Blocking of α5 integrin stimulates production of TGF-β and PAI-1 by human mesangial cells

Biochemical and Biophysical Research Communications

Volumn 305, Issue 4, 2003, Pages 815-819

  Matsumoto, Naoki ^a   Ishimura, Eiji ^a   Koyama, Hidenori ^a   Tanaka, Shinji ^a   Imanishi, Yasuo ^a   Shioi, Atsushi ^a   Inaba, Masaaki ^a   Nishizawa, Yoshiki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Mesangial cell; Plasminogen activator inhibitor 1; Transforming growth factor ; 5 Integrin

Indexed keywords

ALPHA5 INTEGRIN; BETA3 INTEGRIN; FIBRONECTIN RECEPTOR; IMMUNOGLOBULIN G; INTEGRIN RECEPTOR; MATRIX PROTEIN; NEUTRALIZING ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTOR ANTIBODY; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; INHIBITION KINETICS; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION;

EID: 0038242495     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00860-X     Document Type: Article

References (33)

1. Schwartz M.A., Ginsberg M.H. Networks and crosstalk: integrin signalling spreads. Nat. Cell Biol. 4:2002;E65-E68.
2. Plow E.F., Haas T.A., Zhang L., Loftus J., Smith J.W. Ligand binding to integrins. J. Biol. Chem. 275:2000;21785-21788.
3. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell. 110:2002;673-687.
4. Jones J.L., Walker R.A. Integrins: a role as cell signalling molecules. Mol. Pathol. 52:1999;208-213.
5. Liddington R.C., Ginsberg M.H. Integrin activation takes shape. J. Cell Biol. 158:2002;833-839.
6. Watt F.M. Role of integrins in regulating epidermal adhesion, growth and differentiation. Embo J. 21:2002;3919-3926.
7. Wu C., Keivens V.M., O'Toole T.E., McDonald J.A., Ginsberg M.H. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell. 83:1995;715-724.
8. Kagami S., Kuhara T., Yasutomo K., Okada K., Loster K., Reutter W., Kuroda Y. Transforming growth factor-β (TGF-β) stimulates the expression of β1 integrins and adhesion by rat mesangial cells. Exp. Cell Res. 229:1996;1-6.
9. Kagami S., Kondo S., Loster K., Reutter W., Urushihara M., Kitamura A., Kobayashi S., Kuroda Y. Collagen type I modulates the platelet-derived growth factor (PDGF) regulation of the growth and expression of β1 integrins by rat mesangial cells. Biochem. Biophys. Res. Commun. 252:1998;728-732.
10. Border W.A., Noble N.A., Yamamoto T., Tomooka S., Kagami S. Antagonists of transforming growth factor-β: a novel approach to treatment of glomerulonephritis and prevention of glomerulosclerosis. Kidney Int. 41:1992;566-570.
11. Urushihara M., Kagami S., Kuhara T., Tamaki T., Kuroda Y. Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis. Nephrol. Dial. Transplant. 17:2002;1189-1196.
12. Adler S., Brady H.R. Cell adhesion molecules and the glomerulopathies. Am. J. Med. 107:1999;371-386.
13. Gauer S., Yao J., Schoecklmann H.O., Sterzel R.B. Adhesion molecules in the glomerular mesangium. Kidney Int. 51:1997;1447-1453.
14. Jin D.K., Fish A.J., Wayner E.A., Mauer M., Setty S., Tsilibary E., Kim Y. Distribution of integrin subunits in human diabetic kidneys. J. Am. Soc. Nephrol. 7:1996;2636-2645.
15. Kuhara T., Kagami S., Kuroda Y. Expression of beta 1-integrins on activated mesangial cells in human glomerulonephritis. J. Am. Soc. Nephrol. 8:1997;1679-1687.
16. Wayner E.A., Carter W.G., Piotrowicz R.S., Kunicki T.J. The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa. J. Cell Biol. 107:1988;1881-1891.
17. Koyama H., Raines E.W., Bornfeldt K.E., Roberts J.M., Ross R. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell. 87:1996;1069-1078.
18. Marx M., Daniel T.O., Kashgarian M., Madri J.A. Spatial organization of the extracellular matrix modulates the expression of PDGF-receptor subunits in mesangial cells. Kidney Int. 43:1993;1027-1041.
19. Tanaka S., Koyama H., Ichii T., Shioi A., Hosoi M., Raines E.W., Nishizawa Y. Fibrillar collagen regulation of plasminogen activator inhibitor-1 is involved in altered smooth muscle cell migration. Arterioscler. Thromb. Vasc. Biol. 22:2002;1573-1578.
20. Kutz S.M., Hordines J., McKeown-Longo P.J., Higgins P.J. TGF-β1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion. J. Cell Sci. 114:2001;3905-3914.
21. Dalton S.L., Scharf E., Davey G., Assoian R.K. Transforming growth factor-β overrides the adhesion requirement for surface expression of α(5)β(1) integrin in normal rat kidney fibroblasts. A necessary effect for induction of anchorage-independent growth. J. Biol. Chem. 274:1999;30139-30145.
22. Rich S., Van Nood N., Lee H.M. Role of α5β1 integrin in TGF-β 1-costimulated CD8+ T cell growth and apoptosis. J. Immunol. 157:1996;2916-2923.
23. Okuda S., Languino L.R., Ruoslahti E., Border W.A. Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J. Clin. Invest. 86:1990;453-462.
24. Tomooka S., Border W.A., Marshall B.C., Noble N.A. Glomerular matrix accumulation is linked to inhibition of the plasmin protease system. Kidney Int. 42:1992;1462-1469.
25. Baricos W.H., Cortez S.L., Deboisblanc M., Xin S. Transforming growth factor-β is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells. J. Am. Soc. Nephrol. 10:1999;790-795.
26. Schnaper H.W. Balance between matrix synthesis and degradation: a determinant of glomerulosclerosis. Pediatr. Nephrol. 9:1995;104-111.
27. Rerolle J.P., Hertig A., Nguyen G., Sraer J.D., Rondeau E.P. Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis. Kidney Int. 58:2000;1841-1850.
28. Mackay A.R., Corbitt R.H., Hartzler J.L., Thorgeirsson U.P. Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases. Cancer Res. 50:1990;5997-6001.
29. Haraguchi M., Border W.A., Huang Y., Noble N.A. t-PA promotes glomerular plasmin generation and matrix degradation in experimental glomerulonephritis. Kidney Int. 59:2001;2146-2155.
30. Kagami S., Border W.A., Ruoslahti E., Noble N.A. Coordinated expression of beta 1 integrins and transforming growth factor-β-induced matrix proteins in glomerulonephritis. Lab. Invest. 69:1993;68-76.
31. Isono M., Cruz M.C., Chen S., Hong S.W., Ziyadeh F.N. Extracellular signal-regulated kinase mediates stimulation of TGF-β1 and matrix by high glucose in mesangial cells. J. Am. Soc. Nephrol. 11:2000;2222-2230.
32. Kitamura A., Kagami S., Urushihara M., Kondo S., Yoshizumi M., Tamaki T., Kuroda Y. Endothelin-1 is a potent stimulator of α1β1 integrin-mediated collagen matrix remodeling by rat mesangial cells. Biochem. Biophys. Res. Commun. 299:2002;555-561.
33. Kagami S., Urushihara M., Kondo S., Hayashi T., Yamano H., Loster K., Vossmeyer D., Reutter W., Kuroda Y. Effects of anti-α1 integrin subunit antibody on anti-Thy-1 glomerulonephritis. Lab. Invest. 82:2002;1219-1227.