The effects of estrogen and Raloxifene treatment on antioxidant enzymes in brain and liver of ovarectomized female rats

Endocrine Research

Volumn 29, Issue 2, 2003, Pages 183-189

  Özgönül, Mert ^a   Öge, Ayşin ^b   Sezer, Ebru Demirel ^a   Bayraktar, Firat ^c   Sözmen, Eser Yildirim ^a,d  

^a EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b ADNAN MENDERES UNIVERSITY   (Turkey)

^c DOKUZ EYLUL UNIVERSITY   (Turkey)

^d EGE UNIVERSITY   (Turkey)

Author keywords

Catalase; Estrogen; Ovariectomy; Raloxifene; Superoxide dismutase

Indexed keywords

ANTIOXIDANT; BRAIN ENZYME; CATALASE; ESTROGEN; ETHINYLESTRADIOL; LIVER ENZYME; LY 13948; PLACEBO; RALOXIFENE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN TISSUE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; ESTROGEN THERAPY; FEMALE; LIVER; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RANK SUM TEST; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; BRAIN; CATALASE; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; LIVER; OVARIECTOMY; OXIDOREDUCTASES; RALOXIFENE; RATS; RATS, SPRAGUE-DAWLEY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SUPEROXIDE DISMUTASE;

EID: 0038345232     PISSN: 07435800     EISSN: None     Source Type: Journal    
DOI: 10.1081/ERC-120022299     Document Type: Article

References (19)

1. Berco M, Bhavnani BR. Differential neuroprotective effects of equine estrogens against oxidized low density lipoprotein-induced neuronal cell death. J Soc Gynecol Invest 2001; 8:245-254.
2. Garcia-Segura LM, Azcoitia I, DonCarlos LL. Neuroprotection by estradiol. Prog Neurobiol 2001; 63:29-60.
3. Gomez-Zubeldia MA, Arbues JJ, Hinchado G, Nogales AG, Millan JC. Influence of estrogen replacement therapy on plasma lipid peroxidation. Menopause 2001; 8:274-280.
4. Jain S, Saxena D, Kumar PG, Koide SS, Laloraya M. Effect of estradiol and selected anti-estrogens on pro- and antioxidant pathways in mammalian uterus. Contraception 1999; 60:111-118.
5. Klinger W, Lupp A, Karge E, Baumbach H, Eichhorn F, Feix A, Füldner F, Gernhardt S, Knels L, Kost B, Mertens G, Werner F, Oettel M, Römer W, Schwarz S, Elger W, Schneider B. Estradiol, testosterone, dehydroepiandrosterone and androstenedion: novel derivatives and enantiomers. Interactions with rat liver microsomal cytochrome P450 and antioxidant/radical scavenger activities in vitro. Toxicol Lett 2002; 128:129-144.
6. Thibodeu PA, Kachadourian R, Lemay R, Bisson M, Day BJ, Paquette B. In vitro pro- and antioxidant properties of estrogens. J Steroid Biochem Mol Biol 2002; 81:227-236.
7. Yoshie Y, Ohshima H. Synergistic induction of DNA strand breakage by catecholestrogen and nitric oxide: implications for hormonal carcinogenesis. Free Rad Biol Med 1998; 24:341-348.
8. Tang MX, Jacobs D, Stern Y. Effect of estrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996; 348:429-432.
9. Grandbois M, Morisette M, Callier S, Di Paolo T. Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice. Neuroreport 2000; 11:343-346.
10. Sozmen EY, Tanyalçin T, Kutay F, Onat T. Ethanol induced oxidative stress and membrane injury in rats. Eur J Clin Chem Clin Biochem 1994; 32:741-744.
11. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951; 193:265-275.
12. Liehr JG, Roy D. Free radical generation by redox cycling of estrogens. Free Rad Biol Med 1990; 8:415-423.
13. Kasapovic J, Pajovic SB, Kanazir DT, Martinovic JV. Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the rat liver. J Endocrinol Invest 1997; 20(4):203-206.
14. Ruiz-Larrea MB, Martin C, Martinez R, Navarro R, Lacort M, Miller NJ. Antioxidant activities of estrogen against aqueous and lipophilic radicals; differences between phenol and catechol estrogens. Chem Phys Lipids 2000; 105:179-188.
15. Zuckerman SH, Bryan N. Inhibition of LDL oxidation and myeloperoxidase dependent tyrosyl radical formation by the selective estrogen receptor modulator raloxifene. (LY139481 HCL), Atherosclerosis 1996; 126:65-75.
16. Black LJ, Sato M, Rowley ER, Magee DE, Bekele KA, Williams DC, Cullian GJ, Bendele R, Kauffman RF, Bensch WR, Frolik C, Temrine J, Bryant HU. Raloxifene prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest 1994; 93:63.
17. Wilson ME, Dubal DB, Wise PM. Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors. Brain Res 2000; 873:235-242.
18. Singh M, Setalo G Jr, Guan X, Warren M, Toran-Allerand CD. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neutrophin signaling pathways. J Neurosci 1999; 19:1179-1188.
19. Miranda RC, Sohrabji F, Toran-Allerand CD. Neuronal co-localization of mRNAs for neutrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. Proc Natl Acad Sci USA 1993; 90:6439-6443.