1H-imidazo[4,5-c]quinoline derivatives as novel potent TNF-α suppressors: Synthesis and structure-activity relationship of 1-, 2-and 4-substituted 1H-imidazo[4,5-c]quinolines or 1H-imidazo[4,5-c]pyridines

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 12, 2003, Pages 2541-2550

  Izumi, Tomoyuki ^a   Sakaguchi, Jun ^a   Takeshita, Makoto ^a   Tawara, Harumi ^a   Kato, Ken Ichi ^a   Dose, Hitomi ^a   Tsujino, Tomomi ^a   Watanabe, Yoshinari ^a   Kato, Hideo ^a  

^a Abbott Japan Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 1 [2 (1 BENZYL 4 PIPERIDYL)ETHYL] 1H IMIDAZO[4,5 C]QUINOLINE; 4 CHLORO 2 PHENYL 1 [2 (4 PIPERIDYL)ETHYL] 1H IMIDAZO[4,5 C]QUINOLINE; IMIQUIMOD; QUINOLINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROMETRY; INHIBITION KINETICS; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 0038334959     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00178-0     Document Type: Article

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