfunction
3. Nitric oxide and cyclic GMP formation upon electric field stimulation cause relaxation of corpus cavernosum smooth muscle
4. The role of nitric oxide in erectile function
5. Nitric oxide in the penis: Physiology and pathology
6. Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
7. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells
8. Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile function in the anesthetized dog
9. The rabbit as a model for neurourologic studies of the lower genitourinary tract
10. Neuroleptics induce penile erection in the rabbit
11. A conscious rabbit model is able to demonstrate the efficacy of vardenafil and sildenafil on penile erection
12. Vardenafil a potent and selective inhibitor of phosphodiesterase type5 increases cGMP in rabbit corpus cavernosum
13. Relationship between contraction and relaxation in human and rabbit corpus cavernosum
14. The rabbit as an intracavernous injection study model
15. Intracavernous application of SIN-1 in rabbit and man: Functional and toxicological results
16. Effects of the nitric oxide synthase inhibitor NG nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit