메뉴 건너뛰기




Volumn 24, Issue 2, 2003, Pages 123-133

Oxidative cochlear injury and the limitations of antioxidant therapy

Author keywords

Antioxidants; Cochlea; Free radicals; Mitochondria; Noise induced hearing loss; Ototoxicants; Reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; OXYGEN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

EID: 0038284631     PISSN: 07340451     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-39839     Document Type: Conference Paper
Times cited : (5)

References (67)
  • 1
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem 1992;59:1609-1623
    • (1992) J Neurochem , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 2
    • 0027937548 scopus 로고
    • Oxidative stress: Free radicals production in neural degeneration
    • Götz ME, Kunig G, Riederer P, Youdim MBH. Oxidative stress: free radicals production in neural degeneration. Pharm Ther 1994;63:37-122
    • (1994) Pharm Ther , vol.63 , pp. 37-122
    • Götz, M.E.1    Kunig, G.2    Riederer, P.3    Youdim, M.B.H.4
  • 3
    • 0028170326 scopus 로고
    • Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress
    • Michiels C, Raes M, Toussaint O, Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med 1994;17:235-248
    • (1994) Free Radic Biol Med , vol.17 , pp. 235-248
    • Michiels, C.1    Raes, M.2    Toussaint, O.3    Remacle, J.4
  • 4
    • 0033046052 scopus 로고    scopus 로고
    • Signal transduction by reactive oxygen species in non-phagocytic cells
    • Finkel T. Signal transduction by reactive oxygen species in non-phagocytic cells. J Leukoc Biol 1999;65:337-340
    • (1999) J Leukoc Biol , vol.65 , pp. 337-340
    • Finkel, T.1
  • 5
    • 0001952829 scopus 로고    scopus 로고
    • Redox signaling: Hydrogen peroxide as intracellular messenger
    • Rhee SG. Redox signaling: Hydrogen peroxide as intracellular messenger. Exp Mol Med 1999;31:53-59
    • (1999) Exp Mol Med , vol.31 , pp. 53-59
    • Rhee, S.G.1
  • 6
    • 0035371184 scopus 로고    scopus 로고
    • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    • Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001;30:1191-1212
    • (2001) Free Radic Biol Med , vol.30 , pp. 1191-1212
    • Schafer, F.Q.1    Buettner, G.R.2
  • 7
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995;38:357-366
    • (1995) Ann Neurol , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 8
    • 0024412660 scopus 로고
    • Photo-induced irreversible shortening and swelling of isolated cochlear outer hair cells
    • Dulon D, Zajic G, Schacht J. Photo-induced irreversible shortening and swelling of isolated cochlear outer hair cells. Int J Radiat Biol 1989;55:1007-1014
    • (1989) Int J Radiat Biol , vol.55 , pp. 1007-1014
    • Dulon, D.1    Zajic, G.2    Schacht, J.3
  • 9
    • 0027409215 scopus 로고
    • Effects of free radicals on the intracellular Calcium concentration in the isolated outer hair cell of the guinea pig cochlea
    • Ikeda K, Sunose H, Takasaka T. Effects of free radicals on the intracellular Calcium concentration in the isolated outer hair cell of the guinea pig cochlea. Acta Otolaryngol 1993;113:137-141
    • (1993) Acta Otolaryngol , vol.113 , pp. 137-141
    • Ikeda, K.1    Sunose, H.2    Takasaka, T.3
  • 10
    • 0025750848 scopus 로고
    • The protective effects of tirilated mesylate (U74006F) on ischemic and reperfusion-induced cochlear damage
    • Seidman MD, Quirk WS. The protective effects of tirilated mesylate (U74006F) on ischemic and reperfusion-induced cochlear damage. Otolaryngol Head Neck Surg 1991;105:511-516
    • (1991) Otolaryngol Head Neck Surg , vol.105 , pp. 511-516
