Recruitment of lymphocytes and dendritic cells from the blood to the bronchoalveolar space and the draining lymph nodes after a single intrabronchial application of the lipopeptide MALP-2

Pathobiology

Volumn 70, Issue 5, 2002, Pages 260-265

  Tschernig, Thomas ^a   Luhrmann A ^a   Pabst, R ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Immunostimulation; Leukocytes; Lipopeptide; Lung compartments; MALP 2; Rat

Indexed keywords

IMMUNOSTIMULATING AGENT; LIPOPEPTIDE; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; BLOOD ANALYSIS; CELL COUNT; CONFERENCE PAPER; CONTROLLED STUDY; CYTOLOGY; DENDRITIC CELL; DRUG EFFECT; DRUG INSTILLATION; IMMUNOSTIMULATION; LEUKOCYTE MIGRATION; LUNG BLOOD VESSEL; LUNG INTERSTITIUM; LUNG LAVAGE; LYMPH NODE; LYMPHOCYTE COUNT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM;

ANIMALS; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CELL MOVEMENT; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; INTUBATION, INTRATRACHEAL; LIPOPROTEINS; LUNG; LYMPH NODES; LYMPHOCYTES; MALE; OLIGOPEPTIDES; PULMONARY ALVEOLI; RATS; RATS, INBRED BN; RATS, INBRED LEW; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 0038241609     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070739     Document Type: Conference Paper

References (24)

1. Lührmann A, Deiters U, Skokowa J, Hanke M, Gessner JE, Mühlradt PF, Pabst R, Tschernig T: In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application. Infect Immun 2002;70:3785-3792.
2. Jacobs E: Mycoplasma infections of the human respiratory tract. Wien Klin Wochenschr 1997;109:574-577.
3. Lindsey JR, Cassell H: Experimental Mycoplasma pulmonis infection in pathogen-free mice: Models for studying mycoplasmosis of the respiratory tract. Am J Pathol 1973;72:63-90.
4. Deiters U, Mühlradt PF: Mycoplasmal lipopeptide MALP-2 induces the chemoattractant proteins macrophage inflammatory protein 1alpha (MIP-1alpha), monocyte chemoattractant protein 1, and MIP-2 and promotes leukocyte infiltration in mice. Infect Immun 1999;67:3390-3398.
5. Takeuchi O, Kaufmann A, Grote K, Kawai T, Hoshino K, Morr M, Mühlradt PF, Akira S: Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J Immunol 2000;164:554-557.
6. Takeuchi O, Kawai T, Mühlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S: Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 2001;13:933-940.
7. Baumgarth N, Kelso A: Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection. Eur J Immunol 1996;26:2189-2197.
8. Mühlradt PF, Kiess M, Meyer H, Sussmuth R, Jung G: Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J Exp Med 1997;185:1951-1958.
9. Schuster M, Tschernig T, Krug N, Pabst R: Lymphocytes migrate from the blood into the bronchoalveolar lavage and lung parenchyma in the asthma model of the Brown Norway rat. Am J Respir Crit Care Med 2000;161:558-566.
10. Lambrecht BN, Carro-Muino I, Vermaelen K, Pauwels RA: Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats. Am J Respir Cell Mol Biol 1999;20:1165-1174.
11. Pabst R, Tschernig T: Lymphocyte dynamics: Caution in interpreting BAL numbers. Thorax 1997;52:1078-1080.
12. Westermann J, Puskas Z, Pabst R: Blood transit and recirculation kinetics of lymphocyte subsets in normal rats. Scand J Immunol 1988;28:203-210.
13. Curtis JL, Kim S, Scott PJ, Buechner-Maxwell VA: Adhesion receptor phenotypes of murine lung CD4+ T cells during the pulmonary immune response to sheep erythrocytes. Am J Respir Crit Care Med 1995;12:520-530.
14. Rollins BJ: Chemokines. Blood 1997;90:909-928.
15. Scapini P, Lapinet-Vera JA, Gasperini S, Calzetti F, Bazzoni F, Cassatella MA: The neutrophil as a cellular source of chemokines. Immunol Rev 2000;177:195-203.
16. Schall TJ, Bacon K, Toy KJ, Goeddel DV: Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990;347:669-671.
17. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schroder JM, Wang JM, Howard OM, Oppenheim JJ: Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999;286:525-528.
18. Yang D, Chen Q, Chertov O, Oppenheim JJ: Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J Leukoc Biol 2000;68:9-14.
19. Naot Y, Tully JG, Ginsburg H: Lymphocyte activation by various Mycoplasma strains and species. Infect Immun 1977;18:310-317.
20. Naot Y, Davidson S, Lindenbaum ES: Mitogenicity and pathogenicity of Mycoplasma pulmonis in rats. I. Atypical interstitial pneumonia induced by mitogenic mycoplasmal membranes. J Infect Dis 1981;143:55-62.
21. Lührmann A, Tschernig T, Pabst R: Stimulation of bronchus-associated lymphoid tissue in rats by repeated inhalation of aerosolized lipopeptide MALP-2. Pathobiology 2003;70:262-265.
22. Pabst R, Gehrke I: Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Am J Respir Cell Mol Biol 1990;3:131-135.
23. Tschernig T, Pabst R: Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases. Pathobiology 2000;68:1-8.
24. Rharbaoui F, Drabner B, Borsutzky S, Winckler U, Morr M, Ensoli B, Mühlradt PF, Guzman CA: The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant. Eur J Immunol 2002;32:2857-2865.