Developmental regulation of a neuron-specific neurofibromatosis 1 isoform

Annals of Neurology

Volumn 46, Issue 5, 1999, Pages 777-782

  Gutmann, David H ^a   Zhang, Yujing ^a   Hirbe, Angela ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROFIBROMIN;

ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BRAIN CORTEX; CONTROLLED STUDY; CYTOPLASM; FOREBRAIN; LEARNING DISORDER; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEUROFIBROMATOSIS; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ALTERNATIVE SPLICING; ANIMALS; ANIMALS, NEWBORN; BRAIN; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYONIC AND FETAL DEVELOPMENT; EXONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, NEUROFIBROMATOSIS 1; MICE; NERVE TISSUE PROTEINS; NEUROFIBROMIN 1; NEURONS; PROTEIN ISOFORMS; PROTEINS;

EID: 0032704272     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199911)46:5<777::AID-ANA15>3.0.CO;2-H     Document Type: Article

References (19)

1. Gutmann DH, Aylsworth A, Carey JC, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:51-57
2. North KK, Riccardi V, Samango-Sprouse C, et al. Cognitive function and academic performance in neurofibromatosis 1: consensus statement from the NF1 Cognitive Disorders Task Force. Neurology 1997;48:1121-1127
3. Gutmann DH, Andersen LB, Cole JL, et al. An alternatively spliced mRNA in the carboxyl terminus of the neurofibromatosis type 1 (NF1) gene is expressed in muscle. Hum Mol Genet 1993;2:989-992
4. Gutmann DH, Geist RT, Rose K, Wright DE. Expression of two new protein isoforms of the neurofibromatosis type 1 gene product, neurofibromin, in muscle tissues. Dev Dyn 1995;202: 302-311
5. Huynh DP, Nechiporuk T, Pulst SM. Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. Dev Biol 1994;161:538-551
6. Gutmann DH, Geist RT, Wright DE, Snider WD. Expression of the neurofibromatosis 1 (NF1) isoforms in developing and adult rat tissues. Cell Growth Differ 1995;6:315-322
7. Danglot G, Regnier V, Fauvet D, et al. Neurofibromatosis 1 (NF1) mRNAs expressed in the central nervous system are differentially spliced in the 5′ part of the gene. Hum Mol Genet 1995;4:915-920
8. Geist RT, Gutmann DH. Expression of a developmentally regulated neuron-specific isoform of the neurofibromatosis 1 (NF1) gene. Neurosci Lett 1996;211:85-88
9. Geist RT, Reddy AJ, Zhang J, Gutmann DH. Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues. Neurobiol Dis 1996;3:111-120
10. Gutmann DH, Wood DL, Collins FS. Identification of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci USA 1991;88:9658-9662
11. Hewett SJ, Choi DW, Gutmann DH. Increased expression of the neurofibromatosis 1 (NF1) tumor suppressor gene protein, neurofibromin, in reactive astrocytes in vitro. Neuroreport 1995;6:1505-1508
12. DeClue JE, Cohen BD, Lowy DR. Identification and characterization of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci USA 1991;88:9914-9918
13. Nordlund M, Gu X, Shipley MT, Ratner N. Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons. J Neurosci 1993;13:1588-1600
14. Daston MM, Scrable H, Nordlund M, et al. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells and oligodendrocytes. Neuron 1992;8:415-428
15. Bain G, Kitchens D, Yao M, et al. Embryonic stem cells express neuronal properties in vitro. Dev Biol 1995;168:342-357
16. Daston MM, Ratner N. Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development. Dev Dyn 1993;195:216-226
17. Basu TN, Gutmann DH, Fletcher JA, et al. Aberrant regulation of ras proteins in tumour cells from type 1 neurofibromatosis patients. Nature 1992;356:713-715
18. Gregory PE, Gutmann DH, Boguski M, et al. The neurofibromatosis type 1 gene product, neurofibromin, associates with microtubules. Somat Cell Mol Genet 1993;19:265-274
19. Rose K, Goldberg MP, Choi DW. Cytotoxicity in murine cortical cell culture. In: Tyson CA, Frazier JM, eds. In vitro biological systems. San Diego: Academic Press, 1993:46-60