    • Seidman, M.D.1    Quirk, W.S.2
  • 11
    • 0025837268 scopus 로고
    • The protective effects of allopurinol and superoxide dismutase-polyethylene glycol on ischemic and reperfusion-induced cochlear damage
    • Seidman MD, Quirk WS, Nuttall AL, Schweintzer VG. The protective effects of allopurinol and superoxide dismutase-polyethylene glycol on ischemic and reperfusion-induced cochlear damage. Otolaryngol Head Neck Surg 1991;105:457-463
    • (1991) Otolaryngol Head Neck Surg , vol.105 , pp. 457-463
    • Seidman, M.D.1    Quirk, W.S.2    Nuttall, A.L.3    Schweintzer, V.G.4
  • 12
    • 0028260467 scopus 로고
    • Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo
    • Garetz SL, Altschuler RA, Schacht J. Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear Res 1994;77:81-87
    • (1994) Hear Res , vol.77 , pp. 81-87
    • Garetz, S.L.1    Altschuler, R.A.2    Schacht, J.3
  • 13
    • 0028358176 scopus 로고
    • Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro
    • Garetz SL, Rhee DJ, Schacht J. Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hear Res 1994;77:75-80
    • (1994) Hear Res , vol.77 , pp. 75-80
    • Garetz, S.L.1    Rhee, D.J.2    Schacht, J.3
  • 14
    • 0028206544 scopus 로고
    • Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts
    • Quirk WS, Shivapuja BG, Schwimmer CL, Seidman MD. Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts. Hear Res 1994;74:217-220
    • (1994) Hear Res , vol.74 , pp. 217-220
    • Quirk, W.S.1    Shivapuja, B.G.2    Schwimmer, C.L.3    Seidman, M.D.4
  • 15
    • 0030561543 scopus 로고    scopus 로고
    • D-methionine provides excellent protection from cisplatin ototoxicity in the rat
    • Campbell KCM, Rybak LP, Meech RP, Hughes L. D-methionine provides excellent protection from cisplatin ototoxicity in the rat. Hear Res 1996;102:90-98
    • (1996) Hear Res , vol.102 , pp. 90-98
    • Campbell, K.C.M.1    Rybak, L.P.2    Meech, R.P.3    Hughes, L.4
  • 16
    • 0030026740 scopus 로고    scopus 로고
    • Effects of superoxide dismutase and U74389G on acute trimethylin-induced cochlear dysfunction
    • Clerici WJ. Effects of superoxide dismutase and U74389G on acute trimethylin-induced cochlear dysfunction. Toxicol Appl Pharmacol 1996;136:236-242
    • (1996) Toxicol Appl Pharmacol , vol.136 , pp. 236-242
    • Clerici, W.J.1
  • 17
    • 0001561521 scopus 로고    scopus 로고
    • The protective effects of R-PIA on noise-induced hearing loss
    • Hu BH, Zheng XY, McFadden S, Henderson D. The protective effects of R-PIA on noise-induced hearing loss. Hear Res 1997;113:198-206
    • (1997) Hear Res , vol.113 , pp. 198-206
    • Hu, B.H.1    Zheng, X.Y.2    McFadden, S.3    Henderson, D.4
  • 18
    • 0032938438 scopus 로고    scopus 로고
    • Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: Antioxidant defense system
    • Rybak LP, Husain K, Whitworth C, Somani SM. Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system. Toxicol Sci 1999;47:195-202
    • (1999) Toxicol Sci , vol.47 , pp. 195-202
    • Rybak, L.P.1    Husain, K.2    Whitworth, C.3    Somani, S.M.4
  • 19
    • 0033537264 scopus 로고    scopus 로고
    • Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line derived neurotrophic factor in vivo
    • Yamasoba T, Schacht J, Shoji F, Miller JM. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line derived neurotrophic factor in vivo. Brain Res 1999;815:317-325
    • (1999) Brain Res , vol.815 , pp. 317-325
    • Yamasoba, T.1    Schacht, J.2    Shoji, F.3    Miller, J.M.4
  • 20
    • 0033805864 scopus 로고    scopus 로고
    • Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla
