Muscle creatine uptake and creatine transporter expression in response to creatine supplementation and depletion

Journal of Applied Physiology

Volumn 94, Issue 6, 2003, Pages 2173-2180

  Brault, Jeffrey J ^a   Abraham, Kirk A ^a   Terjung, Ronald L ^a,b  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Muscle fiber types; Phosphocreatine; guanidinoproprionic acid

Indexed keywords

CARRIER PROTEIN; CREATINE; CREATINE TRANSPORTER; GUANIDINOPROPIONIC ACID; MUSCLE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIET SUPPLEMENTATION; GASTROCNEMIUS MUSCLE; LIMB PERFUSION; MALE; MUSCLE CELL; MUSCLE LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; WESTERN BLOTTING;

EID: 0038178229     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01171.2002     Document Type: Article

References (45)

1. Armstrong RB and Phelps RO. Muscle fiber type composition of the rat hindlimb. Am J Anat 171: 259-272, 1984.
2. Baldwin KM, Klinkerfuss GH, Terjung RL, Mole PA, and Holloszy JO. Respiratory capacity of white, red, and intermediate muscle: adaptative response to exercise. Am J Physiol 222: 373-378, 1972.
3. Banos G, Daniel PM, Moorhouse SR, and Pratt OE. The movement of amino acids between blood and skeletal muscle in the rat. J Physiol 235: 459-475, 1973.
4. Bloch K, Schoenheimer R, and Rittenberg D. Rate of formation and disappearance of body creatine in normal animals. J Biochem 8: 155-166, 1941.
5. Boehm E, Chan S, Monfared M, Wallimann T, Clarke K, and Neubauer S. Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. Am J Physiol Endocrinol Metab 284: E399-E406, 2003.
6. Brannon TA, Adams GR, Conniff CL, and Baldwin KM. Effects of creatine loading and training on running performance and biochemical properties of rat skeletal muscle. Med Sci Sports Exerc 29: 489-495, 1997.
7. Brault JJ and Terjung RL. Creatine uptake and creatine transporter expression among rat skeletal muscle fiber types. Am J Physiol Cell Physiol. In Press.
8. Casey A, Constantin-Teodosiu D, Howell S, Hultman E, and Greenhaff PL. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol Endocrinol Metab 271: E31-E37, 1996.
9. Chen SC, Brown PR, and Rosie DM. Extraction procedures for use prior to HPLC nucleotide analysis using microparticle chemically bonded packings. J Chromatogr Sci 15: 218-221, 1977.
10. Connett RJ. Analysis of metabolic control: new insights using scaled creatine kinase model. Am J Physiol Regul Integr Comp Physiol 254: R949-R959, 1988.
11. Crim MC, Calloway DH, and Margen S. Creatine metabolism in men: creatine pool size and turnover in relation to creatine intake. J Nutr 106: 371-381, 1976.
12. Dodd JR, Zheng T, and Christie DL. Creatine accumulation and exchange by HEK293 cells stably expressing high levels of a creatine transporter. Biochim Biophys Acta 1472: 128-136, 1999.
13. Fitch CD, Jellinek M, and Mueller EJ. Experimental depletion of creatine and phosphocreatine from skeletal muscle. J Biol Chem 249: 1060-1063, 1974.
14. Fitch CD, Shields RP, Payne WF, and Dacus JM. Creatine metabolism in skeletal muscle. 3. Specificity of the creatine entry process. J Biol Chem 243: 2024-2027, 1968.
15. Goodyear LJ and Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med 49: 235-261, 1998.
16. Gorski J, Hood DA, and Terjung RL. Blood flow distribution in tissues of perfused rat hindlimb preparations. Am J Physiol Endocrinol Metab 250: E441-E448, 1986.
17. Greenhaff PL, Bodin K, Soderlund K, and Hultman E. Effect of oral creatine supple-mentation on skeletal muscle phosphocreatine resynthesis. Am J Physiol Endocrinol Metab 266: E725-E730, 1994.
18. Guerrero-Ontiveros ML and Wallimann T. Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: down-regulation of the expression of creatine transporter isoforms in skeletal muscle. Mol Cell Biochem 184: 427-437, 1998.
19. Harris RC, Soderlund K, and Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond) 83: 367-374, 1992.
20. Hood DA and Terjung RL. Leucine metabolism in perfused rat skeletal muscle during contractions. Am J Physiol Endocrinol Metab 253: E636-E647, 1987.
21. Horn M, Frantz S, Remkes H, Laser A, Urban B, Mettenleiter A, Schnackerz K, and Neubauer S. Effect of chronic dietary creatine feeding on cardiac energy metabolism and on creatine content in heart, skeletal muscle, brain, liver and kidney. J Mol Cell Cardiol 30: 277-284, 1998.
