Early endotoxin exposure and atopy development in infants: Results of a birth cohort study

Clinical and Experimental Allergy

Volumn 33, Issue 6, 2003, Pages 770-776

  Bolte, G ^a,b   Bischof, W ^c   Borte, M ^d   Lehmann, I ^e   Wichmann, H E ^b   Heinrich, Joachim ^b  

^a UNIVERSITY OF ULM   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

Author keywords

Allergy; Asthma; Hygiene hypothesis

Indexed keywords

ENDOTOXIN; IMMUNOGLOBULIN E;

ALLERGIC DISEASE; ARTICLE; ATOPIC DERMATITIS; ATOPY; COHORT ANALYSIS; CONTROLLED STUDY; DUST EXPOSURE; EXPOSURE; FEMALE; FOOD ALLERGY; HIGH RISK POPULATION; HUMAN; HUMAN EXPERIMENT; IMMUNOGLOBULIN BLOOD LEVEL; INCIDENCE; INFANT; INHALATION; LOGISTIC REGRESSION ANALYSIS; MALE; MEASUREMENT; MEDICAL ASSESSMENT; PRIORITY JOURNAL; QUESTIONNAIRE; RISK FACTOR; SENSITIZATION; SYMPTOM; WHEEZING;

BEDDING AND LINENS; CHI-SQUARE DISTRIBUTION; DERMATITIS, ATOPIC; ENDOTOXINS; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; MULTIVARIATE ANALYSIS; PARENTS; PROSPECTIVE STUDIES; RESPIRATORY SOUNDS;

EID: 0038209297     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01665.x     Document Type: Article

References (35)

1. Riedler J, Braun-Fahrlander C, Eder W et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358:1129-33.
2. Von Mutius E, Braun-Fahrlander C, Schierl R et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000; 30:1230-4.
3. Nafstad P, Magnus P, Gaarder PI, Jaakkola JJ. Exposure to pets and atopy-related diseases in the first 4 years of life. Allergy 2001; 56:307-12.
4. Hesselmar B, Aberg N, Aberg B, Eriksson B, Bjorksten B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999; 29:611-7.
5. Heinrich J, Gehring U, Douwes J et al. Pets and vermin are associated with high endotoxin levels in house dust. Clin Exp Allergy 2001; 31:1839-45.
6. Liu AH. Endotoxin exposure in allergy and asthma: Reconciling a paradox. J Allergy Clin Immunol 2002; 109:379-92.
7. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001; 163:322-8.
8. Rizzo MC, Naspitz CK, Fernandez-Caldas E, Lockey RF, Mimica I, Sole D. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol 1997; 8:121-6.
9. Gereda JE, Leung DY, Thatayatikom A et al. Relation between house-dust endotoxin exposure, type 1 T cell development, and allergen sensitization in infants at high risk of asthma. Lancet 2000; 355:1680-3.
10. Litonjua AA, Milton DK, Celedon JC, Ryan L, Weiss ST, Gold DR. A longitudinal analysis of wheezing in young children. The independent effects of early life exposure to house dust endotoxin, allergens, and pets. J Allergy Clin Immunol 2002; 110:736-42.
11. Braun-Fahrländer C, Riedler J, Herz U et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347:869-77.
12. Gehring U, Bischof W, Fahlbusch B et al. House dust endotoxin and allergic sensitization in children. Am J Respir Crit Care Med 2002; 166:939-44.
13. Vogelzang PFJ, van der Gulden JWJ, Folgering H et al. Endotoxin exposure as a major determinant of lung function decline in pig farmers. Am J Respir Crit Care Med 1998; 157:15-8.
14. Christiani DC, Wang XR, Pan LD et al. Longitudinal changes in pulmonary function and respiratory symptoms in cotton textile workers. A 15-year follow-up study. Am J Respir Crit Care Med 2001; 163:847-53.
15. Baldini M, Lohmann IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20:976-83.
16. Lapa e Silva JR, Possebon da Silva MD, Lefort J, Vargaftig BB. Endotoxins, asthma, and allergic immune responses. Toxicology 2000; 152:31-5.
17. Gehring U, Bolte G, Borte M et al. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. J Allergy Clin Immunol 2001; 108:847-54 (Correction in J Allergy Clin Immunol 2002; 109:648).
18. Fahlbusch B, Heinrich J, Gross I, Jager L, Richter K, Wichmann HE. Allergens in house-dust samples in Germany: results of an East-West comparison. Allergy 1999; 54:1215-22.
19. Michel O, Nagy AM, Schroeven M et al. Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med 1997; 156:1157-64.
20. Nightingale JA, Rogers DF, Hart LA, Kharitonov SA, Chung KF, Barnes PJ. Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects. Thorax 1998; 53:563-71.
21. Michel O, Ginanni R, Le Bon B, Content J, Duchateau J, Sergysels R. Inflammatory response to acute inhalation of endotoxin in asthmatic patients. Am Rev Respir Dis 1992; 146:352-7.
22. Michel O, Kips J, Duchateau J et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154:1641-6.
23. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999; 354 (Suppl. II):12-5.
24. Eldridge MW, Peden DB. Allergen provocation augments endotoxin-induced nasal inflammation in subjects with atopic asthma. J Allergy Clin Immunol 2000; 105:475-81.
25. Dubin W, Martin TR, Swoveland P et al. Asthma and endotoxin, lipopolysaccharide-binding protein and soluble CD14 in bronchoalveolar compartment. Am J Physiol 1996; 270:L736-44.
26. Tulic MK, Wale JL, Holt PG, Sly PD. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol 2000; 22:604-12.
27. Nelde A, Teufel M, Hahn C et al. The impact of the route and frequency of antigen exposure on the IgE response in allergy. Int Arch Allergy Immunol 2001; 124:461-9.
28. Holt PG, Sly PD, Bjorksten B. Atopic versus infectious diseases in childhood, a question of balance? Pediatr Allergy Immunol 1997; 8:53-8.
29. Wan GH, Li CS, Lin RH. Airborne endotoxin exposure and the development of airway antigen-specific allergic responses. Clin Exp Allergy 2000; 30:426-32.
30. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-reduced airway hyper-reactivity but cause severe airway inflammation. J Clin Invest 1999; 103:175-83.
31. Bolte G, Krauss-Etschmann S, Konstantopoulos N et al. Different effects of endotoxin versus mite and cat allergen exposure on T cell differentiation in infants. J Allergy Clin Immunol 2002; 110:634-40.
32. Martinez FD. Development of wheezing disorders and asthma in preschool children. Pediatrics 2002; 109:362-7.
33. Tariq SM, Matthews SM, Hakim EA, Stevens M, Arshad SH, Hide DW. The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. J Allergy Clin Immunol 1998; 101:587-93.
34. Holt PG, Macaubas C, Prescott SL, Sly PD. Primary sensitization to inhalant allergens. Am J Respir Crit Care Med 2000; 162:S91-4.
35. Lehmann I, Thoelke A, Weiss M et al. T cell reactivity in neonates from an East and a West German city: results of the LISA study. Allergy 2002; 57:129-36.