    • Kopke RD, Weisskopf PA, Boone JL, et al. Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla. Hear Res 2000;149:138-146
    • (2000) Hear Res , vol.149 , pp. 138-146
    • Kopke, R.D.1    Weisskopf, P.A.2    Boone, J.L.3
  • 21
    • 0034022331 scopus 로고    scopus 로고
    • Antioxidants attenuate gentamicin-induced free radical formation in vivo: Dmethionine is a potential protectant
    • Sha S, Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vivo: Dmethionine is a potential protectant. Hear Res 2000; 142:34-40
    • (2000) Hear Res , vol.142 , pp. 34-40
    • Sha, S.1    Schacht, J.2
  • 22
    • 0029618724 scopus 로고
    • Appearance of free radicals in the guinea pig Inner ear after noise-induced acoustic trauma
    • Yamane H, Nakai Y, Takayama M, et al. Appearance of free radicals in the guinea pig Inner ear after noise-induced acoustic trauma. Eur Arch Otorhinolaryngol 1995;252:504-508
    • (1995) Eur Arch Otorhinolaryngol , vol.252 , pp. 504-508
    • Yamane, H.1    Nakai, Y.2    Takayama, M.3
  • 23
    • 0030248516 scopus 로고    scopus 로고
    • Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants
    • Clerici WJ, Hensley K, DiMartino DL, Butterfield DA. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 1996;98:116-124
    • (1996) Hear Res , vol.98 , pp. 116-124
    • Clerici, W.J.1    Hensley, K.2    DiMartino, D.L.3    Butterfield, D.A.4
  • 24
    • 0031081406 scopus 로고    scopus 로고
    • Reactive oxygen species in chick hair cells after gentamicin exposure in vitro
    • Hirose K, Hockenbery DM, Rubel EW. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 1997;104:1-14
    • (1997) Hear Res , vol.104 , pp. 1-14
    • Hirose, K.1    Hockenbery, D.M.2    Rubel, E.W.3
  • 25
    • 12644293785 scopus 로고    scopus 로고
    • Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells
    • Kopke RD, Liu W, Gabaizedah R, et al. Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am J Otol 1997;18:559-571
    • (1997) Am J Otol , vol.18 , pp. 559-571
    • Kopke, R.D.1    Liu, W.2    Gabaizedah, R.3
  • 26
    • 0032789858 scopus 로고    scopus 로고
    • Elevation of reactive oxygen species following ischemia-reperfusion in mouse cochlea observed in vivo
    • Ohlemiller KK, Dugan LL. Elevation of reactive oxygen species following ischemia-reperfusion in mouse cochlea observed in vivo. Audiol Neurootol 1999;4:219-228
    • (1999) Audiol Neurootol , vol.4 , pp. 219-228
    • Ohlemiller, K.K.1    Dugan, L.L.2
  • 27
    • 0032810709 scopus 로고    scopus 로고
    • Early elevation of cochlear reactive oxygen species following noise exposure
    • Ohlemiller KK, Wright JS, Dugan LL. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 1999;4:229-236
    • (1999) Audiol Neurootol , vol.4 , pp. 229-236
    • Ohlemiller, K.K.1    Wright, J.S.2    Dugan, L.L.3
  • 28
    • 0034029104 scopus 로고    scopus 로고
    • Hydroxyl radical formation in the perilymph of asphyxic guinea pig
    • Hara A, Serizawa F, Tabuchi K, Senarita M, Kusakari J. Hydroxyl radical formation in the perilymph of asphyxic guinea pig. Hear Res 2000;143:110-114
    • (2000) Hear Res , vol.143 , pp. 110-114
    • Hara, A.1    Serizawa, F.2    Tabuchi, K.3    Senarita, M.4    Kusakari, J.5
  • 29
    • 0030297554 scopus 로고    scopus 로고
    • Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function
    • Clerici WJ, Yang L. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res 1996;101:14-22
    • (1996) Hear Res , vol.101 , pp. 14-22
    • Clerici, W.J.1    Yang, L.2
  • 30
    • 0034730545 scopus 로고    scopus 로고
    • Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea
