Short-term tests with a pilot sewage plant and biofilm reactors for the biological degradation of the pharmaceutical compounds clofibric acid, ibuprofen, and diclofenac

Science of the Total Environment

Volumn 309, Issue 1-3, 2003, Pages 201-211

  Zwiener, C ^a   Frimmel, F H ^a  

^a UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Biodegradation; Biofilm reactor; Clofibric acid; Diclofenac; Ibuprofen; Model system; Pharmaceutical; Sewage treatment; Waste water

Indexed keywords

ACETONE; BIOFILMS; DRUG PRODUCTS; MICROORGANISMS; MUNICIPAL ENGINEERING; SEWAGE TREATMENT;

BIOFILM REACTORS;

BIODEGRADATION;

ACETONE; ANALGESIC AGENT; ANTILIPEMIC AGENT; CHLOROBENZOIC ACID DERIVATIVE; CLOFIBRIC ACID; DICLOFENAC; IBUPROFEN;

BIODEGRADATION; BIOFILM; BIOREACTOR; PHARMACEUTICAL INDUSTRY; PILOT PLANT; WASTEWATER TREATMENT;

ADAPTATION; ARTICLE; BIODEGRADABILITY; BIODEGRADATION; BIOFILM; BIOFILM REACTOR; CONCENTRATION (PARAMETERS); DRUG DEGRADATION; ELIMINATION REACTION; INTERMETHOD COMPARISON; MICROORGANISM; MODEL; PRIORITY JOURNAL; SEWAGE TREATMENT; SEWAGE TREATMENT PLANT; TIME;

EID: 0038277458     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0048-9697(03)00002-0     Document Type: Article

References (35)

