Haemorrhage-evoked compensation and decompensation are mediated by distinct caudal midline medullary regions in the urethane-anaesthetised rat

Neuroscience

Volumn 113, Issue 3, 2002, Pages 555-567

  Heslop, D J ^a   Keay, K A ^a,b   Bandler, R ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Anaesthesia; Arterial pressure; Blood loss; Bradycardia; Hypertension; Hypotension; Hypovolaemia; Raphe nuclei; Shock

Indexed keywords

HALOTHANE; LIDOCAINE; URETHAN; EXCITATORY AMINO ACID; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; LOCAL ANESTHETIC AGENT;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VOLUME; BRADYCARDIA; BRAIN HEMORRHAGE; BRAIN REGION; CONTROLLED STUDY; GLOBUS PALLIDUS; HYPOTENSION; MALE; NERVE CELL; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SPINAL CORD; ADRENERGIC SYSTEM; ANIMAL; BLEEDING; DRUG EFFECT; HEART RATE; MEDULLA OBLONGATA; MICROINJECTION; PATHOPHYSIOLOGY; PRESSORECEPTOR; SPRAGUE DAWLEY RAT;

ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; ANESTHETICS, LOCAL; ANIMAL; BLOOD PRESSURE; EXCITATORY AMINO ACIDS; HALOTHANE; HEART RATE; HEMORRHAGE; HYPOTENSION; LIDOCAINE; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; PRESSORECEPTORS; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SYMPATHETIC NERVOUS SYSTEM; URETHANE; ANIMALS;

EID: 0037008869     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00161-6     Document Type: Article

References (58)

1. Pressor effects elicited by stimulation within the medullary raphe nuclei of the guinea pig (Cavia porcellus)
2. Electron microscopic evidence of a monosynaptic pathway between cells in the caudal raphe nuclei and sympathetic preganglionic rat spinal cord
3. Distribution of hypothalamic, medullary and lamina terminalis neurons expressing Fos after hemorrhage in conscious rats
4. Differential time- and dose-related effects of haemorrhage on tyrosine hydroxylase and neuropeptide Y mRNA expression in medullary catecholamine neurons
5. Powerful depressor and sympathoinhibitory effects evoked from neurons in the caudal raphe pallidus and obscurus
6. Sympathoinhibition evoked from caudal midline medulla is mediated by GABA receptors in rostral VLM
7. Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat
8. Functional organization of central pathways regulating the cardiovascular system
9. Glutamate stimulation of raphe pallidus attenuates the cardiopulmonary reflex in anaesthetised rats
10. A CNS serotonergic mechanism in acute central hypovolemia in conscious rabbits?
11. Pressor effects elicited by stimulation within the medullary raphe nuclei of the golden hamster (Mesocricetus auratus)
12. The central organization of carotid body afferent projections to the brainstem of the rat
13. Inhibition of sympathetic activity by stimulating in the raphe nuclei and the role of 5-hydroxytryptamine in this effect
14. The ventrolateral periaqueductal gray projects to caudal brainstem depressor regions: A functional-anatomical and physiological study
15. Hypotension following acute hypovolaemia depends on the caudal midline medulla
16. Caudal midline medulla mediates behaviourally-coupled but not baroreceptor-mediated vasodepression
17. Medullary raphe: A new site for vagally mediated stimulation of gastric motility in cats
18. Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion
19. Immunohistochemical evidence for the coexistence of substance P, thyrotropin-releasing hormone, GABA, methionine-enkephalin, and leucine-enkephalin in the serotonergic neurons of the caudal raphe nuclei: A dual labeling in the rat
20. Brainstem projections of sensory and motor components of the vagus nerve in the rat
21. The neuroanatomy of cardiac nociceptive pathways - Differential representations of 'deep' and 'superficial' pain
22. The caudal midline medulla mediates state dependent cardiovascular responses
23. Presynaptic and postsynaptic actions of halothane at glutamatergic synapses in the mouse hippocampus
24. Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat
25. Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat
26. Haemorrhage and shock
27. Naloxone and haemorrhagic hypotension in rats. Evidence against sympathetic nervous system as the primary mediator of improved cardiovascular haemodynamics
28. Cardiovascular responses to combined microinjection of substance P and acetylcholine in the intermediolateral nucleus of the rat
29. Afferent sources of substance P in the C1 area of the rat rostral ventrolateral medulla
30. Separate areas of rat medulla oblongata with populations of serotonin- and adrenaline-containing neurons alter blood pressure after L-glutamate stimulation
31. Raphe pallidus excites a unique class of sympathetic preganglionic neurons
32. Afferent connections of the caudal raphe pallidus nucleus in rats: A study using the fluorescent retrograde tracers fluorogold and true blue
33. Distribution of neuroactive substances in the dorsal vagal complex of the medulla oblongata
34. Mechanism of action of volatile anesthetics: Effects of halothane on glutamate receptors in vitro
35. Halothane blocks synaptic excitation of inhibitory interneurons
36. Spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection
37. Spinal afferents to the vasodepressor region of the caudal midline medulla in rat
38. The C1 area of rostral ventrolateral medulla: A central site integrating autonomic responses to hemorrhage
39. The use of local anaesthetic microinjections to identify central pathways: A quantitative evaluation of the timecourse and extent of the neuronal block
40. Central connections of the sensory and motor nuclei of the vagus nerve
41. Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals
42. Neurones in the medullary raphe nuclei attenuate the cardiovascular responses evoked from the dorsolateral periaqueductal grey matter
43. The renal vascular response to mild and severe haemorrhage in the anaesthetized rat
44. Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat
45. Changes in renal sympathetic outflow during hypotensive haemorrhage in rats
46. A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infections
47. CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus
48. Vagal regulation of gastric function involves thyrotropin-releasing hormone in the medullary raphe nuclei and dorsal vagal complex
49. Caudal raphe - Dorsal vagal complex peptidergic projections: Role in gastric vagal control
50. Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex
51. Serotonin and substance P, colocalisation in medullary projections to the nucleus tractus solitarius: Dual colour immunohistochemistry combined with retrograde tracing
52. The carotid sinus connections: A WGA-HRP study in the cat
53. Effects of halothane, ketamine, propofol and alfentanial anaesthesia on circulatory control in rabbits
54. Midline medullary depressor responses are mediated by inhibition of RVLM sympathoexcitatory neurons in rats
55. Differential control of adrenal and renal sympathetic nerve activity during hemorrhagic hypotension in rats
56. Control of phrenic nerve activity and blood pressure by the medullary raphe nuclei in cats
57. Differential actions of the medial region of caudal medulla on autonomic nerve activities