22. Hultman E, Soderlund K, Timmons JA, Cederblad G, and Greenhaff PL. Muscle creatine loading in men. J Appl Physiol 81: 232-237, 1996.
23. Ipsiroglu OS, Stromberger C, Ilas J, Hoger H, Muhl A, and Stockler-Ipsiroglu S. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci 69: 1805-1815, 2001.
24. Loike JD, Zalutsky DL, Kaback E, Miranda AF, and Silverstein SC. Extracellular creatine regulates creatine transport in rat and human muscle cells. Proc Natl Acad Sci USA 85: 807-811, 1988.
25. Mackie BG and Terjung RL. Blood flow to different skeletal muscle fiber types during contraction. Am J Physiol Heart Circ Physiol 245: H265-H275, 1983.
26. McMillen J, Donovan CM, Messer JI, and Willis WT. Energetic driving forces are maintained in resting rat skeletal muscle after dietary creatine supplementation. J Appl Physiol 90: 62-66, 2001.
27. Murphy R, McConell G, Cameron-Smith D, Watt K, Ackland L, Walzel B, Wallimann T, and Snow R. Creatine transporter protein content, localization, and gene expression in rat skeletal muscle. Am J Physiol Cell Physiol 280: C415-C422, 2001.
28. Nash SR, Giros B, Kingsmore SF, Rochelle JM, Suter ST, Gregor P, Seldin MF, and Caron MG. Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Receptors Channels 2: 165-174, 1994.
29. +-creatine cotransporter in failing human myocardium and in experimental heart failure. Circulation 100: 1847-1850, 1999.
30. Odoom JE, Kemp GJ, and Radda GK. The regulation of total creatine content in a myoblast cell line. Mol Cell Biochem 158: 179-188, 1996.
31. Op't Eijnde B, Richter EA, Henquin JC, Kiens B, and Hespel P. Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle. Acta Physiol Scand 171: 169-176, 2001.
32. Rooney K, Bryson J, Phuyal J, Denyer G, Caterson I, and Thompson C. Creatine supplementation alters insulin secretion and glucose homeostasis in vivo. Metabolism 51: 518-522, 2002.
33. Rowley GL, Greenleaf AL, and Kenyon GL. On the specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine. J Am Chem Soc 93: 5542-5551, 1971.
34. Saltarelli MD, Bauman AL, Moore KR, Bradley CC, and Blakely RD. Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Dev Neurosci 18: 524-534, 1996.
35. Schedel JM, Tanaka H, Kiyonaga A, Shindo M, and Schutz Y. Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations. Life Sci 65: 2463-2470, 1999.
36. Tarnopolsky MA and Parise G. Direct measurement of high-energy phosphate compounds in patients with neuromuscular disease. Muscle Nerve 22: 1228-1233, 1999.
37. Tarnopolsky MA, Parshad A, Walzel B, Schlattner U, and Wallimann T. Creatine transporter and mitochondrial creatine kinase protein content in myopathies. Muscle Nerve 24: 682-688, 2001.
38. Tullson PC, Rundell KW, Sabina RL, and Terjung RL. Creatine analogue β-guanidinopropionic acid alters skeletal muscle AMP deaminase activity. Am J Physiol Cell Physiol 270: C76-C85, 1996.
39. Tullson PC, Whitlock DM, and Terjung RL. Adenine nucleotide degradation in slow-twitch red muscle. Am J Physiol Cell Physiol 258: C258-C265, 1990.
40. Walzel B, Speer O, Boehm E, Kristiansen S, Chan S, Clarke K, Magyar JP, Richter EA, and Wallimann T. New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle. Am J Physiol Endocrinol Metab 283: E390-E401, 2002.
41. Walzel B, Speer O, Zanolla E, Eriksson O, Bernardi P, and Wallimann T. Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics. J Biol Chem 277: 37503-37511, 2002.
42. Wang WY, Jobst MA, Bell B, Zhao CR, Shang LH, and Jacobs DO. Cr supplementation decreases tyrosine phosphorylation of the CreaT in skeletal muscle during sepsis. Am J Physiol Endocrinol Metab 282: E1046-E1054, 2002.
43. Willott CA, Young ME, Leighton B, Kemp GJ, Boehm EA, Radda GK, and Clarke K. Creatine uptake in isolated soleus muscle: kinetics and dependence on sodium, but not on insulin. Acta Physiol Scand 166: 99-104, 1999.
44. Wiseman RW, Moerland TS, Chase PB, Stuppard R, and Kushmerick MJ. High-performance liquid chromatographic assays for free and phosphorylated derivatives of the creatine analogues β-guanidopropionic acid and 1-carboxy-methyl-2-iminoimidazolidine (cyclocreatine). Anal Biochem 204: 383-389, 1992.
45. Zhao CR, Shang LH, Wang WY, and Jacobs DO. Myocellular creatine and creatine transporter serine phosphorylation after starvation. J Surg Res 105: 10-16, 2002.