1. Abbas B., Linke I., Kratz W. Erhebung des Verbrauchs von Arzneimittelwirkstoffen im Land Brandenburg. UWSF - Z Umweltchem Ökotox. 13:2001;197-203.
2. Al-Ahmad A., Kümmerer K. Biodegradation of the antineoplastics vindesine, vincristine, and vinblastine and their toxicity against bacteria in the aquatic environment. Cancer Det Prev. 15:2001;102-107.
3. Buser H.-R., Müller M.D., Theobald N. Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and the North Sea. Environ Sci Technol. 32:1998a;188-192.
4. Buser H.-R., Poiger T., Müller M.D. Occurrence and fate of the pharmaceutical drug diclofenac in surface waters: rapid photodegradation in a lake. Environ Sci Technol. 32:1998b;3449-3456.
5. Buser H.-R., Poiger T., Müller M.D. Occurrence and environmental behavior of the chiral pharmaceutical drug ibuprofen in surface waters and in waste water. Environ Sci Technol. 33:1999;2529-2535.
6. Halling-Sørensen B., Nielsen S.N., Lanzky P.F., Ingerslev F., Lützhøft H.C.H., Jörgensen S.E. Occurrence, fate and effects of pharmaceutical substances in the environment - a review. Chemosphere. 36:1998;357-393.
7. Heberer T., Stan H.-J. Pharmaceutical residues in the aquatic system (Arzneimittelrückstände im aquatischen System). Wasser Boden. 50:1998;20-25.
8. Heberer T., Schmidt-Bäumler K., Stan H.-J. Occurrence and distribution of organic contaminants in aquatic system in Berlin. Part I: drug residues and other polar contaminants in Berlin surface and groundwater. Acta Hydrochim Hydrobiol. 26:1998;272-278.
9. Heberer T., Dünnbier U., Reilich C., Stan H.-J. Detection of drugs and drug metabolites in ground water samples of a drinking water treatment plant. Fresenius Environ Bull. 6:1997;438-443.
10. Hesse S., Frimmel F.H. Schnelle Charakterisierung der mikrobiellen Eliminierbarkeit von organischen Wasserinhaltsstoffen mit Hilfe von Biofilm-Reaktoren und Kohlenstoff-/Stickstoff-Detektion. Vom Wasser. 93:1999;1-19.
11. Hirsch R., Ternes T., Haberer K., Kratz K.-L. Occurrence of antibiotics in the aquatic environment. Sci Total Environ. 225:1999;109-118.
12. Ingerslev F., Toräng L., Loke M.-L., Halling Sørensen B., Nyholm N. Primary biodegradation of veterinary antibiotics in aerobic and anaerobic surface water simulation systems. Chemosphere. 44:2001;865-872.
13. Ishizaki A., Michiwaki S., Crabbe E., Kobayashi G., Sonomoto K., Yoshino S. Extractive acetone-butanol-ethanol fermentation using methylated crude palm oil as extractant in batch culture of clostridium saccharoperbutylacetonicum N1-4 (ATCC 13564). J Biosci Bioengin. 87:1999;352-356.
14. Jitesh K., Pangarkar V.G., Niranjan K. Pervaporative stripping of acetone, butanol and ethanol to improve ABE fermentation. Bioseparation. 9:1999;145-154.
15. Kolpin D.A., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environ Sci Technol. 36:2002;1202-1211.
16. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources - a review. Chemosphere. 45:2001;957-967.
17. Kümmerer K, Al-Ahmad A, Wiethan J, Hertle W, Henninger A. Effects and fate of antibiotics in sewage treatment plants. Proceedings of the Third SETAC World Congress, May 21-25, Brighton, UK, 2000a;134.
18. Kümmerer K., Al-Ahmad A., Mersch-Sundermann V. Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test. Chemosphere. 40:2000b;701-710.
19. Möhle E., Kempter C., Kern A., Metzger J.W. Examination of the degradation of drugs in municipal sewage plants using liquid chromatography-electrospray mass spectrometry. Acta Hydrochim Hydrobiol. 27:2000;430-436.
20. Möhle E., Horvath S., Merz W., Metzger J.W. Determination of hardly degradable organic compounds in wastewater - identification of drugs. Vom Wasser. 92:1999;207-223.
21. Montforts M.H.M.M., Kalf D.F., van Vlaardingen P.L.A., Linders J.B.H.J. The exposure assessment of veterinary medicinal products. Sci Total Environ. 225:1999;119-133.
22. Richardson M.L., Bowron J.M. The fate of pharmaceutical chemicals in the aquatic environment. J Pharm Pharmacol. 37:1985;1-12.
23. Sacher F., Lochov E., Bethmann D., Brauch H.-J. Occurrence of drugs in surface waters. Vom Wasser. 90:1998;233-243.
24. Schwabe U, Pfaffrath D. Drug prescribing report ′95 - actual data, costs, trends, and comments. (Arzneimittelverordnungsreport ′95 - Aktuelle Daten, Kosten, Trends und Kommentare), Stuttgart: Gustav Fischer Verlag, 1996.
25. Skoog D.A., West D.M., Holler F.J. Fundamentals in analytical chemistry. 6th ed:1992;665-693 Saunders, Orlando.
26. Stan H.J., Heberer T. Pharmaceuticals in the aquatic environment. Analusis. 25:1997;M20-M23.
27. Standard Guideline EN ISO 9408. Water quality - evaluation of the ultimate aerobic biodegradability of organic compounds in aqueous medium by determination of oxygen demand in a closed respirometer. German standard methods for the examination of water, waste water, and sludge. Weinheim: VCH-Wiley; 2000.
28. Stumpf M., Ternes T.A., Wilken R.-D., Rodrigues S.W., Baumann W. Polar drug residues in sewage and natural waters in the state of Rio de Janeiro, Brazil. Sci Total Environ. 225:1999;135-141.
29. Tang H.-M., Hwang S.-J., Wang W.-C. Degradation of acetone in a biofilter. Environ Engin Sci. 14:1997;219-226.
30. Ternes T.A. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32:1998;3245-3260.
31. Ternes T.A. Pharmaceuticals in surface water. Wasser Boden. 53:2001;9-14.
32. Winkler M., Lawrence J.R., Neu T.R. Selective degradation of ibuprofen and clofibric acid in two model river biofilm systems. Water Res. 35:2001;3197-3205.
33. Zuccato E., Bagnatir R., Fioretti F., Natangeleo M., Calamari D., Fanelli R. Environmental loads and detection of pharmaceuticals in Italy. Kümmerer K. Pharmaceuticals in the environment - sources, fate, effects, and risks. 2001;19-27 Springer, Heidelberg.
34. Zwiener C., Glauner T., Frimmel F.H. Biodegradation of pharmaceutical residues investigated by SPE-GC/ITD-MS and on-line derivatization. J High Resol Chromatogr. 23:2000;474-478.
35. Zwiener C., Seeger S., Glauner T., Frimmel F.H. Metabolites from the biodegradation of pharmaceutical residues of ibuprofen in biofilm reactors and batch experiments. Anal Bioanal Chem. 372:2002;569-575.