Primary sensitization to inhalant allergens

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 3 II, 2000, Pages

  Holt, Patrick G ^a   Macaubas, Claudia ^a   Prescott, Susan L ^a   Sly, Peter D ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9;

ATOPY; CYTOKINE PRODUCTION; DERMATOPHAGOIDES PTERONYSSINUS; GENETIC RISK; HELPER CELL; HUMAN; IMMUNOLOGICAL MEMORY; INFANCY; INHALATION; PRIORITY JOURNAL; REVIEW; SENSITIZATION; T LYMPHOCYTE; VIRUS INFECTION;

EID: 0033830593     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.supplement_2.ras-7     Document Type: Review

References (18)

1. Transplacental priming of the human immune system to environmental allergens: Universal skewing of initial T cell responses towards the Th2 cytokine profile
2. Raised serum IgE associated with reduced responsiveness to DPT vaccination during infancy
3. T cell 'priming' against environnmental allergens in human neonates: Sequential deletion of food antigen specificities during infancy with concomitant expansion of responses to ubiquitous inhalant allergens
4. Inhalant allergen-specific T cell reactivity is detectable in close to 100% of atopic and normal individuals: Covert responses are unmasked by serum-free medium
5. Th2-polarised immunological memory to inhalant allergens in atopics is established during infancy and early childhood
6. Development of long term tolerance versus sensitization to environmental allergens during the perinatal period
7. Genetic 'risk' for atopy is associated with delayed postnatal maturation of T cell competence
8. Inverse association between tuberculin responses and atopic disorder
9. Development of allergen-specific T-cell memory in atopic and normal children
10. + T helper cell subsets in patients with atopic diseases
11. A topic versus infectious diseases in childhood: A question of balance?
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13. Hay fever, hygiene, and household size
14. Association of non-wheezing lower respiratory tract illnesses in early life with persistently diminished serum IgE levels
15. Role of viral infections in the inception of asthma and allergies during childhood: Could they be protective?
16. Environmental factors and primary T cell sensitization to inhalant allergens in infancy: Reappraisal of the role of infections and air pollutions
17. Intestinal microflora of Estonian and Swedish infants
18. A polymorphism in the 5'-flanking region of the CD14 gene is associated with circulating soluble CD14 levels with total serum IgE