Prolonged treatment with prostaglandin E1 increases the rate of lipolysis in rat adipocytes

Life Sciences

Volumn 73, Issue 4, 2003, Pages 393-401

  Freeth, Amy ^a   Udupi, Vidya ^b   Basile, Robin ^b   Green, Allan ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b BASSETT RESEARCH INSTITUTE   (United States)

Author keywords

Adenosine; Free fatty acids; G proteins; Insulin resistance; Lipolysis; TNF

Indexed keywords

NICOTINIC ACID; PHENYLISOPROPYLADENOSINE; PROSTAGLANDIN E1; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; HYPOTHESIS; INCUBATION TIME; LIPOLYSIS; MALE; NONHUMAN; RAT; STIMULATION;

EID: 0038297136     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00313-8     Document Type: Article

References (26)

1. Bergman R.N., Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends in Endocrinology and Metabolism. 11:2000;351-356.
2. Bergman R.N., Mittelman S.D. Central role of the adipocyte in insulin resistance. Journal of Basic and Clinical Physiology and Pharmacology. 9:1998;205-221.
3. Botion L.M., Brasier A.R., Tian B., Udupi V., Green A. Inhibition of proteasome activity blocks the ability of TNFα to down-regulate Gi proteins and stimulate lipolysis. Endocrinology. 142:2001;5069-5075.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Analytical Biochemistry. 72:1976;248-254.
5. i2 in rat adipocytes. Biochemical Journal. 297:1994;41-45.
6. Doris R.A., Kilgour E., Houslay M.D., Vernon R.G. Regulation of the GTP-binding protein-based antilipolytic system of sheep adipocytes by growth hormone. Journal of Endocrinology. 158:1998;295-303.
7. 2 agonist, UK 14304. Biochemical Pharmacology. 49:1995;785-790.
8. i protein concentrations. Journal of Biological Chemistry. 274:1999;6770-6775.
9. Green A., Dobias S.B., Walters D.J.A., Brasier A.R. Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase. Endocrinology. 134:1994;2581-2588.
10. Green A., Johnson J.L., Milligan G. Down-regulation of Gi sub-types by prolonged incubation of adipocytes with an A1 adenosine receptor agonist. Journal of Biological Chemistry. 265:1990;5206-5210.
11. Green A., Milligan G., Dobias S.B. Gi down-regulation as a mechanism for heterologous desensitization in adipocytes. Journal of Biological Chemistry. 267:1992;3223-3229.
12. i subtypes. American Journal of Physiology. 273:1997;E254-E261.
13. Greenberg A.S., Egan J.J., Wek S.A., Garty N.B., Blanchette-Mackie E.J., Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. Journal of Biological Chemistry. 266:1991;11341-11346.
14. Holm C., Osterlund T., Laurell H., Contreras J.A. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Annual Review of Nutrition. 20:2000;365-393.
15. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
16. Large V., Arner P. Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia. Diabetes and Metabolism. 24:1998;409-418.
17. Manganiello V.C., Degerman E., Smith C.J., Vasta V., Tornqvist H., Belfrage P. Mechanisms for activation of the rat adipocyte particulate cyclic-GMP-inhibited cyclic AMP phosphodiesterase and its importance in the antilipolytic action of insulin. Advances in Second Messenger and Phosphoprotein Research. 25:1992;147-164.
18. Marshall S., Garvey W.T., Geller M. Primary culture of isolated adipocytes: a new model to study insulin receptor regulation and insulin action. Journal of Biological Chemistry. 259:1984;6376-6384.
19. McGowan M.W., Artiss J.D., Strandbergh D.R., Zak B. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clinical Chemistry. 29:1983;538-543.
20. Rodbell M. Metabolism of isolated fat cells: I. Effects of hormones on glucose metabolism and lipolysis. Journal of Biological Chemistry. 239:1964;375-380.
21. Ruderman N., Chisholm D., Pi-Sunyer F.X., Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes. 47:1998;699-713.
22. Shuldiner A.R., Yang R.Z., Gong D.W. Resistin, obesity, and insulin resistance - the emerging role of the adipocyte as an endocrine organ. New England Journal of Medicine. 345:2001;1345-1346.
23. Souza S.C., De Vargas L.M., Yamamoto M.T., Lien P., Franciosa M.D., Moss L.G., Greenberg A.S. Overexpression of perilipin A and B blocks the ability of tumor necrosis factor α to increase lipolysis in 3T3-L1 adipocytes. Journal of Biological Chemistry. 273:1998;24665-24669.
24. Syu L.J., Saltiel A.R. Lipotransin: A novel docking protein for hormone-sensitive lipase. Molecular Cell. 4:1999;109-115.
25. Yip R.G., Goodman H.M. Growth hormone and dexamethasone stimulate lipolysis and activate adenylyl cyclase in rat adipocytes by selectively shifting Gi alpha2 to lower density membrane fractions. Endocrinology. 140:1999;1219-1227.
26. Zhang H.H., Halbleib M., Ahmad F., Manganiello V.C., Greenberg A.S. Tumor Necrosis Factor-alpha Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of Intracellular cAMP. Diabetes. 51:2002;2929-2935.