B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice

Journal of Experimental Medicine

Volumn 197, Issue 9, 2003, Pages 1205-1211

  Brunner, Cornelia ^a   Marinkovic, Dragan ^a   Klein, Jörg ^b   Samardzic, Tatjana ^a   Nitschke, Lars ^b   Wirth, Thomas ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Affinity maturation; B cell differentiation; Germinal center reaction; Marginal zone; Transcription factor

Indexed keywords

PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; CROSS BREEDING; GERMINAL CENTER; LYMPHOPOIESIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTES; LYMPHOPOIESIS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANS-ACTIVATORS;

EID: 0038219633     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20022014     Document Type: Article

References (30)

1. Luo, Y., H. Fujii, T. Gerster, and R.G. Roeder. 1992. A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell. 71:231-241.
2. Pfisterer, P., S. Zwilling, J. Hess, and T. Wirth. 1995. Functional characterization of the murine homolog of the B-cell-specific coactivator BOB.1/OBF.1. J. Biol. Chem. 270: 29870-29880.
3. Gstaiger, M., L. Knoepfel, O. Georgiev, W. Schaffner, and C.M. Hovens. 1995. A B-cell coactivator of octamer-binding transcription factors. Nature. 373:360-362.
4. Luo, Y., and R.G. Roeder. 1995. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol. 15:4115-4124.
5. Qin, X.F., A. Reichlin, Y. Luo, R.G. Roeder, and M.C. Nussenzweig. 1998. OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development. EMBO J. 17:5066-5075.
6. Greiner, A., K. Müller, J. Hess, K. Pfeffer, K.H. Müller-Hermelink, and T. Wirth. 2000. BOB.1/OBF.1 expression is upregulated in normal germinal center B cells and germinal center derived B cell lymphomas. Am. J. Pathol. 156:501-507.
7. Boehm, J., Y. He, A. Greiner, L. Staudt, and T. Wirth. 2001. Regulation of BOB.1/OBF.1 stability by SIAH. EMBO J. 20:4153-4162.
8. Tiedt, R., B.A. Bartholdy, G. Matthias, J.W. Newell, and P. Matthias. 2001. The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1. EMBO J. 20:4143-4152.
9. Zwilling, S., A. Dieckmann, P. Pfisterer, P. Angel, and T. Wirth. 1997. Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science. 277:221-225.
10. Yu, X., L. Wang, Y. Luo, and R.G. Roeder. 2001. Identification and characterization of a novel OCA-B isoform. Implications for a role in B cell signaling pathways. Immunity. 14:157-167.
11. Schubart, D.B., A. Rolink, M.H. Kosco-Vilbois, F. Botteri, and P. Matthias. 1996. B-cell-specific coactivator OBF-1/ OCA-B/Bob1 required for immune response and germinal centre formation. Nature. 383:538-542.
12. Kim, U., F.-F. Qin, S. Gong, S. Stevens, Y. Luo, M. Nussenzweig, and R.G. Roeder. 1996. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature. 383: 542-547.
13. Nielsen, P.J., O. Georgiev, B. Lorenz, and W. Schaffner. 1996. B lymphocytes are impaired in mice lacking the transcriptional co-activator Bobl/OCA-B/OBF1. Eur. J. Immunol. 26:3214-3218.
14. Schubart, K., S. Massa, D. Schubart, L.M. Corcoran, A.G. Rolink, and P. Matthias. 2001. B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1. Nat. Immunol. 2:69-74.
15. Hess, J., P.J. Nielsen, K.D. Fischer, H. Bujard, and T. Wirth. 2001. The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development. Mol. Cell. Biol. 21:1531-1539.
16. Samardzic, T., D. Marinkovic, P.J. Nielsen, L. Nitschke, and T. Wirth. 2002. BOB.1/OBF.1 deficiency affects marginalzone B-cell compartment. Mol. Cell. Biol. 22:8320-8331.
17. Michaelidis, T.M., M. Sendtner, J.D. Cooper, M.S. Airaksinen, B. Holtmann, M. Meyer, and H. Thoenen. 1996. Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron. 17:75-89.
18. Samardzic, T., J. Gerlach, K. Muller, D. Marinkovic, J. Hess, L. Nitschke, and T. Wirth. 2002. CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Eur. J. Immunol. 32:2481-2489.
19. Samardzic, T., D. Marinkovic, C.P. Danzer, J. Gerlach, L. Nitschke, and T. Wirth. 2002. Reduction of marginal zone B cells in CD22-deficient mice. Eur. J. Immunol. 32:561-567.
20. Rolink, A., A. Kudo, H. Karasuyama, Y. Kikuchi, and F. Melchers. 1991. Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 10:327-336.
21. Strasser, A., S. Whittingham, D.L. Vaux, M.L. Bath, J.M. Adams, S. Cory, and A.W. Harris. 1991. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA. 88: 8661-8665.
22. Roes, J., and K. Rajewsky. 1993. Immunoglobulin D (IgD)- deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J. Exp. Med. 177: 45-55.
23. Niiro, H., and E.A. Clark. 2002. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2:945-956.
24. Li, Y.S., K. Hayakawa, and R.R. Hardy. 1993. The regulated expression of B lineage-associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951-960.
25. Hockenbery, D.M., M. Zutter, W. Hickey, M. Nahm, and S.J. Korsmeyer. 1991. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA. 88:6961-6965.
26. Martinez-Valdez, H., C. Guret, O. de Bouteiller, I. Fugier, J. Banchereau, and Y.J. Liu. 1996. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J. Exp. Med. 183: 971-977.
27. Martin, F., and J.F. Kearney. 2000. B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory". Immunol. Rev. 175:70-79.
28. Martin, F., and J.F. Kearney. 1999. CD21high IgMhigh splenic B cells enriched in the marginal zone: distinct phenotypes and functions. Curr. Top. Microbiol. Immunol. 246:45-50.
29. Cariappa, A., H.C. Liou, B.H. Horwitz, and S. Pillai. 2000. Nuclear factor KB is required for the development of marginal zone B lymphocytes. J. Exp. Med. 192:1175-1182.
30. Lu, T.T., and J.G. Cyster. 2002. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science. 297:409-412.