Spatial regulation of Gαi protein signaling in clathrin-coated membrane microdomains containing GAIP

Molecular Pharmacology

Volumn 64, Issue 1, 2003, Pages 11-20

  Elenko, Eric ^a   Fischer, Thierry ^a   Niesman, Ingrid ^a   Harding, Tim ^a,b   McQuistan, Tammie ^a   Von Zastrow, Mark ^c   Farquhar, Marilyn G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLATHRIN; DELTA OPIATE RECEPTOR; DYNAMIN; GALPHA INTERACTING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RGS PROTEIN; RGS19 PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; ADAPTOR PROTEIN; BACTERIAL PROTEIN; GNAI3 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOPROTEIN; PHOTOPROTEIN; REGULATOR OF G PROTEIN SIGNALLING 19; REGULATOR OF G-PROTEIN SIGNALLING 19; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ARTICLE; CELL LINE; CELL MEMBRANE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTERNALIZATION; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SECRETORY VESICLE; SIGNAL TRANSDUCTION; CELL CULTURE; CHEMISTRY; COATED VESICLE; ENDOSOME; GENETICS; METABOLISM; PHYSIOLOGY;

ADAPTOR PROTEIN COMPLEX 2; BACTERIAL PROTEINS; CELLS, CULTURED; CLATHRIN; COATED VESICLES; DYNAMINS; ENDOSOMES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; LUMINESCENT PROTEINS; MEMBRANE MICRODOMAINS; PHOSPHOPROTEINS; RECEPTORS, OPIOID, DELTA; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 0038237084     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.1.11     Document Type: Article

References (41)