    • Ohinata Y, Miller JM, Altschuler RA, Schacht J. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Res 2000;878:163-173
    • (2000) Brain Res , vol.878 , pp. 163-173
    • Ohinata, Y.1    Miller, J.M.2    Altschuler, R.A.3    Schacht, J.4
  • 31
    • 0031895404 scopus 로고    scopus 로고
    • Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla
    • Jacono AA, Hu B, Kopke RD, et al. Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 1998;117:31-38
    • (1998) Hear Res , vol.117 , pp. 31-38
    • Jacono, A.A.1    Hu, B.2    Kopke, R.D.3
  • 32
    • 0032584953 scopus 로고    scopus 로고
    • Influence of intense sound exposure on glutathione synthesis in the cochlea
    • Yamasoba T, Harris C, Shoji F, et al. Influence of intense sound exposure on glutathione synthesis in the cochlea. Brain Res 1998;804:72-78
    • (1998) Brain Res , vol.804 , pp. 72-78
    • Yamasoba, T.1    Harris, C.2    Shoji, F.3
  • 35
    • 0027392717 scopus 로고
    • Genetics of age-related hearing loss in mice. I. Inbred and F1 hybrid strains
    • Erway LC, Willott JF, Archer JR, Harrison DE. Genetics of age-related hearing loss in mice. I. Inbred and F1 hybrid strains. Hear Res 1993;65:125-132
    • (1993) Hear Res , vol.65 , pp. 125-132
    • Erway, L.C.1    Willott, J.F.2    Archer, J.R.3    Harrison, D.E.4
  • 36
    • 0029975313 scopus 로고    scopus 로고
    • Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noiseinduced hearing loss
    • Erway LC, Shiau Y-W, Davis RR, Kreig EF. Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noiseinduced hearing loss. Hear Res 1996;93:181-187
    • (1996) Hear Res , vol.93 , pp. 181-187
    • Erway, L.C.1    Shiau, Y.-W.2    Davis, R.R.3    Kreig, E.F.4
  • 38
    • 0033796186 scopus 로고    scopus 로고
    • Vulnerability to noise-induced hearing loss in 'middleaged' and young adult mice: A dose-response approach in CBA, C57BL, and BALB inbred strains
    • Ohlemiller KK, Wright JS, Heidbreder AF. Vulnerability to noise-induced hearing loss in 'middleaged' and young adult mice: A dose-response approach in CBA, C57BL, and BALB inbred strains. Hear Res 2000;149:239-247
    • (2000) Hear Res , vol.149 , pp. 239-247
    • Ohlemiller, K.K.1    Wright, J.S.2    Heidbreder, A.F.3
  • 40
    • 0033547189 scopus 로고    scopus 로고
    • Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice
    • McFadden SL, Ding D, Burkard RF, et al. Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice. J Comp Neurol 1999;413:101-112
    • (1999) J Comp Neurol , vol.413 , pp. 101-112
    • McFadden, S.L.1    Ding, D.2    Burkard, R.F.3
  • 41
    • 0032813103 scopus 로고    scopus 로고
    • Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase
    • McFadden SL, Ding D, Reaume AG, Flood DG, Salvi RJ. Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol Aging 1999;20:1-8
    • (1999) Neurobiol Aging , vol.20 , pp. 1-8
    • McFadden, S.L.1    Ding, D.2    Reaume, A.G.3    Flood, D.G.4    Salvi, R.J.5
  • 42
    • 0032767363 scopus 로고    scopus 로고
    • Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (SOD1) increases susceptibility to noise-induced hearing loss
    • Ohlemiller KK, McFadden SL, Ding D-L, et al. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (SOD1) increases susceptibility to noise-induced hearing loss. Audiol Neurootol 1999; 4:237-246
    • (1999) Audiol Neurootol , vol.4 , pp. 237-246
    • Ohlemiller, K.K.1    McFadden, S.L.2    Ding, D.-L.3
  • 43
    • 0034450206 scopus 로고    scopus 로고
    • Targeted mutation of the gene for cellular glutathione peroxidase (Gpxl) increases noise-induced hearing loss in mice
