The prion peptide forms ion channels in planar lipid bilayers

Cellular and Molecular Biology Letters

Volumn 8, Issue 2, 2003, Pages 353-362

  Berest, Vladimir ^a   Rutkowski, Marcin ^a   Rolka, Krzysztof ^b   Łȩgowska, Anna ^b   Dȩbska, Grazyna ^a   Stȩpkowski, Dariusz ^a   Szewczyk, Adam ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b UNIVERSITY OF GDA SK   (Poland)

Author keywords

Black Lipid Membrane; Ion Channel; Mitochondria; Prion

Indexed keywords

ION CHANNEL; PRION PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHANNEL GATING; HIPPOCAMPUS; LIPID BILAYER; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; PROTEIN AGGREGATION; RAT; SCHIZOAFFECTIVE PSYCHOSIS;

ANIMALIA;

EID: 0038266673     PISSN: 14258153     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Prusiner, S.B., Scott, M.R., DeArmond, S.J. and Cohen, F.E. Prion protein biology. Cell 93 (1998) 337-348.
2. Prusiner, S.B. Prions. Proc. Nat. Acad. Sci. USA 95 (1998) 13363-13383.
3. Brown, D.R. and Besinger, A. Prion protein expression and superoxide dismutase activity Biochem. J. 334 (1998) 423-426.
4. Brown, D.R., Clive, C. and Haswell S.J. Antioxidant activity related to copper binding of native prion protein. J. Neurochem. 76 (2001) 69-76.
5. Kramer, M.L., Kratzin, H.D., Schmidt, B., Romer, A., Windl, O., Liemann, S., Hornemann, S. and Kretzschmar, H. Prion protein binds copper within the physiological concentration range. J. Biol.Chem . 276 (2001) 16711-16719.
6. Chapron, Y., Peyrin, J-M., Crouzy, S., Jaegly, A. and Dormont, D. Theoretical analysis of the implication of PrP in neuronal death during transmissible subacute spongiform encephalopathies: hypothesis of a PrP oligomeric channel. J. Theor. Biol.. 204 (2000) 103-111.
7. Kourie, J.I. and Culverson, A. Prion peptide fragment PrP[106-126] forms distinct cation channel types. J. Neurosci. Res. 62 (2000) 120-133.
8. Chiesa, R. and Harris, D.A. Prion diseases: what is a neurotoxic molecule. Neurobiol. Dis. 8 (2001) 743-763.
9. Kourie, J.I. Prion channel proteins and their role in vacuolation and neurodegenerative diseases. Eur. Biophys. J. 31 (2002) 409-416.
10. Florio, T., Grimaldi, M., Scorziello, A., Salmona, M., Bugiani, O., Tagliavini, F., Forloni, G. and Schettini, G. Intracellular calcium rise through L-type calcium channels, as molecular mechanism for the prion protein fragment 106-126 induced astrioglial proliferation. Biochem. Biophys. Res Commun. 228 (1996) 397-405.
11. Come, J.H., Fraser, P.E. and Lansbury, P.T.Jr. A kinetic model for amyloid formation in the prion disesases: importance of seeding. Proc. Natl. Acad. Sci. USA 90 (1993) 5959-5963.
12. Jarret, J.T. and Lansbury, P.T.Jr. Seeding "one dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimers disease and scrapie. Cell 73 (1993) 1055-1058.
13. Sondheimer, N. and Lindquist, S. Rnql: an epigenetic modifier of protein function in yeast. Mol. Cell. 5 (2000) 163-172.
14. Balbimie, M., Grothe, R. and Eisenberg, D.S. An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta-sheet structure for amyloid. Proc. Nat. Acad. Sci. USA 98 (2001) 2375-2380.
15. Rost, B. and Sander, C. Prediction of protein secondary structure at better than 70% accuracy. J. Mol. Biol. 232 (1993) 584-599.
16. Zahn, R., Liu, A., Riek, R., Von Schroetter, C., Garcia, F.L., Billeter, M., Calzolai, L., Wider, G. and Wutrich, K. NMR solution structure of the human prion protein. Proc. Nat. Acad. Sci. USA 97 (2000) 145-150.
17. O'Donovan, C.N., Tobin, D. and Cotter, T.G. Prion protein fragment PrP(106-126) induces apoptosis via mitochondrial disruption in neuronal SH-SY5Y cells. J. Biol. Chem. 276 (2001) 43516-43523.