1. Anderson RGW (1998) The caveolae membrane system. Annu Rev Biochem 67:199-225.
2. Baba T, Ueda H, Terada N, Fujii Y, and Ohno S (1999) Immunocytochemical study of endocytic structures accumulated in HeLa cells transformed with a temperature-sensitive mutant of dynamin. J Histochem Cytochem 47:637-648.
3. Brodsky FM, Chen CY, Knuehl C, Towler MC, and Wakeham DE (2001) Biological basket weaving: formation and function of clathrin-coated vesicles. Annu Rev Cell Dev Biol 17:517-568.
4. Damke H, Baba T, Warnock DE, and Schmid SL (1994) Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J Biol Chem 127:915-934.
5. De Vries L, Bin Z, Fischer T, Elenko E, and Farquhar MG (2000) The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol 40:235-272.
6. De Vries L, Elenko E, Hubler L, Jones TL, and Farquhar MG (1996) GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of Gαi subunits. Proc Natl Acad Sci USA 93:15203-15208.
7. De Vries L, Elenko E, McCaffery JM, Fischer T, Hubler L, McQuistan T, Watson N, and Farquhar MG (1998) RGS-GAIP, a GTPase-activating protein for Gαi heterotrimeric G proteins, is located on clathrin-coated vesicles. Mol Biol Cell 9:1123-1134.
8. De Vries L, Mousli M, Wurmser A, and Farquhar MG (1995) GAIP, a protein that specifically interacts with the trimeric G protein Gαi3, is a member of a protein family with a highly conserved core domain. Proc Natl Acad Sci USA 92:11916-11920.
9. Ferguson SSG (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53:1-24.
10. z. Proc Natl Acad Sci USA 97:1085-1090.
11. Gaidarov I, Santini F, Warren RA, and Keen JH (1999) Spatial control of coated-pit dynamics in living cells. Nat Cell Biol 1:1-7.
12. 2-adrenergic receptor. J Biol Chem 273:6976-6981.
13. Heding A, Vrel M, Hanyalgolu AC, Sellar R, Taylore PL, and Eidne KA (2000) The rat gonadotropin-releasing hormone receptor internalizes via a beta-arrestin independent, but dynamin-dependent, pathway: addition of a carboxyl-terminal tail confers beta-arrestin dependency. Endocrinol 141:299-306.
14. Hinshaw JE (2000) Dynamin and its role in membrane fission. Annu Rev Cell Dev Biol 16:483-519.
15. Huang C, Hepler JR, Chen LT, Gilman AG, Anderson RG, and Mumby SM (1997) Organization of G proteins and adenylyl cyclase at the plasma membrane. Mol Biol Cell 8:2365-2378.
16. q-green fluorescent protein fusion in living cells. J Biol Chem 276:4227-4235.
17. Ikonen E (2001) Roles of lipid rafts in membrane transport. Curr Opin Cell Biol 13:470-477.
18. Jin A and Nossal R (1993) Topological mechanisms involved in the formation of clathrin-coated vesicles. Biophys J 65:1523-1537.
19. Katagiri YU, Mori T, Nakajima MT, Katagiri C, Taguchi T, Takeda T, Kiyokawa N and Fujimoto J (1999) Activation of Src family kinase Yes induced by shiga toxin binding to globotriaosyl ceramide (Gb3/CD77) in low density, detergent-insoluble microdomains. J Biol Chem 274:35278-35282.
20. Keith DE, Murray SR, Zaki PA, Chu PC, Lissini DV, Kang L, Evans CJ, and von Zastrow M (1996) Morphine activates opioid receptors without causing their rapid internalization. J Biol Chem 271:19021-19024.
21. Levis M and Bourne H (1992) Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation and membrane avidity. J Cell Biol 119:1297-1307.
22. Marsh M and McMahon HT (1999) The structural era of endocytosis. Science (Wash DC) 285:215-219.
23. i3 in detergent-resistant complexes from ovary carcinoma cell line IGROV1. J Cell Sci 113:349-357.
24. Moffett S, Brown DA, and Linder ME (2000) Lipid-dependent targeting of G proteins into rafts. J Biol Chem 275:2191-2198.
25. Mu FT, Callaghan JM, Steele-Mortimer O, Stenmark H, Parton RG, Campbell PL, McCluskey J, Yeo JP, Tock EP, and Toh BH (1995) EEA1, an early endosome-associated protein. EEA1 is a conserved α-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J Biol Chem 270:13503-13511.
26. Murray SR, Evans CJ, and von Zastrow M (1998) Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor. J Biol Chem 273:24987-24991.
27. Neubig RR (1994) Membrane organization in G-protein mechanisms. Faseb J 8:939-946.
28. Rodal SK, Skretting G, Garred O, Vilhardt F, Deurs B, and Sandvig K (1999) Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell 10:961-974.
29. Ross EM and Wilkie TM (2000) GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69:795-827.
30. Shaul PW and Anderson RG (1998) Role of plasmalemmal caveolae in signal transduction. Am J Physiol 275:L843-L851.
31. Shogomori H and Futerman AH (2001) Cholera toxin is found in detergent-insoluble rafts/domains at the cell surface of hippocampal neurons but is internalized via a raft-independent mechanism. J Biol Chem 276:9182-9188.
32. Simons K and Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-41.
33. Steinberg SF and Brunton LL (2001) Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol 41:751-773.
34. Subtil A, Gaidarov I, Kobylarz K, Lampson MA, Keen JH, and McGraw TE (1999) Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc Natl Acad Sci USA 96:6775-6780.
35. Tsao PI and von Zastrow M (2000) Type-specific sorting of G protein-coupled receptors after endocytosis. J Biol Chem 275:1130-1140.
36. Tsao PI and von Zastrow M (2001) Diversity and specificity in the regulated endocytic membrane trafficking of G-protein-coupled receptors. Pharmacol Ther 89:139-147.
37. Wedegaertner PB (1998) Lipid modifications and membrane targeting of G alpha. Biol Signals Recept 7:125-135.
38. Wedegaertner PB, Bourne HR, and von Zastrow M (1996) Activation-induced subcellular redistribution of Gs alpha. Mol Biol Cell 7:1225-1233.
39. Weiss TS, Chamberlain CE, Takeda T, Lin P, Hahn KM, and Farquhar MG (2001) Gαi3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer of green fluorescent protein fusion proteins. Proc Natl Acad Sci USA 98:14961-14966.
40. Whistler JL, Tsao PI, and von Zastrow M (2001) A Phosphorylation-regulated brake mechanism controls the initial endocytosis of opioid receptors but is not required for post-endocytic sorting to lysosomes. J Biol Chem 276:34331-34388.
41. αs: dissociation of the activated G protein from plasma membrane. Mol Pharmacol 61:352-359.