    • Ohlemiller KK, McFadden SL, Ding D-L, Lear PM, Ho Y-S. Targeted mutation of the gene for cellular glutathione peroxidase (Gpxl) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol 2000;1:243-254
    • (2000) J Assoc Res Otolaryngol , vol.1 , pp. 243-254
    • Ohlemiller, K.K.1    McFadden, S.L.2    Ding, D.-L.3    Lear, P.M.4    Ho, Y.-S.5
  • 45
    • 0032764049 scopus 로고    scopus 로고
    • Free radicals and hearing: Cause, consequence and criteria
    • Evans P, Halliwell B. Free radicals and hearing: cause, consequence and criteria. Ann N Y Acad Sci 1999;884:19-40
    • (1999) Ann N Y Acad Sci , vol.884 , pp. 19-40
    • Evans, P.1    Halliwell, B.2
  • 46
    • 0032787487 scopus 로고    scopus 로고
    • A radical demise: Toxins and trauma share common pathways in hair cell death
    • Kopke R, Allen KA, Henderson D, et al. A radical demise: toxins and trauma share common pathways in hair cell death. Ann N Y Acad Sci 1999;884:171-191
    • (1999) Ann N Y Acad Sci , vol.884 , pp. 171-191
    • Kopke, R.1    Allen, K.A.2    Henderson, D.3
  • 47
    • 0022439252 scopus 로고
    • Overview of mechanical damage to the inner ear: Noise as a tool to probe cochlear function
    • Slepecky N. Overview of mechanical damage to the inner ear: noise as a tool to probe cochlear function. Hear Res 1986;22:307-321
    • (1986) Hear Res , vol.22 , pp. 307-321
    • Slepecky, N.1
  • 48
    • 0025884687 scopus 로고
    • The structural and functional consequences of acoustic injury in the cochlea and peripheral auditory system
    • Saunders JC, Cohen YE, Szymko YM. The structural and functional consequences of acoustic injury in the cochlea and peripheral auditory system. J Acoust Soc Am 1991;90:136-146
    • (1991) J Acoust Soc Am , vol.90 , pp. 136-146
    • Saunders, J.C.1    Cohen, Y.E.2    Szymko, Y.M.3
  • 50
    • 0032733811 scopus 로고    scopus 로고
    • L- and Dmethionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro retention of antineoplastic activity
    • Reser D, Rho M, Dewan D, et al. L- and Dmethionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro retention of antineoplastic activity. Neurotoxicology 1999;20:731-748
    • (1999) Neurotoxicology , vol.20 , pp. 731-748
    • Reser, D.1    Rho, M.2    Dewan, D.3
  • 51
    • 17344385626 scopus 로고    scopus 로고
    • Oxidative stress-induced apoptosis of cochlear sensory cells: Otoprotective strategies
    • Huang T, Cheng AG, Stupak H, et al. Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. Int J Dev Neurosci 2000; 18:259-270
    • (2000) Int J Dev Neurosci , vol.18 , pp. 259-270
    • Huang, T.1    Cheng, A.G.2    Stupak, H.3
  • 52
    • 0014645053 scopus 로고
    • Patterns of hair cell damage after intense noise stimulation
    • Stockwell CW, Ades H, Engstrom H. Patterns of hair cell damage after intense noise stimulation. Ann Otol 1969;78:1144-1168
    • (1969) Ann Otol , vol.78 , pp. 1144-1168
    • Stockwell, C.W.1    Ades, H.2    Engstrom, H.3
  • 53
    • 0038449214 scopus 로고    scopus 로고
    • Moderate noise-induced TTSs correlate best with injury to supporting cells rather than hair cells
    • Martinez CS, Bohne BA, Harding GW. Moderate noise-induced TTSs correlate best with injury to supporting cells rather than hair cells. Abstr Assoc Res Otolaryngol 2000;23:44
    • (2000) Abstr Assoc Res Otolaryngol , vol.23 , pp. 44
    • Martinez, C.S.1    Bohne, B.A.2    Harding, G.W.3
  • 54
    • 0029845577 scopus 로고    scopus 로고
    • Signal transduction pathways in apoptosis
    • McConkey DJ, Orrenius S. Signal transduction pathways in apoptosis. Stem Cells 1996;14:619-631
    • (1996) Stem Cells , vol.14 , pp. 619-631
