Butyrylcholinesterase-mediated enhancement of the enzymatic activity of trypsin

Cellular and Molecular Neurobiology

Volumn 21, Issue 3, 2001, Pages 285-296

  Darvesh, Sultan ^a,b,c   Kumar, Rohit ^b   Roberts, Sheila ^c   Walsh, Ryan ^c   Martin, Earl ^c  

^a Department of Medicine ^*  (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c MOUNT SAINT VINCENT UNIVERSITY   (Canada)

Author keywords

Acetylcholinesterase; Alzheimer; Butyrylcholinesterase; Trypsin

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CHOLINESTERASE; PEPTIDASE; TRYPSIN;

ALZHEIMER DISEASE; ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HYDROLYSIS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; BENZOYLARGININE NITROANILIDE; BUTYRYLCHOLINESTERASE; CHROMOGENIC COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; HYDROLYSIS; TRYPSIN;

EID: 0034850214     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010947205224     Document Type: Article

References (57)

1. The quaternary structure of chicken acetylcholinesterase and butyrylcholinesterase: Effect of collagenase and trypsin
2. Noncholinergic functions of cholinesterases
3. Peptidase activity exhibited by human serum pseudocholinesterase
4. Identification of the trypsin-like activity in commercial preparations of eel acetylcholinesterase
5. Monoclonal antibodies allow precipitation of esterasic but not peptidasic activities associated with butyrylcholinesterase
6. Cholinesterases display genuine aryl acylamidase activity but are totally devoid of intrinsic peptidase activities
7. Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine
8. Acetylcholinesterase hydrolyzes substance P
9. Alzheimer's disease: A disorder of cortical cholinergic innervation
10. Enzyme kinetics of butyrylcholinesterase and trypsin: Implications in Alzheimer's disease
11. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity
12. Proteolysis at the secretase and amyloidogenic cleavage sites of the beta-amyloid precursor protein by acetylcholineterase and butyrylcholinesterase using model peptide substrates
13. A new and rapid colorimetric determination of acetylcholinesterase activity
14. Enzyme histochemical studies of senile plaques
15. Activities of the enantiomers of cocaine and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase
16. Cholinesterase activity in the plaques, tangles and angiopathy of Alzheimer's disease does not emanate from amyloid
17. Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease
18. Cholinesterases and the pathology of Alzheimer disease
19. Butyrylcholinesterase: Is it important for cortical acetylcholine regulation?
20. Ultrastructural localization of butyrylcholinesterase on neurofibrillary degeneration sites in the brains of aged and Alzheimer's disease patients
21. Large-scale purification and long-term stability of human butyrylcholinesterase: A potential bioscavenger drug
22. Butyrylcholinesterase in the life cycle of amyloid plaques
23. Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse
24. Generalized kinetics of reversible inhibition and activation
25. Non-classical roles of cholinesterases in the embryonic brain and possible links to Alzheimer disease
26. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
27. Substance P hydrolysis by human serum cholinesterase
28. Loss of the interchain disulfide peptide and dissociation of the tetramer following limited proteolysis of native human serum cholinesterase
29. Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase
30. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions
31. A naturally occurring molecular form of human plasma cholinesterase is an albumin conjugate
32. Butyrylcholinesterase-catalyzed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters
33. Identification of a novel serine protease-like molecule in human brain
34. Transferrin and the growth-promoting effect of nerves
35. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
36. Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV
37. Studies on galactosyltransferase: Kinetic effects of α-lactalbumin with N-acetylglucosamine and glucose as galactosyl group acceptors
38. Degradation of acetylcholine in human airways: Role of butyrylcholinesterase
39. Regulation of APP cleavage by alpha-, beta- and gamma-secretases
40. Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease
41. Some cerebral proteins and enzyme systems in Alzheimer's presenile and senile dementia
42. Changes in brain cholinesterases in senile dementia of the Alzheimer type
43. Localization of the peptidase activity of human serum butyrylcholinesterase in a approximately 50-kDa fragment obtained by limited alpha-chymotrypsin digestion
44. The peptidase activity of human serum butyrylcholinesterase: Studies using monoclonal antibodies and characterization of the peptidase
45. Regulation of the rat oligodendroglia cell line OLN-93 by antisense transfection of butyrylcholinesterase
46. Serum acetylcholinesterase possesses trypsin-like and carboxypeptidase B-like activity
47. Non-cholinergic actions of acetylcholinesterases: Proteases regulating cell growth and development?
48. Acetylcholinesterase exhibits trypsin-like and metalloexopeptidase-like activity in cleaving a model peptide
49. Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's disease
50. A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease
51. A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site
52. "Nonspecific" cholinesterase and acetylcholinesterase in rat tissues: Molecular forms, structural and catalytic properties, and significance of the two enzyme systems
53. Butyrylcholinesterase is complexed with transferrin in chicken serum
54. Neuroglial cholinesterases in the normal brain and in Alzheimer's disease: Relationship to plaques, tangles, and patterns of selective vulnerability
55. cDNA cloning and expression of a novel serine protease, TLSP