Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man

Xenobiotica

Volumn 33, Issue 5, 2003, Pages 541-560

  Webster, R ^a   Cole, S ^a   Gedge, J ^a   Roffey, S ^a   Walker, D ^a   Wild, W ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

QUINOXALINE DERIVATIVE; UK 240455; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG URINE LEVEL; HEPATOBILIARY SYSTEM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; KIDNEY CLEARANCE; KIDNEY TUBULE EXCRETION; LIVER CLEARANCE; MALE; NONHUMAN; NORMAL HUMAN; PLASMA PROTEIN BINDING; RAT; SPECIES DIFFERENCE; STROKE; TISSUE DISTRIBUTION;

ADOLESCENT; ADULT; ANIMALS; BILE; BINDING SITES; BLOOD PROTEINS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CENTRAL NERVOUS SYSTEM; DOGS; GLYCINE; HUMANS; MALE; MIDDLE AGED; N-METHYLASPARTATE; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TISSUE DISTRIBUTION;

CANIS FAMILIARIS;

EID: 0038171269     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/0049825031000085988     Document Type: Article

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