    • McConkey, D.J.1    Orrenius, S.2
  • 55
    • 0343527349 scopus 로고    scopus 로고
    • Connexins, hearing and deafness: Clinical aspects of mutations in the connexin 26 gene
    • Lefebvre PP, Van De Water T. Connexins, hearing and deafness: clinical aspects of mutations in the connexin 26 gene. Brain Res Rev 2000;32:159-162
    • (2000) Brain Res Rev , vol.32 , pp. 159-162
    • Lefebvre, P.P.1    Van De Water, T.2
  • 56
    • 0032757370 scopus 로고    scopus 로고
    • Inhibition of gap junctional coupling in cochlear supporting cells by gentamicin
    • Todt I, Ngezahayo A, Ernst A, Kolb H-A. Inhibition of gap junctional coupling in cochlear supporting cells by gentamicin. Pflugers Arch 1999;438:865-867
    • (1999) Pflugers Arch , vol.438 , pp. 865-867
    • Todt, I.1    Ngezahayo, A.2    Ernst, A.3    Kolb, H.-A.4
  • 58
    • 0000817537 scopus 로고    scopus 로고
    • Homeostatic mechanisms in the cochlea
    • Dallos P, Popper AN, Fay RD, eds. New York: Springer-Verlag
    • Wangemann P, Schacht J. Homeostatic mechanisms in the cochlea. In: Dallos P, Popper AN, Fay RD, eds. The Cochlea. New York: Springer-Verlag; 1996:130-185
    • (1996) The Cochlea , pp. 130-185
    • Wangemann, P.1    Schacht, J.2
  • 59
    • 0032801851 scopus 로고    scopus 로고
    • Mechanisms of alterations in the microcirculation of the cochlea
    • Seidman MD, Quirk WS, Shirwany NA. Mechanisms of alterations in the microcirculation of the cochlea. Ann N Y Acad Sci 1999;884:226-232
    • (1999) Ann N Y Acad Sci , vol.884 , pp. 226-232
    • Seidman, M.D.1    Quirk, W.S.2    Shirwany, N.A.3
  • 60
    • 0038449258 scopus 로고    scopus 로고
    • Cochlear base-to-apex differences in free radical mechanisms
    • Kettle A, Sha S, Schacht J. Cochlear base-to-apex differences in free radical mechanisms. Abstr Assoc Res Otolaryngol 2001;24:132
    • (2001) Abstr Assoc Res Otolaryngol , vol.24 , pp. 132
    • Kettle, A.1    Sha, S.2    Schacht, J.3
  • 61
    • 0035033342 scopus 로고    scopus 로고
    • Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals
    • Sha S, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001;155:1-8
    • (2001) Hear Res , vol.155 , pp. 1-8
    • Sha, S.1    Taylor, R.2    Forge, A.3    Schacht, J.4
  • 62
    • 0034689579 scopus 로고    scopus 로고
    • Acoustic trauma enhances DNA binding of transcription factor AP1 in the guinea pig inner ear
    • Ogita K, Matsunobu T, Schacht J. Acoustic trauma enhances DNA binding of transcription factor AP1 in the guinea pig inner ear. Neuroreport 2000; 11:859-862
    • (2000) Neuroreport , vol.11 , pp. 859-862
    • Ogita, K.1    Matsunobu, T.2    Schacht, J.3
  • 63
    • 0038449264 scopus 로고    scopus 로고
    • Modulation of cellular AP-1 DNA binding activity by acoustic overstimulation in the guinea pig cochlea
    • Matsunobu T, Ogita K, Osaka H, Schacht J. Modulation of cellular AP-1 DNA binding activity by acoustic overstimulation in the guinea pig cochlea. Abstr Assoc Res Otolaryngol 2001;24:148
    • (2001) Abstr Assoc Res Otolaryngol , vol.24 , pp. 148
    • Matsunobu, T.1    Ogita, K.2    Osaka, H.3    Schacht, J.4
  • 64
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:98-300
    • (1956) J Gerontol , vol.11 , pp. 98-300
    • Harman, D.1
  • 67
    • 0034062312 scopus 로고    scopus 로고
    • Effects of dietary restriction and antioxidants on presbyacusis
    • Seidman MD. Effects of dietary restriction and antioxidants on presbyacusis. Laryngoscope 2000; 110:727-738
    • (2000) Laryngoscope , vol.110 , pp. 727-738
    • Seidman, M.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.