Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk+/- transgenic mice

Mutagenesis

Volumn 18, Issue 4, 2003, Pages 365-370

  Dobrovolsky, Vasily N ^a   McKinzie, Page B ^a   Shaddock, Joseph G ^a   Mittelstaedt, Roberta A ^a   Heflich, Robert H ^a   Parsons, Barbara L ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DNA; DNA POLYMERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; THYMIDINE KINASE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BONE MARROW; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; ENZYME DEFICIENCY; ERYTHROCYTE; FEMALE; GENE INSERTION; GENE MUTATION; GENOTYPE; HETEROZYGOSITY LOSS; LYMPHOCYTE CLONE; MALE; MICRONUCLEUS; MISMATCH REPAIR; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SPLEEN LYMPHOCYTE; SPONTANEOUS MUTATION; T LYMPHOCYTE; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LYMPHOCYTES; MICE; MICE, TRANSGENIC; MUTATION; THYMIDINE KINASE;

ANIMALIA; INSERTION SEQUENCES; MUS MUSCULUS;

EID: 0038156155     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/geg007     Document Type: Article

References (28)

1. Alani,E., Reenan,R.A. and Kolodner,R.D. (1994) Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae. Genetics, 137, 19-39.
2. Andrew,S.E., Xu,X.S., Baross-Francis,A., Narayanan,L., Milhausen,K., Liskay,R.M., Jirik,F.R. and Glazer,P.M. (2000) Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis, 21, 1291-1295.
3. Baker,S.M., Bronner,C.E., Zhang,L., Plug,A.W., Robatzek,M., Warren,G., Elliott,E.A., Yu,J., Ashley,T. and Arnheim,N. (1995) Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell, 82, 309-319.
4. Baker,S.M., Plug,A.W., Prolla,T.A. et al. (1996) Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nature Genet., 13, 336-342.
5. -/- murine small intestinal epithelial cells. Oncogene, 20, 619-625.
6. Borts,R.H., Chambers,S.R. and Abdullah,M.F. (2000) The many faces of mismatch repair in meiosis. Mutat. Res., 451, 129-150.
7. Dobrovolsky,V.N., Chen,T. and Heflich,R.H. (1999) Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes. Environ. Mol. Mutagen., 34, 30-38.
8. +/- mice: automated scoring of lymphocyte clones using a fluorescent viability indicator. Environ. Mol. Mutagen., 36, 283-291.
9. Dobrovolsky,V.N., Bucci,T., Heflich,R.H., Desjardins,J. and Richardson,F.C. (2003) Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease. Mol. Genet. Metab., 78, 1-10.
10. Guarne,A., Junop,M.S. and Yang,W. (2001) Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase. EMBO J., 20, 5521-5531.
11. Harfe,B.D. and Jinks-Robertson,S. (2000) DNA mismatch repair and genetic instability. Annu. Rev. Genet., 34, 359-399.
12. Hunter,N., Chambers,S.R., Louis,E.J. and Borts,R.H. (1996) The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid. EMBO J., 15, 1726-1733.
13. Inbar,O., Liefshitz,B., Bitan,G. and Kupiec,M. (2000) The relationship between homology length and crossing over during the repair of a broken chromosome. J. Biol. Chem., 275, 30833-30838.
14. Jones,I.M., Burkhart-Schultz,K. and Carrano,A.V. (1985) A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes. Mutat. Res., 147, 97-105.
15. Meng,Q., Skopek,T.R., Walker,D.M., Hurley-Leslie,S., Chen,T., Zimmer,D.M. and Walker,V.E. (1998) Culture and propagation of Hprt mutant T-lymphocytes isolated from mouse spleen. Environ. Mol. Mutagen., 32, 236-243.
16. Narayanan,L., Fritzell,J.A., Baker,S.M., Liskay,R.M. and Glazer,P.M. (1997) Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proc. Natl Acad. Sci. USA, 94, 3122-3127.
17. Prolla,T.A., Baker,S.M., Harris,A.C. et al. (1998) Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nature Genet., 18, 276-279.
18. Qin,X., Liu,L. and Gerson,S.L. (1999) Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT. Oncogene, 18, 4394-4400.
19. Qin,X., Shibata,D. and Gerson,S.L. (2000) Heterozygous DNA mismatch repair gene PMS2-knockout mice are susceptible to intestinal tumor induction with N-methyl-N-nitrosourea. Carcinogenesis, 21, 833-838.
20. Sancar,A. and Hearst,J.E. (1993) Molecular matchmakers. Science, 259, 1415-1420.
21. Schuettengruber,B., Doetzlhofer,A., Kroboth,K., Wintersberger,E. and Seiser,C. (2003) Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification. J. Biol. Chem., 278, 1784-1793.
22. -/ mice. Oncogene, 21, 2840-2845.
23. Stambrook,P.J., Shao,C., Stockelman,M., Boivin,G., Engle,S.J. and Tischfield,J.A. (1996) APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity. Environ. Mol. Mutagen., 28, 471-482.
24. Tinwell,H. and Ashby,J. (1989) Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays-including a triple dose study. Mutagenesis, 4, 476-481.
25. Wijnhoven,S.W., Van Sloun,P.P., Kool,H.J., Weeda,G., Slater,R., Lohman,P.H., van Zeeland,A.A. and Vrieling,H. (1998) Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse. Proc. Natl Acad. Sci. USA, 95, 13759-13764.
26. Wu,J., Gu,L., Wang,H., Geacintov,N.E. and Li,G.M. (1999) Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis. Mol. Cell. Biol., 19, 8292-8301.
27. Yao,X., Buermeyer,A.B., Narayanan,L., Tran,D., Baker,S.M., Prolla,T.A., Glazer,P.M., Liskay,R.M. and Arnheim,N. (1999) Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proc. Natl Acad. Sci. USA, 96, 6850-6855.
28. Zeng,M., Narayanan,L., Xu,X.S., Prolla,T.A., Liskay,R.M. and Glazer,P.M. (2000) Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Res., 60, 4889-4893.